26 results on '"Esposito, I"'
Search Results
2. PCV43 - Costs And Outcomes Of Patients Admitted For A Cardiovascular Ischemic Disease In A Large Community Setting Of 2,989,512 Subjects Of The Italian National Health Service (Nhs).
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Maggioni, A.P., Cinconze, E., Rossi, E., De Rosa, M., Esposito, I., and Martini, N.
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CARDIOVASCULAR disease treatment , *HEALTH outcome assessment , *MEDICAL care costs , *NATIONAL health services , *PUBLIC health - Published
- 2015
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3. [The care pathway of patients with diffuse large B-cell lymphoma described through Italian administrative healthcare data.]
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Dondi L, Ronconi G, Dondi L, Calabria S, Dell'Anno I, Piccinni C, Addesi A, Esposito I, and Martini N
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- Humans, Italy, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adult, Rituximab administration & dosage, Kaplan-Meier Estimate, Hematopoietic Stem Cell Transplantation, Health Care Costs statistics & numerical data, Vincristine administration & dosage, Follow-Up Studies, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Doxorubicin administration & dosage, Prednisone administration & dosage, Prednisone therapeutic use, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse therapy, Lymphoma, Large B-Cell, Diffuse epidemiology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antineoplastic Combined Chemotherapy Protocols economics, Databases, Factual
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Introduction: The diffuse large B-cell lymphoma (Dlbcl) is the most common non-Hodgkin lymphoma and at highest incidence among the elderly. Despite the improved outcomes of patients treated with the first-line (1L) standard of care until the end of 2022, composed by rituximab and polychemotherapy (R-Chop), during the last 20 years, the rate of relapsed and refractory Dlbcl (rrDlbcl) remains elevated. This study has identified and analyzed patients newly diagnosed with Dlbcl and treated with 1L, from the perspective of the Italian National Health Service (Ssn)., Methods: From the administrative database of Fondazione Ricerca e Salute (ReS) including ~5.5 million inhabitants/year in Italy, adults with a new in-hospital Dlbcl diagnosis (index date) and treated with 1L in 2018, 2019, 2020 and 2021 were identified and characterized in terms of demographics and comorbidities during a period (from 4 to 8 years) preceding index date. From 1 to 4 years following index date (follow-up), overall survival (Kaplan-Meier curves), percentage distribution of patients by line of therapy including dispensation/administration of chemo-immunotherapy, hemopoietic stem cell transplantation (Hsct), and direct healthcare costs charge to the Ssn, were evaluated., Results: Overall, from the ReS database, 206 patients newly diagnosed with Dlbcl and treated with 1L from 2018 to 2021 in Italy (incidence from 0.9 to 1.7 x100,000 adult inhabitants) were identified. They were mainly older (median age 68 [56; 75] years), males (56%) and affected by ≥2 comorbidities (52%), mostly cardiometabolic. During 4 years of follow-up, 56% of cases in 2018 survived. During the first follow-up year: 73%, 80%, 100% and 35% of cases in 2018, 2019, 2020 and 2021, respectively, received a 2L; 42% and 64% of cases in 2018 and 2020, respectively, received a 3L. At least one Hsct was found as a 2L among cases in 2018, 2020 and 2021. On average, each patient newly diagnosed with Dlbcl and treated with 1L from 2018 to 2021 caused a total expenditure directly charged to the Ssn ranging from € 20,000 to € 30,000 during the first follow-up year (chemo-immunotherapy accounted for 40-53%), which reduced with time in favor of other drugs and Hsct., Conclusions: This analysis confirms the high rate of rrDlbcl and the high economic impact charged to the SSN to support first the chemo-immunotherapy, then the chronic care and the absence of standardized further lines of therapy for patients with rrDlbcl.
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- 2024
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4. Italian healthcare resource consumptions and direct costs of adults with atopic dermatitis before and after dupilumab treatment.
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Ronconi G, Dondi L, Calabria S, Dondi L, Pedrini A, Esposito I, Scattareggia M, Rogliani P, Trimarchi M, Costanzo A, Patruno C, Naldi L, and Martini N
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- Humans, Male, Female, Adult, Italy, Middle Aged, Health Care Costs statistics & numerical data, Hospitalization economics, Hospitalization statistics & numerical data, Comorbidity, Young Adult, Asthma drug therapy, Asthma economics, Health Resources economics, Health Resources statistics & numerical data, Dermatitis, Atopic drug therapy, Dermatitis, Atopic economics, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Monoclonal, Humanized economics
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Background: Atopic dermatitis (AD) is a heterogeneous disease, associated with comorbidities, and high healthcare consumptions and costs. This study assessed the burden before and after treatment with dupilumab in adults with severe AD from 2018 to 2020, from the perspective of the Italian National Health Service (SSN)., Methods: From Fondazione Ricerca e Salute's administrative healthcare database (~5 million inhabitants/year), adults treated with dupilumab from 09/01/2018 to 31/12/2020 (index date) and a five-year lookback were identified. Age, sex and comorbidities at baseline, concomitant drugs, overnight hospitalizations, outpatient specialist services and direct costs charged to the SSN one year before/after index date were assessed., Results: Of 337 adults treated with dupilumab (5.8x100,000 adult inhabitants/2019; 8.0x100,000/2020; 55% males; mean age 43±19), 68% (228/337) had ≥12-month follow-up available. Asthma was a common comorbidity (23% patients). Rates of patients treated with nearly all concomitant AD-related therapies reduced from 12 months before to 12 months after dupilumab treatment: antibacterials (from 59% to 50%), systemic corticosteroids (55% to 29%), antihistamines (54% to 38%) and cyclosporine (52% to 7%). A similar trend was observed among patients with asthma as comorbidity. Within 12 months before/after dupilumab, patients hospitalized halved from 14% to 7%, and patients receiving outpatient specialist care reduced from 72% to 65%. Annual mean direct total costs per patient treated with dupilumab charged to the SSN, net of dupilumab cost, were €1384 and €773, before and after dupilumab dispensation, respectively., Conclusions: Before dupilumab, observed patients had higher healthcare resource consumptions and direct SSN costs than after dupilumab.
