17 results on '"D'Anna, G"'
Search Results
2. Why nursing students have sex without condom? A study in the university of Palermo.
- Author
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Santangelo, O. E., Provenzano, S., Grigis, D., Terranova, A., D'Anna, G., Armetta, F., Giordano, D., Gianfredi, V., and Firenze, A.
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UNSAFE sex ,NURSING student attitudes ,SEXUALLY transmitted diseases ,SEX customs ,UNIVERSITIES & colleges ,LOGISTIC regression analysis - Abstract
Aims. Evaluation of the knowledge and behavioral risks related to sexually transmitted infections (STIs) among the student population of the degree course in nursing at the University of Palermo. Materials and Methods. An anonymous online a survey was provided to students that investigate to socio-demographic information, sexual habits and the level of knowledge of the STIs. Multivariable logistic regression was performed, considering it as a dependent variable "Do you permanently have unprotected sex (without a condom)? Yes", in order to evaluate the role of the variables of the questionnaire. Results are expressed as adjusted Odds Ratio (aOR). Results. The sample size consists of 405. The average age of the sample is 21.65 years (standard deviation±3.24). The analysis shows that the risk of having permanently unprotected sex (without condom) is significantly associated with the following variables: "Are you engaged or single? Engaged" (aOR 3.24, 95% CI 1.66 - 6.33); "Sexual orientation. Homosexual or Bisexual (aOR 4.45, 95% CI 1.30 - 15.29); "Have you occasionally had unprotected sex (without a condom)? Yes" (aOR 5.09, 95% CI 2.69 - 9.62); "How would you define your knowledge of sexually transmitted diseases? Good" (aOR 2.07, 95% CI 1.05 - 4.08); "How would you define your knowledge about contraceptive methods? Good" (aOR 2.51, 95% CI 1.23 - 5.15); "Have you or have you ever had a sexually transmitted disease? Yes (aOR 4.43, 95% CI 1.71 - 11.53); "Do you know that men can also undergo HPV vaccination? Yes" (aOR 2.57, 95% CI 1.03 - 6.40); "Age. As the unit increase" (aOR 1.14, 95% CI 1.02 - 1.26). Conclusions. These results highlight the importance of involving university students in programs aimed at improving the knowledge in terms of STIs and increase of Sexual and reproductive health. Further, because STIs prevention is based mainly on human behavior, tailored intervention is needed especially because behavior change remains a complex challenge. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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3. Urban MEMS based seismic network for post-earthquakes rapid disaster assessment.
- Author
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D'Alessandro, A., Luzio, D., and D'Anna, G.
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MICROELECTROMECHANICAL systems ,SEISMIC networks ,ACCELEROMETERS ,EARTHQUAKES ,EMERGENCY management ,NATURAL disaster warning systems - Abstract
In this paper, we introduce a project for the realization of the first European real-time urban seismic network based on Micro Electro-Mechanical Systems (MEMS) technology. MEMS accelerometers are a highly enabling technology, and nowadays, the sensitivity and the dynamic range of these sensors are such as to allow the recording of earthquakes of moderate magnitude even at a distance of several tens of kilometers. Moreover, thanks to their low cost and smaller size, MEMS accelerometers can be easily installed in urban areas in order to achieve an urban seismic network constituted by high density of observation points. The network is being implemented in the Acireale Municipality (Sicily, Italy), an area among those with the highest hazard, vulnerability and exposure to the earthquake of the Italian territory. The main objective of the implemented urban network will be to achieve an effective system for post-earthquake rapid disaster assessment. The earthquake recorded, also that with moderate magnitude will be used for the effective seismic microzonation of the area covered by the network. The implemented system will be also used to realize a site-specific earthquakes early warning system. [ABSTRACT FROM AUTHOR]
- Published
- 2014
4. Biology of red mullet, Mullus barbatus (L. 1758), in the Gulf of Castellammare (NW Sicily, Mediterranean Sea) subject to a trawling ban.
- Author
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Sieli, G., Badalucco, C., Di Stefano, G., Rizzo, P., D'Anna, G., and Fiorentino, F.
