1. MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
- Author
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Leonardi, R, Matthews, JB, Caltabiano, R, Greco, M, Lombardo, C, Loreto, C, Santarelli, A, and Lo Muzio, L
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ORAL surgery , *CHI-squared test , *COMPUTER software , *ENZYMES , *FISHER exact test , *IMMUNOHISTOCHEMISTRY , *DATA analysis , *ODONTOGENIC cysts , *EQUIPMENT & supplies , *SEVERITY of illness index , *CLASSIFICATION , *THERAPEUTICS ,DISEASE relapse prevention - Abstract
Oral Diseases (2010) 16, 795-800 Objective: To investigate the matrix metalloproteinase (MMP)-13 expression in associated and non-nevoid basal cell carcinoma syndrome (NBCCS) Odontogenic Keratocysts (OCKs) in order to contribute to a better understanding of the differences in the growth pattern between them. Materials and methods: Thirty-nine paraffin-embedded blocks of OCKs, 26 sporadic OCKs and 11 NBCCS-associated KCOTs were studied by immunohistochemistry to evaluate MMP-13 expression both in epithelial and stromal layers. A semi-quantitative scale was used to evaluate immunostaining. Obtained data were compared between the two groups, using Fischer's exact test and the chi-square test. Results: Only 13 of 26 sporadic OCKs showed a positive immunostaining, whilst 11 KCOTs resulted in positive labelling for MMP-13 expression. Moreover, syndromic cysts displayed a more intense and diffuse MMP-13 labelling of the stromal tissue. Instead, in non-syndromic forms, the staining pattern of MMP-13 in stromal tissue was completely absent. Fisher's exact test showed a statistically significant greater prevalence of KCOTs-immunolabelled cysts with respect to sporadic OCKs. Conclusions: Results from this study point out that the biological behaviour of these cysts could be related not only to the epithelial layer but also to stromal tissue in that... MMP-13 overexpression in stromal tissue of NBCCS-associated KCOTs could clarify the higher aggressiveness of these cysts. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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