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- 2024
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5. The Early Access and the Potential Cost Savings by the Compassionate Use of Onco-haematological Drugs: Results from the Italian Study Compass-O.
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Dell'Anno I, Dondi L, Esposito I, Mascolo A, Capuano A, de Marchi G, Cristinziano A, Tarantino D, Pani M, Masini C, Donati C, Rossin E, Serafini A, Bagaglini G, Bonanni G, Gregori T, Cavaliere A, Matocci R, D'Arpino A, Martini N, and Piccinni C
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- Humans, Italy, Retrospective Studies, Neoplasms drug therapy, Neoplasms economics, Compassionate Use Trials, Cost Savings, Antineoplastic Agents economics, Antineoplastic Agents therapeutic use
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Background: Compassionate drug use (CDU) provides early access to not yet authorised medicines and is funded by pharmaceutical companies. The observational retrospective study Compass-O monitored the CDU of onco-haematological drugs, managed by seven Italian units for cytotoxic drug preparations (Unità Farmaci Antiblastici [UFA]), between 1 January, 2016 and 31 December, 2021., Objective: We aimed to evaluate the CDU of onco-haematological drugs managed by seven Italian UFA, between 2016 and 2021., Methods: The seven UFA provided anonymised data concerning CDU approved in the study period. The early access and potential cost savings for the National Health System (Servizio Sanitario Nazionale [SSN]) were analysed for CDU concerning drug-therapeutic indication combinations with complete data and reimbursed by SSN up to December 2023 (date of study execution), according to the executive decision of the Italian Medicines Agency (Agenzia Italiana del Farmaco [AIFA]). Both analyses distinguished solid/liquid tumours and categorised the combinations as innovative (fully/conditionally) or non-innovative based on AIFA assessments., Results: Compass-O collected 783 CDU authorisations, with 572 (73.1%) analysable in terms of early access and cost savings. On average, early access amounted to 514 days and the total cost savings was €376,115,801. Compassionate drug use approvals involved mainly solid tumours (93.7% vs 6.3% for liquid tumours), and the combination of trastuzumab emtansine-breast cancer was the most dispensed (n = 73; early access = 426 days; potential cost savings: €610,388). Out of 572 CDU approvals, 200 (35%) were innovative drug-therapeutic indication combinations, with 598 days of early access and a total potential saving of €113,124,069., Conclusions: The study Compass-O showed a significant economic burden of CDU and a relevant need for early access, particularly for innovative drugs. However, there is currently no structured monitoring of CDU in Italy, suggesting the need for a national observatory, of which Compass-O can be the pilot phase., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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- 2024
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6. HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients.
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Andreani M, Mariotti F, Pira A, Locatelli F, Testa G, Battarra M, Caputi P, Scarabello A, Bellei B, Campli CD, Collina MC, Esposito I, Giampetruzzi AR, Didona B, Pitocco D, Simone C, and Zenzo GD
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- Humans, Italy, Female, Male, Aged, Diabetes Mellitus, Type 2 genetics, Diabetes Mellitus, Type 2 drug therapy, HLA-DQ beta-Chains genetics, Middle Aged, Gene Frequency, Aged, 80 and over, Pemphigoid, Bullous genetics, Pemphigoid, Bullous chemically induced, Genetic Predisposition to Disease, Alleles, Haplotypes
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Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2024
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7. Primary Sjögren's syndrome in Italy: Real-world evidence of a rare disease through administrative healthcare data.
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Cafaro G, Perricone C, Ronconi G, Calabria S, Dondi L, Dondi L, Pedrini A, Esposito I, Gerli R, Bartoloni E, and Martini N
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- Humans, Italy epidemiology, Female, Male, Middle Aged, Aged, Adult, Case-Control Studies, Health Care Costs statistics & numerical data, Prevalence, Databases, Factual, Aged, 80 and over, Sjogren's Syndrome epidemiology, Sjogren's Syndrome economics, Rare Diseases epidemiology, Rare Diseases economics, Hospitalization economics, Hospitalization statistics & numerical data
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Objectives: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with significant impact on morbidity, mortality, and quality of life. This study aimed to evaluate epidemiology, healthcare needs and related costs of pSS patients from the Italian National Health Service perspective., Methods: From the Fondazione Ricerca e Salute's database (∼5 million inhabitants/year), pSS prevalence in 2018 was calculated. Demographics, mean healthcare consumptions and direct costs at one year following index date (first in-hospital diagnosis/disease waiver claim) were analysed through an individual direct matched pair case-control analysis (age, sex, residency)., Results: In Italy, 3.8/10,000 inhabitants were identified as affected by pSS (1,746 case: 1,746 controls) in 2018. In the year following index date, 53.7% of cases and 42.7% of controls received ≥1 drug (p<0.001); mean per capita cost was €501 and €161, respectively (p<0.01). At least one hospitalization occurred to 7.8% of cases and 3.9% of controls (p<0.001) with mean per capita costs of €416 and €129, respectively (p = 0.46). At least one outpatient specialist service was performed in 49.8% of cases and 30.6% of controls (p<0.001); mean per capita costs were €200 and €75, respectively (p<0.01). Overall, mean annual costs were €1,171 per case and €372 per control (p < 0.01)., Conclusion: According to results of this population-based study, the prevalence of pSS in Italy appears to be consistent with the definition of rare disease. Patients with pSS have higher pharmacological, in-hospital and outpatient specialist care needs, leading to three-times higher overall cost for the INHS, compared to the general population., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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8. [A view of care pathways approved by Italian Regions, to face the challenge of the community-based healthcare: a quali-quantitative analysis of the Pdta Net database.]