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MULLIDAE ,MULLUS barbatus ,FISH reproduction ,FISH populations ,TRAMMEL netting - Abstract
Summary Under-or non-exploited areas are useful to aid in evaluating the potential productivity of fish stocks for sustainable fisheries. The Gulf of Castellammare (NW Sicily), where trawling has been banned since 1990, is a good site to study the biology and dynamics of low impacted fish populations. A total of 661 (595 female and 66 male) specimens of red mullet Mullus barbatus (95-245 mm total length, TL) obtained by monthly sampling from trammel net artisanal fishery, was collected in the Gulf of Castellammare from April 2006 to June 2007. Mature females occurred from April to September, with a peak in May. The mean Gonado-somatic index (GSI) also showed a May peak for both sexes. From Sagittae (642) readings the age structure ranged from age class I to VII in females and I to V in males. Female growth parameters, estimated according to the classic von Bertalanffy model, were: L
∞ = 221.2 ± 11.51 mm standard error (SE), ky −1 =0 y = −0.94 ± 0.38 SE. The growth performance index (ø' = 2.27) was included in the range of values obtained by hard structure readings in the Central Mediterranean. Natural mortality ( My −1 ) of females estimated by different methods ranged between 0.62 and 0.87 (mean value = 0.71 ± 0.06 SE). [ABSTRACT FROM AUTHOR]- Published
- 2011
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5. Food partitioning and diet temporal variation in two coexisting sparids, Pagellus erythrinus and Pagellus acarne.
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Fanelli, E., Badalamenti, F., D'Anna, G., Pipitone, C., Riginella, E., and Azzurro, E.
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SPARIDAE ,COEXISTENCE of species ,GASTROINTESTINAL content analysis ,ANIMAL species ,PREDATION ,POLYCHAETA - Abstract
Resource partitioning in two congeneric sparids, pandora Pagellus erythrinus and axillary seabream Pagellus acarne, was investigated using stomach content analysis integrated with data on stable isotopes ( δN and δC). The study was carried out on coastal muddy bottoms in the Gulf of Castellammare (southern Tyrrhenian Sea, western Mediterranean Sea) in seasons (autumn, November 2004; winter, March 2005; spring, early June 2005), at depths between 50 and 100 m. Stomach content analysis suggested low trophic niche overlap between the two species. Pagellus erythrinus mainly preyed on strictly benthic organisms (polychaetes, brachyuran crabs and benthic crustaceans). Although it consumed benthic prey, P. acarne preferred suprabenthic prey such as peracarid crustaceans from the benthic boundary layer a few metres above the bottom. The two species showed different isotopic values, with P. erythrinus exhibiting higher δN and more enriched δC than P. acarne, in accordance with its marked benthic behaviour and high predation on carnivore polychaetes. Significant temporal variability in both diet and isotopic values caused trophic differences between the two species. The autumn and winter diet differed from the spring diet and the trophic levels of both species increased from autumn and winter to spring, in accordance with variations in food availability and changes in prey δN and δC. These temporal variations may be linked to an increase in energy requirements for reproduction, together with the differing availability of preferred prey throughout the year. Significantly, lower δC was recorded in fishes collected in winter (March), suggesting the influence of river inputs as a source of particulate organic matter in this zone after the flooding season. In conclusion, these sympatric congeneric fish species displayed clear food partitioning throughout the temporal scale analysed. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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6. Weight-length relationships and condition factor trends for thirty-eight fish species in trawled and untrawled areas off the coast of northern Sicily (central Mediterranean Sea) V. M. Giacalone et al. WLR, condition factor and trawl-ban.
- Author
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Giacalone, V. M., D'Anna, G., Badalamenti, F., and Pipitone, C.
