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In this article, we analyse the interplay between forced migrants' retrospective expectations and their current experiences in the host country, and how this interaction informs their aspirations in relation to their potential life trajectories. By zooming in on the Austrian and Italian cases derived from qualitative data, this article investigates forced migrants' retrospective perspectives on the 'good life' in (imagined) Europe and their experienced-informed perspectives of the host country context—reception policies—after migration by tracing individuals' self-reported perceptions of life aspirations over the course of their migration journey. By applying the aspirations-capability framework , our analysis traces what 'happens' after people have submitted their asylum applications. In this way, this research sheds light on the process of adapting to a new context with gravely restricted capabilities and how this affects people's life aspirations. By doing so, we demonstrate that aspirations are not only dynamic and flexible, but capabilities also change due to the structural confines of national asylum procedures. This study therefore brings an innovative perspective to study life aspirations and capabilities by showing the importance of reflecting not only aspirations but also the (in)capability of acting in the present which informs the process of revisiting original life aspirations for individuals seeking asylum. This process begins after the arrival, based on changes in their capabilities, specifically the national asylum structures that confine them. [ABSTRACT FROM AUTHOR]

Aim: Inflammatory reactions are essential for wound healing and a physiological response to injuries. Excessive inflammation delays the transition to the proliferation phase, thus representing one key aspect in the development of wound healing disorders. Here, we monitored inflammatory responses in physiological and delayed wound healing. Method: Gene expression and dermal interstitial fluid (dISF) abundance of inflammatory and regeneration factors were monitored in superficial wounds of different healing stages in pigs. Inflammation was induced in some wounds by using resiquimod, a TLR7/8 agonist, to prolong the inflammatory phase for up to 6 days after wounding. Results / Discussion: During physiological wound healing, pro-inflammatory cytokines (IL6, CXCL8) and prostaglandin E2 showed a peak of abundance in the dISF on day 2 after wounding and declined back to baseline on day 6. Wounds induced with resiquimod for 6 days showed only 20% healing rate as compared to 75% in control wounds. Further, resiquimod induction significantly increased gene expression, production as well as secretion of pro-inflammatory factors (IL6, CXCL8, PGE2). Gene expression levels of regeneration markers such as TGFB1 and HIF1A were also upregulated in inflamed wounds. Histological analysis demonstrated decreased re-epithelization in resiquimod induced wounds, but increased infiltration of immune cells. Resiquimod induction led to a sustained inflammatory response until at least day 6 post wounding. Conclusion: This study gave insight into the time and location dependent expression, production and secretion of relevant cytokines, growth factors and markers of tissue regeneration in the context of physiological as well as delayed wound healing. [ABSTRACT FROM AUTHOR]