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Dell'Anno I, Calabria S, Dondi L, Ronconi G, Dondi L, Addesi A, Pedrini A, Esposito I, Maggioni AP, Martini N, and Piccinni C
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- Humans, Italy, Delivery of Health Care, Chronic Disease, Critical Pathways, State Medicine
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Introduction: The adoption of a Care Pathway (CP) allows the healthcare management of patients suffering from high-epidemiological impact chronic diseases. The continuity of care of these patients is one of the main purposes of the community-based healthcare reform, foreseen in the 6th Mission of the National recovery and resilience plan. Fondazio-ne Ricerca e Salute (ReS) collects and analyses regional CPs approved in Italy, through the Pdta Net database., Methods: Fondazione ReS has retrieved all the CPs approved by Italian Regions and Autonomous provinces until 12/31/2021 within institutional websites, through specific keywords. The quali- and quantitative analysis of CPs was based on the approving Region, the publication year, the disease (distinguishing between high-epidemiological impact chronic diseases and rare conditions) and clinical area. Following the 5-year experience gained by Fondazione ReS in terms of CPs' aims and organization for the full realization of an evidence-based healthcare of chronic patients, all data collected until 12/31/2021 underwent an in-depth double-blinded quality control. This control was aimed to make the Pdta Net database as representative as possible of the existing documents closest to a real CP., Results: From 2005 to 2021, 729 regional CPs have been approved: 404 on high-impact chronic diseases and 220 on rare conditions. The CPs of chronic diseases, mostly edited by Piemonte (45 CPs), Campania (34) and Toscana (33) Regions, mainly concern on diabetes (19), chronic obstructive pulmonary disease (15), heart failure (13), stroke, multiple sclerosis and colorectal neoplasms (12 each one), breast cancer (11), dementia and chronic kidney disease (10 each one). Most of the CPs on rare diseases have been edited by Regions with an established Rare Disease Network, i.e., Lombardia (125 CPs), Lazio (74) and Toscana (40): neurology (61) and oncology (52) were the most represented clinical areas., Conclusions: The high number of CPs approved in Italy confirms an increasing interest of the healthcare institutions. The collected CPs show an extreme variety of titles, text structures and disease choices. Given the absence of an institutional observatory and of devotees of shared and harmonized CPs, annually Pdta Net makes available an updated and complete overview of these governance tools, which are essential for the upcoming changes of the Italian national health service.
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- 2023
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9. Renal function and cardiac adrenergic impairment in patients affected by heart failure.
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Marsico F, Paolillo S, Gargiulo P, Parisi V, Nappi C, Assante R, Dell'Aversana S, Esposito I, Renga F, Esposito L, Bardi L, Rengo G, Dellegrottaglie S, Marciano C, Leosco D, Cuocolo A, and Filardi PP
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- Aged, Female, Heart physiopathology, Heart Failure physiopathology, Humans, Italy, Kidney physiopathology, Kidney Diseases physiopathology, Male, Middle Aged, Statistics, Nonparametric, Adrenergic Agents metabolism, Heart Failure complications, Kidney Diseases etiology
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Although in heart failure (HF) there is a strict correlation between heart and kidney, no data are available on the potential relationship in HF between renal dysfunction (RD) and the impaired sympathetic innervation. Aim of the present study was to assess the relationship between RD and cardiac sympathetic innervation in HF patients with reduced ejection fraction. Two hundred and sixty-three patients with mild-to-severe HF underwent iodine-123 meta-iodobenzylguanidine myocardial scintigraphy to assess sympathetic innervation, evaluating early and late heart-to-mediastinum (H/M) ratios and washout rate. In all patients, glomerular filtration rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was assessed. A direct association was found between EPI-eGFR and late H/M (r = .215; P < .001). Dividing the population into moderate-to-severe eGFR reduction and normal-to-mildly reduced eGFR (cutoff ≤ 60 mL·min
-1 ·1.73 m-2 ), a statistically significant reduction of late H/M value was found in patients with RD compared to patients with preserved eGFR (P = .030). By multivariable linear regression analysis, eGFR resulted in the prediction of impaired late H/M in patients with RD (P = .005). Patients with RD and HF show more impaired cardiac sympathetic activity than HF patients with preserved renal function, and reduced eGFR is a predictor of reduced late H/M., (© 2019. American Society of Nuclear Cardiology.)- Published
- 2021
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10. Insights into real-world treatment of cluster headache through a large Italian database: prevalence, prescription patterns, and costs.
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Piccinni C, Cevoli S, Ronconi G, Dondi L, Calabria S, Pedrini A, Maggioni AP, Esposito I, Addesi A, Favoni V, Pierangeli G, Cortelli P, and Martini N
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- Adolescent, Adult, Aged, Cluster Headache economics, Cross-Sectional Studies, Databases, Factual, Drug Costs, Female, Humans, Italy, Lithium Carbonate administration & dosage, Lithium Carbonate economics, Longitudinal Studies, Male, Middle Aged, Oxygen administration & dosage, Oxygen economics, Prevalence, Sumatriptan administration & dosage, Sumatriptan economics, Verapamil administration & dosage, Verapamil economics, Young Adult, Cluster Headache drug therapy, Health Care Costs statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data
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Objective : This study aimed at estimating the treated cluster headache (CH) prevalence and describing prescription patterns and direct costs paid by the Italian National-Health-System. Methods : Through the ReS database (healthcare administrative data collection of a large sample of the Italian population), adults in treatment for CH (acute therapy with sumatriptan/subcutaneous or oxygen, associated with preventive therapy with verapamil or lithium) were selected. A cross-sectional analysis described the prevalence of CH-treated subjects repeated annually in 2013-2017. A longitudinal analysis of patients selected in 2013-2015 and followed for 2 years provided the prescription patterns. Results : The annual prevalence of CH-treated patients increased from 6.4×100,000 adults in 2013 to 6.7 in 2017. In 2013-2015, 570 patients (80.7% M; mean age 46) treated for CH were found. In 50.4%, the identifying CH treatment was sumatriptan/subcutaneous+verapamil. During follow-up, >1/3 changed the preventive drug and interruption was the most frequent modification, although acute treatments were still prescribed. The mean annual cost/patient ranged from €2,956 to €2,267; pharmaceuticals expenditure represented the 56.4% and 57.3%, respectively. Conclusions : This study showed an important unmet need among CH patients, carrying a high economic burden that should be considered in the evaluation of the impact of incoming therapies (e.g. Calcitonin-Gene-Related-Peptide antibodies).