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FISHERY gear , *MARINE species diversity ,FISH weight - Abstract
This paper reports the weight-length relationship (WLR) for thirty-eight fish species from the Gulf of Castellammare (NW Sicily, Mediterranean Sea). A total of 59 870 fish were collected and measured during four seasonal trawl surveys carried out in 2005 at 10 to 200 m depth. The b parameter of the WLRs ranged from 1.79 ( Cepola macrophthalma) to 3.56 ( Conger conger). Significant differences in both a and b values among seasons were detected for eight species. Moreover, the condition factors (as weight-at-length) of Merluccius merluccius and Mullus barbatus were compared in different area/year combinations characterized by the presence or absence of trawling impact. While M. barbatus showed a higher condition factor in trawled areas/years, possibly due to density-dependent factors linked to the increased biomass in the no-trawl area, no such link was detected in M. merluccius. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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7. Effect of simulated macroalgae on the fish assemblage associated with a temperate reef system
- Author
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Vega Fernández, T., D'Anna, G., Badalamenti, F., and Pérez-Ruzafa, A.
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ALGAE , *FISH ecology , *HABITATS , *BIODIVERSITY , *BIOMASS , *ARTIFICIAL reefs , *SEAGRASSES - Abstract
Abstract: Increased habitat complexity is supposed to promote increased diversity, abundance and biomass. This study tested the effect of the macroalgal cover on temperate reef fishes by mimicking macroalgae on artificial reefs in NW Sicily (Mediterranean Sea). Macroalgal cover affected reef fishes in different ways and independently of intrinsic temporal trends. The fish assemblages of manipulated and control artificial reef units differed in the relative abundances of the associated species, but little in species composition. In line with studies in seagrass habitats, fishes were most abundant in reefs covered by artificial macroalgae. Three species (Boops boops, Serranus scriba and Symphodus ocellatus) exhibited consistently greater abundance on vegetated reef units than on control reef units. The total number of species and the abundance of three particular species (S. scriba, S. ocellatus and Thalassoma pavo) displayed temporal trends which were independent on short and large temporal scales. Only fish total biomass and one species (Spicara flexuosa) displayed strong effects of interaction among the experimental factors. Mechanisms to explain these findings are discussed from observational evidence on habitat use and interactions among multiple species. This study highlights that manipulative experiments involving repeated sampling of fish in artificial habitats appear to be a valid approach to study fish-habitat relationships in fluctuating environments. It is also concluded that macroalgae mimics may serve as a tool for restoring lost marine vegetated habitats when current human-induced conditions prevent the recovery of pristine macroalgal stands. [Copyright &y& Elsevier]
- Published
- 2009
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8. Changes in spawning-stock structure and recruitment pattern of red mullet, Mullus barbatus, after a trawl ban in the Gulf of Castellammare (central Mediterranean Sea).
- Author
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Fiorentino, F., Badalamenti, F., D'Anna, G., Garofalo, G., Gianguzza, P., Gristina, M., Pipitone, C., Rizzo, P., and Fortibuoni, T.
- Subjects
MULLUS barbatus ,MULLIDAE ,SPAWNING ,TRAWLING - Abstract
Fiorentino, F., Badalamenti, F., D’Anna, G., Garofalo, G., Gianguzza, P., Gristina, M., Pipitone, C., Rizzo, P., and Fortibuoni, T. 2008. Changes in spawning-stock structure and recruitment pattern of red mullet, Mullus barbatus, after a trawl ban in the Gulf of Castellammare (central Mediterranean Sea). – ICES Journal of Marine Science, 65: 1175–1183.The increase in biomass of red mullet, Mullus barbatus, in the Gulf of Castellammare (northwestern Sicily, central Mediterranean) after a 14-year trawl ban, prompted us to compare the spawning-stock structure and the recruitment pattern before and after the closure. Datasets obtained from three experimental trawl surveys were available before the ban (April and September 1985; April–May 1986) and four post-ban (September and November 2004; March and May 2005). Spawning-stock biomass increased significantly after the ban. Moreover, females at depths >50 m in the post-ban period were larger than those collected before the ban at the same depth. The recruitment pattern of the population also changed. Notably, recruit numbers increased and recruitment occurs over a broader period. The increase in biomass after the trawl ban seems to be the result of a combination of different processes, mainly associated with the lowering of fishing mortality. A positive trend in sea surface temperature in the area may have played a role too. [ABSTRACT FROM PUBLISHER]
- Published
- 2008
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9. FADs influence on settlement and dispersal of the young-of-the-year greater amberjack ( Seriola dumerili).
- Author
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Sinopoli, M., D'Anna, G., Badalamenti, F., and Andaloro, F.
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FISHES , *FISHERIES , *FISHERY management , *AQUATIC animals , *MARINE animals , *MARINE biology research - Abstract
FADs are fish aggregating devices applied worldwide over the centuries to increase fish catch. However, the utilisation of such floating devices can influence dispersion patterns of some fish species. At present it is still not clear if FADs play a role in the shoreward migrations of juvenile fish of reef associated species, such as the greater amberjack Seriola dumerili. In this study, we hypothesised that FADs located along a distance gradient from the shore might lead the greater amberjack inshore. In such case, mean abundance of S. dumerili should decrease over time in offshore FADs and increase in inshore FADs. To test the hypothesis three FAD systems were positioned in the Gulf of Castellammare (Sicily, Italy), between July and September 2001, at increasing distances from the coast. During the study period, five visual censuses were carried out within FADs fields. During the first sampling period, no significant difference in abundance and size of juvenile S. dumerili was found between the three FAD systems. All the other sampling periods reported higher abundances and sizes in the offshore FADs than in the two inshore FADs. The findings suggest that FAD systems might be exerting two different effects on young of the year (YOY) S. dumerili distribution: (a) offshore FADs tend to retain associated fish for longer periods of time, (b) coastal FADs favour the transition of YOY S. dumerili from the pelagic to the benthic domain. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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10. Releasing of hatchery-reared juveniles of the white seabream Diplodus sargus (L., 1758) in the Gulf of Castellammare artificial reef area (NW Sicily)
- Author
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D'Anna, G., Giacalone, V.M., Badalamenti, F., and Pipitone, C.
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HATCHERY fishes , *DIPLODUS , *AQUACULTURE - Abstract
A pilot experiment of marine ranching using hatchery-reared juveniles of white seabream, Diplodus sargus, was made in the Gulf of Castellammare (NW Sicily). The research aimed at evaluating (i) if artificial reefs are suitable for the settlement of reared young seabreams, (ii) what are the main causes of mortality and (iii) the growth rate of released fishes in the open sea. A total of 6930 tagged cultured juvenile white seabreams (305 days old) were released in an artificial reefs (AR) area. Underwater visual census, sightings and recaptures were used as a source of data for estimating abundance and size of released fishes. The survey lasted 15 months and was carried out in artificial (AR, breakwaters and harbours) and natural (river mouths, rocky bottoms and Posidonia oceanica meadows) coastal habitats of the Gulf. A few days after the release, more than 90% of the tagged seabreams left AR and moved mainly towards harbours and breakwaters, which resulted to be particularly suitable for their settlement and growth. The recapture was 8.2% of the released stock. During the first days after releasing, the main ascertained sources of mortality were professional fishing (6.7%) and predation by conger eel, Conger conger (1.1%). A behavioural deficit of the reared seabreams in the use of refugia and food was observed in the initial period following the release. The results obtained provide some management suggestion for the feasibility of marine ranching initiatives involving hatchery-reared fishes. [Copyright &y& Elsevier]
- Published
- 2004
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11. Are artificial reefs comparable to neighbouring natural rocky areas? A mollusc case study in the Gulf of Castellammare (NW Sicily).
- Author
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Badalamenti, F., Chemello, R., D'Anna, G., Ramos, P. Henriquez, and Riggio, S.
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ARTIFICIAL reefs ,REEFS ,MOLLUSKS ,ANIMAL species - Abstract
Mollusc assemblages of three concrete artificial reefs (ARs) in the Gulf of Castellammare were compared with those of two nearby natural reefs (NRs). The reefs were located in areas characterized by different degrees of water transparency, with average annual Secchi disk visibility ranging from clear (>20 m) to turbid waters (<6 m). In spring 1995, 28 samples of 400 cm2 were scraped off the reefs at depths of 16–22 m (20 from ARs; 8 from NRs), which yielded a total of 116 species and 1084 specimens of molluscs. The assemblage derived from a NR in clear water showed the highest diversity, species richness, and evenness, while the highest number of specimens and dominance values were observed at an AR in turbid water. The lowest values of diversity and species richness were found at ARs in turbid water and the lowest number of specimens at a NR in turbid water. Comparison of the five reefs showed significant differences in average number of species and in diversity values, while differences in the number of specimens were not significant. Factorial correspondence analysis showed a pattern that was strongly polarized along the first axis by the NR in clear water and by the AR in turbid water. The most distinctive feature was the dominance of Bittium latreillii at AR sites. Three years after deployment, mollusc assemblages of ARs in the Gulf remain entities that are distinct from those of nearby natural reefs. However, the potential of the assemblages in terms of density of individuals is comparable to that of natural reefs. Copyright 2002 International Council for the Exploration of the Sea. Published by Elsevier Science Ltd. All rights reserved. [ABSTRACT FROM PUBLISHER]
- Published
- 2002
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12. Short-term effectiveness and safety of abrocitinib in adults with moderate-to-severe atopic dermatitis: results from a 16-week real-world multicenter retrospective study - il AD (Italian landscape atopic dermatitis).