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- 2021
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11. Real-world Prescription Pattern, Discontinuation and Costs of Ibrutinib-Naïve Patients with Chronic Lymphocytic Leukemia: An Italian Healthcare Administrative Database Analysis.
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Ronconi G, Dondi L, Calabria S, Piccinni C, Pedrini A, Esposito I, and Martini N
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- Adenine therapeutic use, Aged, Databases, Factual, Female, Humans, Italy, Leukemia, Lymphocytic, Chronic, B-Cell economics, Male, Medication Adherence, Middle Aged, Adenine analogs & derivatives, Drug Prescriptions statistics & numerical data, Health Care Costs, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Piperidines therapeutic use, Protein Kinase Inhibitors therapeutic use
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Background and Objective: In order to integrate the existing and inconsistent information from clinical trials and real-world practice on chronic lymphocytic leukemia (CLL) treated with ibrutinib, this analysis aimed to describe the prescription pattern of new users of ibrutinib affected by CLL, focusing on discontinuation, severe adverse events (AEs) and change of treatment, and to assess the integrated healthcare expenditure from the Italian National Health System (INHS) perspective., Methods: Starting from the ReS database, adults with at least a supply of ibrutinib (ATC code L01XE27) were selected from 01/01/2016 to 12/31/2017. Those without any ibrutinib supply in the year before the index prescription were considered new users. Out of them, only patients with at least a primary or secondary in-hospital diagnosis of CLL (ICD-9-CM code 204.1*) from 01/01/2013 to 12/31/2018 were further broken down according to the ibrutinib's line treatment (first line-FL; second or later line-SLL) and analysed. They were characterized by sex and age in the selection period. Mean annual consumption (defined daily doses [DDD]), treatment discontinuation, changes of therapy, interruptions and healthcare costs in charge of the INHS were assessed during two follow-up years., Results: Out of more than 5 million inhabitants of the ReS database, 69 new ibrutinib users and diagnosed with CLL in 2016 (incidence: 1.6 × 100,000) and 41 in 2017 (incidence: 0.9 × 100,000) were selected. Of these, 21 (19.1%) were FL ibrutinib users and 89 (80.9%) were SLL ones, mostly males and with mean ages (±SD) of 65 ± 14 and 70 ± 10, respectively. The mean annual consumption among FL users decreased from 222.2 DDD per patient treated to 216.0 DDD, while increased among SLL patients from 238.6 DDD to 260.1 DDD, in the first and second follow-up year, respectively. The discontinuation rate was about 40% in the first year, similarly among FL and SLL users. SLL patients discontinued more frequently (52.8% vs 20.0%) in the second year. Very few AEs were recorded. The 62.5% of FL and 55.6% of SLL users discontinuing ibrutinib in 1-year follow-up, while one SLL patient (5.3%) in the second year changed therapy. The 20.0% and 15.9% of all new users in first and second year interrupted ibrutinib. The total integrated cost of FL patients was €55,732 reducing by about €15,000, while it was €58,716 for SLL ones decreasing by €6,000, respectively, in the first and in the second year. Pharmaceuticals were the key cost driver (ibrutinib accounted for more than 77%)., Conclusions: This analysis on Italian administrative data provided results about prescription patterns of ibrutinib FL and SLL new users with CLL, focusing on discontinuation, treatment change and healthcare costs over 2-year follow-up, and contributed to improve the knowledge on this hard-to-treat disease.
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- 2021
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12. [Therapeutic drug plans: how many and which ones? Overview of a prescriptive and care appropriateness tool.]
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Piccinni C, Addesi A, Pedrini A, Esposito I, Rampazzo R, Mezzalira L, Trentin L, Font M, Trotta F, Pierantozzi A, Di Filippo A, Altamura G, Da Cas R, and Martini N
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- Humans, Italy, Clinical Protocols, Drug Prescriptions standards
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Therapeutic plans (TPs) were introduced in Italy in 2004 in order to ensure the continuity in the prescription of new drugs between specialist physicians and general practitioners (GPs). Over the years this prescription tool was updated several times: starting from a paper form without any template ("paper TP") to a template defined by AIFA to collect specific clinical information, up to a web-based form to collect all information into a database. Over time-critical issues concerning its usefulness have been raised, especially when AIFA established several extensions for TP validity to ensure the social distancing required by the covid-19 pandemic. Therefore, after several years from their establishment, pending adoption of necessary implementing of Ministerial Decree of 25th March 2020, a check of the actual impact of TPs is required, in order to plan their review. This study provide a detailed overview of all TPs active in Italy at the 11th May 2020. From Farmadati database, all drugs reimbursed by the National Health Service (class A drugs) and requiring TP were selected. The consumption of these drugs has been derived from OsMed Reports that make available data of medicines consumption and expenditure in the general population in Italy. The analysis showed that TP is required for the prescription of 935 medicinal products (9.6% of class-A drugs) and 147 different active substances (belonging to 34 different Therapeutic Groups and 66 subgroups). Out of these, 67 (46%) required a paper TP without any template, 72 (49%) a paper TP on AIFA template, and 8 (5%) a web-based TP. The Therapeutic Group with the largest number of active ingredients with TP were antidiabetics (19.7%), followed by immunomodulating and immunosuppressants (9.5%) and medications for asthma and COPD (6.8%). Consumption analysis of drugs with TP showed that this prescription tool covers 943,899,598 DDD per year, equal to 2,586,026 DDD/day. This means that TPs have a very high impact in terms of the prevalence of patients treated on the entire care process. Of all annual DDDs prescribed on TP, 46.8% concerned drugs with TP on template AIFA, 34.5% drugs with web-based TP, while the remaining 18.7% drugs with paper TP without a template. This analysis may provide the basis for an analytical case-by-case review of TP maintenance needs, trying to maximize the benefits of this tool and to reduce its possible adverse effects. This review could be helpful to ensure the appropriateness in the drug uses, to enhance the role of general medicine, and to simplify the pathways of millions of patients ensuring the continuity of their care.
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- 2021
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13. Real-world data on new users of atypical antipsychotics: characterisation, prescription patterns, healthcare costs and early cardio-metabolic occurrences from a large Italian database.
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Piccinni C, Dondi L, Ronconi G, Calabria S, Esposito I, Pedrini A, Maggioni AP, Barbui C, and Martini N
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- Adolescent, Adult, Aged, Aged, 80 and over, Antipsychotic Agents adverse effects, Cardiometabolic Risk Factors, Cardiovascular Diseases economics, Databases, Factual, Female, Humans, Italy epidemiology, Male, Metabolic Diseases economics, Middle Aged, Young Adult, Antipsychotic Agents administration & dosage, Cardiovascular Diseases epidemiology, Health Care Costs statistics & numerical data, Metabolic Diseases epidemiology, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Purpose: To describe new users of atypical antipsychotics (APs) in terms of sociodemographic characteristics, cardio-metabolic risk profile, prescription patterns, healthcare costs and cardio-metabolic events over the 24 months after treatment initiation., Methods: Atypical AP new users were selected from the ReS database and grouped into three: patients already affected by cardio-metabolic diseases (group A), patients without these clinical conditions but with predisposing conditions (group B) and patients without cardio-metabolic diseases and predisposing conditions (group C). Annual prescription patterns and healthcare costs were analysed. Subjects of groups B and C were matched with controls to compare the occurrences of cardio-metabolic events over 24 months., Results: Thirty-two thousand thirty-four new users of atypical APs were selected (median age 69). The 22.3% had cardio-metabolic diseases, 14.8% had predisposing conditions and 62.9% had none of these. The 99.3% received monotherapy. The mean annual cost per patient was €2785, and the median cost was €1108. After 24 months, a cardio-metabolic event occurred in 11.5% of group B vs. 8.7% of the controls (p < .01), and in 5.0% of group C vs. 2.1% of the controls (p < .01)., Conclusion: Patients treated with atypical AP were on average old and, in a non-negligible amount, with cardio-metabolic disease or predisposing conditions. New users of atypical APs showed a significantly higher likelihood to develop a cardio-metabolic event early after treatment initiation.
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- 2020
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14. Identification of cases and estimate of direct costs of unresectable and advanced cutaneous squamous cell carcinoma: real-world data from a large Italian database.
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Ronconi G, Piccinni C, Dondi L, Calabria S, Pedrini A, Esposito I, Ascierto PA, Naldi L, and Martini N
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- Databases, Factual, Humans, Italy epidemiology, Retrospective Studies, Carcinoma, Squamous Cell, Skin Neoplasms
- Published
- 2020
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15. Open triple therapy for chronic obstructive pulmonary disease: Patterns of prescription, exacerbations and healthcare costs from a large Italian claims database.
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Calabria S, Ronconi G, Dondi L, Piccinni C, Pedrini A, Esposito I, Pistelli R, and Martini N
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- Administration, Inhalation, Adrenal Cortex Hormones therapeutic use, Adrenergic beta-2 Receptor Agonists therapeutic use, Aged, Aged, 80 and over, Female, Humans, Italy, Male, Middle Aged, Muscarinic Antagonists therapeutic use, Spirometry, Bronchodilator Agents therapeutic use, Health Care Costs statistics & numerical data, Prescriptions statistics & numerical data, Pulmonary Disease, Chronic Obstructive drug therapy, Pulmonary Disease, Chronic Obstructive economics
- Abstract
Background: The combination of two long acting bronchodilators with an inhaled corticosteroid, known as Triple Therapy (TT), is a usual clinical practice for patients affected by chronic obstructive pulmonary disease (COPD). This analysis aimed to identify subjects with COPD treated with extemporaneous combination of ICS/LABA and LAMA (namely open TT) and to describe the pharmacological strategy, the spirometry use, the exacerbations occurrence and the costs, in the perspective of the Italian National Health System (NHS)., Methods: Through record linkage of administrative data (ReS database) of about 12 million inhabitants in 2014, a cohort of patients aged ≥45, without asthma and treated with open TT (index date) was selected. Specific drugs, oxygen supply and exacerbations were described in one year before the index date, while spirometry tests over two years before the index date. All these resources utilization, the persistence to the open TT, and integrated costs of the above healthcare services were analysed for 1-year follow-up., Results: In 2014, 10,352 patients (mean age 74 ± 9; males 66.0%) with COPD and treated with open TT were identified (prevalence 160.6 per 100,000 inhabitants aged ≥45). During the previous year, the 44.0% of this cohort was already treated with open TT, 7.0% did not received any drugs for obstructive airway diseases, 11.1% needed home oxygen therapy, and 28.7% experienced at least an exacerbation. In the follow-up year, the 37.5% of the cohort was found persistent to the open TT, 17.0% needed oxygen therapy, and the 30.9% underwent an exacerbation. Spirometry was performed on 45.7% of patients in the two previous years, while on 33.3% in the subsequent year. In the follow-up, on average, every patient of the cohort costed to the NHS €5,295: 48.2% for hospitalizations, 41.2% for drugs and 10.6% for outpatient services., Conclusions: This large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
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16. Anticancer drug prices and clinical outcomes: a cross-sectional study in Italy.