- Author
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Gargiulo L, Ibba L, Alfano A, Malagoli P, Amoruso F, Balato A, Barei F, Burroni AG, Caccavale S, Calzavara-Pinton P, Esposito M, Fargnoli MC, Ferrucci SM, Foti C, Girolomoni G, Gola M, Guanti MB, Gurioli C, Magliulo M, Maurelli M, Morrone P, Musumeci ML, Napolitano M, Ortoncelli M, Patruno C, Piraccini BM, Pezzolo E, Ribero S, Rossi M, Savoia P, Sciarrone C, Tirone B, Vaccino M, Veronese F, Costanzo A, and Narcisi A
- Subjects
- Humans, Retrospective Studies, Female, Male, Adult, Middle Aged, Treatment Outcome, Italy, Pyrimidines adverse effects, Pyrimidines administration & dosage, Sulfonamides therapeutic use, Sulfonamides adverse effects, Aged, Young Adult, Dermatitis, Atopic drug therapy, Dermatitis, Atopic pathology, Severity of Illness Index
- Abstract
Aim: Abrocitinib is a JAK-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis (AD). We conducted a 16-week multicenter retrospective study to assess the short-term effectiveness and safety of abrocitinib in patients with moderate-to-severe AD., Our retrospective study included 85 adult patients from 14 Italian Dermatology Units affected by moderate-to-severe AD treated with abrocitinib 100/200 mg., Methods: Effectiveness of abrocitinib at weeks 4 and 16 was assessed by using the Eczema Area and Severity Index (EASI), the Investigator Global Assessment (IGA), the peak pruritus and sleep- Numerical Rating Scale (PP-NRS and S-NRS, respectively)., Results: At week 16, improvement of at least 90% in EASI (EASI90) and IGA 0/1 was observed in 49.4% and 61.2% of patients, respectively. A reduction of at least 4 points in PP-NRS and S-NRS compared with baseline was achieved by 70.6% of patients for both endpoints. No significant safety reports were observed during the study period. Naïve patients had better rates of EASI 90 compared to patients who previously failed dupilumab. Conclusion: Our data confirm the effectiveness of abrocitinib in a real-world setting with better clinical responses at weeks 4 and 16, compared with Phase-III clinical trials. Longer analyses are required to further establish the safety profile of abrocitinib.
- Published
- 2024
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13. Simultaneous mating disruption of two moth pests of the vineyard (Lobesia botrana and Cryptoblabes gnidiella) through a biodegradable sex pheromone dispenser.