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Trotta F, Mayer F, Barone-Adesi F, Esposito I, Punreddy R, Da Cas R, Traversa G, Perrone F, Martini N, Gyawali B, and Addis A
- Subjects
- Case-Control Studies, Cost-Benefit Analysis, Cross-Sectional Studies, Disease-Free Survival, Humans, Italy, Negotiating, Neoplasms economics, Progression-Free Survival, Retrospective Studies, Antineoplastic Agents economics, Drug Costs statistics & numerical data, Neoplasms drug therapy
- Abstract
Objective: To investigate whether the prices of new anticancer drugs correlated with their relative benefit despite negotiation., Design: Retrospective cross-sectional study correlating new anticancer drugs prices with clinical outcomes., Setting: We did a retrospective cross-sectional study including all new anticancer drugs approved by the European Medicines Agency (EMA) (2010-2016) and reimbursed in Italy., Main Outcomes and Measures: Information on clinical outcomes-in terms of median overall survival (OS), median progression-free survival (PFS) and objective response rate (ORR)-was extracted from pivotal trials as reported in the European Public Assessment Reports available on the EMA website. Cost of a full course treatment was estimated on negotiated official and discounted prices. Regression coefficients β, their levels of significance p and the coefficients of determination R
2 were estimated adjusting by tumour type., Results: Overall, 30 new anticancer drugs (with 35 indications) were available for analysis. Where data on OS were available, we observed no correlation between the improvement in median OS (in weeks) and negotiated price (R2 =0.067, n=16 drugs for 17 indications). When the clinical outcomes were expressed as improvements in the median PFS or ORR, 25 drugs (29 indications) were available for the analysis, and again, there was no correlation with prices (R2 =0.004 and 0.006, respectively)., Conclusions and Relevance: Our results suggest that the prices of anticancer drugs in Italy do not reflect their therapeutic benefit. Drug price negotiations, which is mandatory by law in Italy, do not seem to ensure that prices correlate with clinical benefits provided by the cancer drugs. These results call for further efforts to establish the standard determinants of drug prices available at the time of negotiation. These findings need to be confirmed in other countries where price negotiations are in place. Moreover, further investigations may verify whether outcome data obtained after drug marketing would improve the correlation between prices and therapeutic benefit., Competing Interests: Competing interests: FP has received personal fees unrelated to the work presented in this article from Bayer, Ipsen, Astra Zeneca, Bristol Myers Squibb, Sandoz, Incyte, Celgene, Pierre Fabre, Janssen-Cilag., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2019
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17. HR+/HER2- Metastatic Breast Cancer: Epidemiology, Prescription Patterns, Healthcare Resource Utilisation and Costs from a Large Italian Real-World Database.
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Piccinni C, Dondi L, Ronconi G, Calabria S, Pedrini A, Esposito I, Martini N, and Marangolo M
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols economics, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Aromatase Inhibitors economics, Aromatase Inhibitors therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms epidemiology, Cohort Studies, Databases, Factual trends, Female, Health Resources trends, Humans, Italy epidemiology, Middle Aged, Retrospective Studies, Breast Neoplasms economics, Databases, Factual economics, Health Care Costs trends, Health Resources economics, Patient Acceptance of Health Care, Receptor, ErbB-2
- Abstract
Background and Objective: Breast cancer is the second leading cause of cancer death worldwide. The economic burden of breast cancer is crucial for the sustainability of healthcare systems. The objective of this study was to estimate the burden of HR+/HER2- metastatic breast cancer (MBC) in Italy, in terms of incidence, prescription patterns, healthcare resource utilisation and costs for the National Health System (NHS)., Methods: A cohort study based on healthcare administrative data (ReS database), covering > 10 million Italians, was performed. Incident cases of HR+/HER2- MBC were identified among adult women in 2013. The cohort was followed-up for 2 years to describe healthcare utilisation and integrated costs (pharmaceuticals, hospitalisations and outpatient services) for NHS. Prescription patterns were described as first-line choice and therapeutic changes. Specific therapeutic changes were used as proxies of disease progression. A survival analysis was performed to estimate the time from diagnosis to first disease progression., Results: Of 5174,723 women, 355 cases of de novo HR+/HER2- MBC were selected (incidence: 6.9 per 100,000). During the 1st follow-up year, they generated an average cost of €7543, whereas €4834 in the 2nd year. The 85.9% received a monotherapy, while the 14.1% received a combination therapy. The most used monotherapy was nonsteroidal-aromatase-inhibitors (45.9%), while the most prescribed combination was tamoxifen + luteinizing hormone releasing hormone (LHRH) analogues (6.2%). Therapeutic changes occurred in 45.4% of patients, especially from chemotherapy to nonsteroidal-aromatase-inhibitors, after an average of 276.8 days from the first treatment. Disease progression was identified in 22.5% of patients occurring after a mean 13 ± 6 months from diagnosis., Conclusions: This detailed picture of HR+/HER2- MBC, based on real-world data, could be helpful in health technology assessment and expenditure forecasts of future therapeutic strategies for this condition in Italy.
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- 2019
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18. A real-world study on unmet medical needs in triptan-treated migraine: prevalence, preventive therapies and triptan use modification from a large Italian population along two years.
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Piccinni C, Cevoli S, Ronconi G, Dondi L, Calabria S, Pedrini A, Esposito I, Favoni V, Pierangeli G, Cortelli P, and Martini N
- Subjects
- Adult, Cohort Studies, Disabled Persons, Female, Humans, Italy epidemiology, Longitudinal Studies, Male, Middle Aged, Migraine Disorders epidemiology, Migraine Disorders prevention & control, Prevalence, Health Services Needs and Demand statistics & numerical data, Migraine Disorders drug therapy, Tryptamines administration & dosage
- Abstract
Background: Although migraine is a disabling neurological condition that causes important disability, it remains an area of underdiagnosis and undertreatment worldwide. The aim of this study was to depict the burden of the unmet medical needs in migraine treated with triptans in a large Italian population., Methods: A 2-year longitudinal analysis of migraineurs with unmet medical needs on treatment with triptans was performed. The studied cohort consisted of subjects with ≥4 triptan dose units per month, selected from the general population These patients were stratified into: possible Low-Frequency Episodic Migraine (pLF-EM: 4-9 triptan dose units per month), possible High-Frequency Episodic Migraine (pHF-EM: 10-14 triptan dose units per month) and possible Chronic Migraine (pCM:> 14 triptan dose units per month). The first follow-up year was analysed to describe the use of preventive therapies, the second year to describe the ≥50% reduction in triptan use., Results: Of 10,270,683 adults, 8.0 per 1000 were triptan users and, of these, 38.2% were migraineurs with unmet medical needs, corresponding to 3.1 per 1000 adults. By stratifying for the number of triptan dose units per month, 72.3% were affected by pLF-EM, 17.4% by pHF-EM, and 10.3% by pCM. In this cohort, 19.1% of individuals used oral preventive drugs and 0.1% botulinum toxin. Triptan use reduction was found in 22.3% individuals of the cohort, decreasing with the intensification of need levels (25.8% pLF-EM, 13.6% pHF-EM, 12.0% pCM)., Conclusions: This real-life analysis underlined that the unmet medical needs concern a large part of patients treated with triptans and there is an undertreatment with preventive therapies whose benefit is insufficient, which may be due to the lack of effective preventive strategies, probably still reserved to severe patients. This study allows forecasting the actual impact of newest therapeutic strategies aimed to fill this gap.
- Published
- 2019
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19. [Facts and figures of clinical pathways in Italy: results from the PDTA Net project.]
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Piccinni C, Calabria S, Ronconi G, Dondi L, Pedrini A, Esposito I, Marangolo M, Maggioni AP, and Martini N
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- Databases, Factual, Humans, Italy, Critical Pathways statistics & numerical data, Delivery of Health Care statistics & numerical data
- Abstract
The approval of clinical pathways (CPWs) represents a key step to focus the care management on the patient. The PDTA Net project, by ReS Foundation and CINECA, aims to create a reference tool to study how the local organizational models influence healthcare and clinical outcomes. The article shows the analysis of all CPWs approved by Italian Regions and Autonomous Provinces until 31/12/2018. The search for documents was performed on the institutional websites through specific keywords. CPWs were filled into a database, according to the Region, publication year, disease of interest (distinguishing between chronic diseases with high epidemiological impact and rare diseases) and relevant clinical area. All documents were analyzed by geographical and temporal distribution, the latter also according to ministerial measures. From 2005 to 2018, 536 Regional CPWs were approved (316 for chronic diseases with a high epidemiological impact and 220 for rare diseases). The Regions with the highest number of CPWs of chronic diseases were Umbria (34 CPWs) and Piemonte (33). The most addressed clinical areas were: oncology (72), neurology (60), cardiology (34) and metabolic disorders (22). The most issued diseases were: diabetes (17), trauma/polytrauma (15), chronic obstructive pulmonary disease and multiple sclerosis (12 each), stroke (11), rheumatoid arthritis, breast cancer and colorectal neoplasms (10 each). The publication of the documents was affected by ministerial measures (Balduzzi Law, National Chronicity Plan, Diabetic Disease Plan and National Dementia Plan). The majority of CPWs on rare diseases was retrieved in Regions with activated Rare Disease Networks: Lombardia (110 CPWs), Lazio (64) and Toscana (17). This study showed that, to date, in Italy there are several CPWs published at Regional level, nevertheless their structure and application are heterogeneous and strongly influenced by the National Plans. All analyzed documents are available through the web platform of the project https://fondazioneres.it/pdta/. This project could be useful for health system stakeholders, in order to encourage the transition to new health governance and making CPWs effective governance tools.
- Published
- 2019
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20. Increased incidence of cutaneous melanoma in organ transplant recipients based on a single-centre longitudinal study in Rome, Italy.
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Fania L, Abeni D, Esposito I, Spagnoletti G, Citterio F, Castriota M, Ricci F, Apponi F, Moro F, Mazzanti C, De Simone C, and Peris K
- Subjects
- Female, Hospitals, University, Humans, Incidence, Italy epidemiology, Kidney Transplantation methods, Liver Transplantation methods, Longitudinal Studies, Male, Melanoma pathology, Melanoma surgery, Middle Aged, Prognosis, Retrospective Studies, Risk Assessment, Skin Neoplasms pathology, Skin Neoplasms surgery, Survival Analysis, Melanoma, Cutaneous Malignant, Kidney Transplantation adverse effects, Liver Transplantation adverse effects, Melanoma epidemiology, Skin Neoplasms epidemiology, Transplant Recipients statistics & numerical data
- Published
- 2018
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21. Epidemiology and antibiotic resistance in a large Italian teaching hospital.
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Esposito S, Pascale R, Esposito I, Noviello S, Russo E, Simone GD, Vitolo M, Rega MR, and Massari A
- Subjects
- Acinetobacter Infections microbiology, Acinetobacter baumannii isolation & purification, Cross Infection epidemiology, Cross Infection microbiology, Hospitals, Teaching, Humans, Italy epidemiology, Klebsiella Infections microbiology, Klebsiella pneumoniae isolation & purification, Microbial Sensitivity Tests, Pseudomonas Infections microbiology, Pseudomonas aeruginosa isolation & purification, beta-Lactamases analysis, Acinetobacter Infections epidemiology, Acinetobacter baumannii drug effects, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Bacterial, Klebsiella Infections epidemiology, Klebsiella pneumoniae drug effects, Pseudomonas Infections epidemiology, Pseudomonas aeruginosa drug effects
- Abstract
We focused our attention on susceptibility profile of Acinetobacter spp., Pseudomonas spp., and Klebsiella spp. isolated from biological specimens at the University Hospital of Salerno between June 2011 and October 2012. Acinetobacter, with a prevalence of Acinetobacter baumannii (97%) presented a high range of resistance to the antimicrobials considered, excluding colistin (COL). Klebsiella spp. isolates, with a prevalence of Klebsiella pneumoniae (90%), presented a variable pattern of resistance [from 9·8% for COL to 50% for levofloxacin (LEV)]. Extended-spectrum beta-lactamases production was detected in 15% of isolates. Most Pseudomonas isolates were P. aeruginosa with a high rate of resistance (95% to amoxicillin/clavulanate and trimethoprim/sulfamethoxazole, and <50% to the other antibiotics). Colistin remained the most effective drug tested. This study provided useful information of the local bacterial epidemiology hopefully permitting to establish a more effective empirical therapy, preventing the inappropriate use of antibacterial agents and possibly limiting the diffusion of antibacterial resistance.