- Author
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Ricciardi R, De Fazi L, D'Anna G, Savino F, Ladurner E, Iodice A, Benelli G, and Lucchi A
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- Animals, Vitis, Italy, Sexual Behavior, Animal drug effects, Pest Control, Biological methods, Lobesia botrana, Moths, Sex Attractants
- Abstract
Lobesia botrana (Lepidoptera: Tortricidae) and Cryptoblabes gnidiella (Lepidoptera: Pyralidae) represent a threat to wine production in Mediterranean countries. In recent years, the development of new formulations promoted the spread of pheromone-based mating disruption (MD) as an effective tool for the management of several insect pests in different agricultural contexts. In this study, we investigated the efficacy of an experimental dispenser designed for simultaneous MD of these two pests. The biodegradable double-tube dispenser (Isonet® L CG-BIOX235) was tested for two years in two Italian wine-growing sites, the first in Apulia (Southern Italy), and the second in Tuscany (Central Italy). Isonet® L CG-BIOX235 efficacy was evaluated by testing different doses (i.e., 300, 400, and 500 dispensers/ha), on different varieties (i.e., Aglianico, Syrah, and Viognier), and comparing it with an untreated control. The MD performed using this dispenser significantly reduced the infestation of both L. botrana (i.e., percentage of infested bunches and number of nests per bunch) and C. gnidiella compared to the untreated control, although the occurrence of the latter fluctuated throughout the two-year trials. Overall, although our results underline the possibility of combining the pheromones of the two pests in a single dispenser for their simultaneous MD, they also highlight the need for further studies on some aspects of C. gnidiella biology and consequently improve the MD efficacy against this species., (© 2024. The Author(s).)
- Published
- 2024
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14. Correlations between performance and shift work in the nursing activities: a pilot approach.
- Author
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Vitale E, Lupo R, Fortunato S, Gualano A, Giammarinaro MR, Bardone L, Mea R, Calabrò A, D'Anna G, Della Pietà C, and Germinni F
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- Humans, Italy, Organizational Culture, Surveys and Questionnaires, Shift Work Schedule
- Abstract
Background and Aim of the Work: Performance assessment is a key administrative function and an essential component of organizational quality programs, by quantifying it in relation to set goals, standards, expectations and guides to improvement initiatives. The present study aimed to correlate the nursing performance levels perceived by the nurses themselves with the levels of organizational well-being. Methods. An on-line questionnaire was administered to Italian nurses in order to assess nursing performance, thanks to the Six-Dimension on Nursing performance questionnaire and also the wll-being of nursing organization was explored thanks to the Questionnaire on nursing organization- brief form questionnaire (QISO brief form)., Results: Significant correlations were assessed between the nursing performance sub dimensions on frequency sub scale and each sub-dimensions of the well-being questionnaire (p<.001). Also in Teaching/Collaboration sub-dimension of the quality nursing performance sub scale, positive correlations were recorded with the QISO brief form., Conclusions: Findings were in agreement with the little current literature on this topic, as: the nursing sector might implement reforms and instill an organizational culture in which staff feel they own their profession and will be intimately involved in the vision and mission of their organizations. To help achieve this and improve health services, nurses' organizational engagement enhancement policies should be implemented as an organizational issue requiring the development of strategies for recruiting, attracting and retaining engaged nurses.
- Published
- 2022
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15. COVID-19 infection: comparing the knowledge, attitude and practices in a sample of nursing students.
- Author
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Provenzano S, Santangelo OE, Armetta F, Pesco G, Allegro A, Lampasona M, Terranova A, D'Anna G, and Firenze A
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- Cross-Sectional Studies, Female, Humans, Italy epidemiology, Male, Pandemics, Surveys and Questionnaires, Young Adult, Attitude of Health Personnel, COVID-19 nursing, Clinical Competence, Students, Nursing
- Abstract
Background: SARS-CoV-2 infection is a global health problem that is primarily detected in Italy with progressive increase in cases and deaths. To facilitate the management of the pandemic in Italy, it is essential to understand the level of attention on COVID-19. The aim of the study was to evaluate the knowledge, attitude and practices towards SARS-CoV-2 among the nursing students of University of Palermo during the rapid rise period of the COVID-19 pandemic., Methods: The current study was a cross-sectional study. On-line questionnaires were used for the collection of the data by providing a survey in all nursing students. The questionnaire consisted of two parts: demographics and Knowledge, Attitude and Practices (KAP) survey. A multivariate linear regression model was used and adjusted Odds Ratios (aOR) are presented., Results: 525 students were interviewed and their mean age was 21.8. The overall score indicates good practices among the three courses of study (p=0.025). The Multivariable logistic regression showed that the dependent variable "Practice poor score" is statistically significant associated with these independent variables: "Other country of birth" (aOR 17.7, 95% CI 2.31-136.03), "second" (aOR 2.65, 95% CI 1.21-7.80) and "third" (aOR 2.96, 95% CI 1.31-6.72) year of study, "low perceived health status"(aOR 2.35, 95% CI 1.04-5.30) and "Knowledge poor score (aOR 3.05, 95% CI 1.06-8.77)., Conclusion: Our results suggest that health education programs aimed at improving COVID-19 knowledge are helpful for nursing students to hold optimistic attitudes and maintain appropriate practices.