- Published
- 2015
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22. Monoclonal gammopathy of undetermined significance in patients with psoriasis: is it really a side effect of biological therapy?
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Conti A, Esposito I, Lasagni C, Miglietta R, Padalino C, Fabiano A, and Pellacani G
- Subjects
- Adalimumab, Adult, Aged, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Etanercept, Female, Humans, Immunoglobulin G therapeutic use, Infliximab, Interleukin-12 antagonists & inhibitors, Interleukin-23 antagonists & inhibitors, Italy epidemiology, Male, Middle Aged, Monoclonal Gammopathy of Undetermined Significance epidemiology, Psoriasis epidemiology, Receptors, Tumor Necrosis Factor therapeutic use, Retrospective Studies, Tumor Necrosis Factor-alpha antagonists & inhibitors, Ustekinumab, Biological Therapy, Monoclonal Gammopathy of Undetermined Significance etiology, Psoriasis drug therapy
- Abstract
Moderate-to-severe psoriasis is treated using biological drugs targeting cytokines involved in the pathogenesis of the disease, such as tumor necrosis factor alpha (TNF-α) (adalimumab, infliximab, etanercept) and interleukin 12/23 (IL 12/23) (ustekinumab). There is a slight risk of developing hematological malignancies, such as monoclonal gammopathy of undetermined significance (MGUS) with anti TNF-α agents. There are no data available on anti-IL12/23 drugs. This retrospective study of data from 191 patients describes the appearance and follow-up of MGUS in three patients with psoriasis receiving long-term biological therapy. Since the appearance of MGUS occurred after about 6 years of anti-TNFα treatment in only three subjects, it was deemed unlikely to be due to the biological treatment. The decision not to suspend biological therapy after the appearance of MGUS was taken after careful assessment of the possible risks and benefits., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2014
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23. Endoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) family members in a Southern Italian region.
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Esposito I, de Bellis M, de Leone A, Rossi GB, Selvaggi F, Di Maio M, Musto D, Tracey MC, Marone P, Esposito P, Tempesta A, and Riegler G
- Subjects
- Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Female, Follow-Up Studies, Humans, Incidence, Italy epidemiology, Male, Patient Compliance, Retrospective Studies, Young Adult, Colonoscopy methods, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Family, Genetic Predisposition to Disease, Population Surveillance methods
- Abstract
Background: Surveillance in hereditary non-polyposis colorectal cancer (HNPCC) family members recommends baseline colonoscopy starting at age 20 and then surveillance colonoscopy every 1-2 years., Aims: To verify adherence to the guidelines for HNPCC family members enrolled in endoscopic surveillance., Methods: Data regarding 11 HNPCC families was retrieved from our database. Excluding 11 probands, 106 family members were evaluated and 40 underwent surveillance., Results: At baseline colonoscopy, 7 colorectal cancers (CRC), 14 polyps (PO) [1 inflammatory, 2 hyperplastic, 10 adenomas with low grade dysplasia (LGD-AD) and 1 adenoma with high-grade dysplasia (HGD-AD)] were diagnosed in sixteen individuals. Twenty-eight HNPCC family members underwent endoscopic surveillance, with a total of 94 surveillance colonoscopies. Of these, 45 were positive (4 CRC, 3 inflammatory PO, 34 hyperplastic PO, 21 LGD-AD and 5 HGD-AD). Mean time between two consecutive surveillance colonoscopies was 24.6 months (range 4-168). Median time to first positive surveillance colonoscopy was 84 months for HNPCC family members with negative baseline colonoscopy, and 60 months for those with positive baseline colonoscopy (p=0.21)., Conclusions: Our data suggests that surveillance colonoscopy every 2 years is adequate to diagnose advanced lesions in HNPCC family members, and improves their compliance with surveillance., (Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2010
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24. Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: an observation on non-absorbable antibiotics.
- Author
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Esposito I, de Leone A, Di Gregorio G, Giaquinto S, de Magistris L, Ferrieri A, and Riegler G
- Subjects
- Adolescent, Adult, Aged, Diagnosis, Differential, Female, Humans, Intestinal Diseases diagnosis, Intestinal Diseases epidemiology, Intestinal Diseases microbiology, Irritable Bowel Syndrome diagnosis, Italy epidemiology, Male, Middle Aged, Prevalence, Anti-Bacterial Agents administration & dosage, Breath Tests, Intestinal Diseases drug therapy, Intestine, Small microbiology, Irritable Bowel Syndrome microbiology, Lactulose analysis
- Abstract
Aim: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO., Methods: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis., Results: When the patients underwent a "breath test", 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1,200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative "breath test" one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, "breath test" remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative "breath test" in one patient only., Conclusion: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a "breath test" with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO.
- Published
- 2007
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25. [Incidence of the so-called minor pollens in the Naples area].
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Granata A, Manzi F, Zannini D, D'Ettore N, and Esposito I
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- Adolescent, Adult, Air Pollution, Female, Humans, Italy, Male, Middle Aged, Radioallergosorbent Test, Respiratory Hypersensitivity epidemiology, Skin Tests, Pollen immunology, Respiratory Hypersensitivity immunology
- Abstract
The data concerning 2500 allergic patients are analysed and the low incidence of so-called "minor pollens" in respiratory allergopathies is documented. Moreover a frequent association of positivity with the so-called "major allergens" (Grass, Parietaria, Dermatophagoides) was observed. Specific hyposensitizing therapy is advised only in carefully selected patients, those showing perfect agreement between allergological data and clinical symptomatology.
- Published
- 1988
26. The precision of statistics of international migrations--a study of flows between Italy and the Federal Republic of Germany.
- Author
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Bretz M, Esposito I, and Fleischer H
- Subjects
- Demography, Developed Countries, Europe, Germany, West, Italy, Population, Population Dynamics, Research, Research Design, Data Collection, Emigration and Immigration, Evaluation Studies as Topic, Population Characteristics, Reproducibility of Results
- Published
- 1987
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