- Published
- 2020
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16. Antecedent Administration of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists and Survival After Hospitalization for COVID-19 Syndrome.
- Author
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Palazzuoli A, Mancone M, De Ferrari GM, Forleo G, Secco GG, Ruocco GM, D'Ascenzo F, Monticone S, Paggi A, Vicenzi M, Palazzo AG, Landolina M, Taravelli E, Tavazzi G, Blasi F, Infusino F, Fedele F, De Rosa FG, Emmett M, Schussler JM, Tecson KM, and McCullough PA
- Subjects
- Age Factors, Aged, Aged, 80 and over, COVID-19 diagnosis, COVID-19 mortality, Female, Hospital Mortality, Humans, Italy, Male, Middle Aged, Protective Factors, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Angiotensin Receptor Antagonists therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, COVID-19 therapy, Hospitalization
- Abstract
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes the angiotensin-converting enzyme-2 (ACE-2) receptor to enter human cells. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists (ARB) are associated with ACE-2 upregulation. We hypothesized that antecedent use of ACEI/ARB may be associated with mortality in coronavirus disease 2019 (COVID-19). Methods and Results We used the Coracle registry, which contains data of patients hospitalized with COVID-19 in 4 regions of Italy, and restricted analyses to those ≥50 years of age. The primary outcome was in-hospital mortality. Among these 781 patients, 133 (17.0%) used an ARB and 171 (21.9%) used an ACEI. While neither sex nor smoking status differed by user groups, patients on ACEI/ARB were older and more likely to have hypertension, diabetes mellitus, and congestive heart failure. The overall mortality rate was 15.1% (118/781) and increased with age ( P
Trend <0.0001). The crude odds ratios (ORs) for death for ACEI users and ARB users were 0.98, 95% CI, 0.60-1.60, P =0.9333, and 1.13, 95% CI, 0.67-1.91, P =0.6385, respectively. After adjusting for age, hypertension, diabetes mellitus, and congestive heart failure, antecedent ACEI administration was associated with reduced mortality (OR, 0.55; 95% CI, 0.31-0.98, P =0.0436); a similar, but weaker trend was observed for ARB administration (OR, 0.58; 95% CI, 0.32-1.07, P =0.0796). Conclusions In those aged ≥50 years hospitalized with COVID-19, antecedent use of ACEI was independently associated with reduced risk of inpatient death. Our findings suggest a protective role of renin-angiotensin-aldosterone system inhibition in patients with high cardiovascular risk affected by COVID-19.- Published
- 2020
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17. Taking advantage of seagrass recovery potential to develop novel and effective meadow rehabilitation methods.
- Author
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Alagna A, D'Anna G, Musco L, Vega Fernández T, Gresta M, Pierozzi N, and Badalamenti F
- Subjects
- Alismatales growth & development, Ecosystem, Italy, Plant Shoots growth & development, Rhizome, Alismatales physiology, Environmental Restoration and Remediation methods
- Abstract
Seagrasses are among the most threatened biomes worldwide. Until now, seagrass rehabilitation success has reached about 38% overall and more effective approaches to restoration are urgently needed. Here we report a novel method to rehabilitate Posidonia oceanica meadows based on observation of the species' natural recovery after disturbance. Posidonia oceanica rhizomes were transplanted on gabions filled with rocks of selected sizes in order to build a firm substrate with topographic complexity in the relevant scale range to propagules. Five techniques were tested, each involving a different anchoring device. The "slot" technique, which uses a wire-net pocket to retain the cuttings, was the most successful, with survival exceeding 85% after thirty months. Branching allowed final shoot survival to reach 422% of initial planting density. This study shows how an in-depth knowledge of species life history processes provides a suitable foundation for developing effective restoration methods that benefit from species recovery ability., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
- Full Text
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