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Satellite interferometry has recently developed as a powerful tool for monitoring displacements on structures for structural health monitoring (SHM), as it allows obtaining information on past deformation and performing back analysis on structural behavior. Despite the increasing literature on this subject, the lack of protocols for applying and interpreting interferometric data for structural assessment prevents these techniques from being employed alongside conventional SHM. This paper proposes a methodology for exploiting satellite interferometric data aiming at remotely detecting displacements and buildings' criticalities at different levels of analysis, i.e., urban scale and single-building scale. Moreover, this research exploits the capability of satellite monitoring for damage diagnosis, comparing the millimeter scale displacements to information derived from on-site inspections. Different data-driven algorithms were applied to detect seasonal and irreversible components of displacements, such as statistical models for damage identification derived from traditional on-site monitoring. Thus, the proposed methodology was applied to a XVI-century case study located in the city center of Rome (Italy), Palazzo Primoli, and two stocks of COSMO-SkyMed (CSK) images processed through the Small BAseline Subset Differential Interferometry (SBAS-DInSAR) technique were used to assess displacements for an eight-year-long (between 2011 and 2019) monitoring period. [ABSTRACT FROM AUTHOR]

The severe drought that affected large areas of Europe in Spring and Summer 2022 hit the Po valley (northern Italy) with an intense water scarcity crisis. Productive activities, particularly agriculture, suffered the consequences of water shortage, and the coastal regions of the Po Delta underwent extensive saltwater intrusion. By relying on observed discharge records and on precipitation data from reanalysis and climate models, we analyse the 2022 event in the framework of the recent past statistics and in future scenarios. Alongside with a projection of future rainfall regimes on the Po River basin in two climate change scenarios, our analysis shows that persistent negative rainfall anomalies like the ones that characterised the 2022 event, though unlikely to become a typical feature of future climate, could remarkably increase their frequency, particularly in a severe climate change condition. Moreover, their impacts will be magnified by rising temperatures and, in coastal areas, by rising sea level, enhancing the salinisation of agricultural lands and altering the dynamics of transitional ecosystems. While providing a first quantitative assessment of an event that struck a strategic productive and environmental region of the Italian territory, this brief communication points out the importance of a multi-disciplinary, basin-scale approach to climate change adaptation. [ABSTRACT FROM AUTHOR]

Background: Antimicrobials resistance (AMR) is an increasingly serious global health problem, both in terms of clinical implications and economic expenditure. In Italy, there are differences in prescribing rates between regions. We aimed to compare these differences in two Italian provinces: one of Emilia Romagna (north region) and one of Puglia (south region).Methods: The number of antibiotics prescribed packages and the relative expenditure data (year 2015) were obtained. We applied the prescription quality indicators proposed by the European Surveillance of Antimicrobial Consumption for an in-depth analysis.Results: Both consumption and expenditure were higher in the south province. In the Apulian province also the use of parenteral antibiotics was more frequent. The most prescribed antibiotics in both the provinces were: penicillins (combined or not), macrolides, and fluoroquinolones.Conclusion: We observed variability between the north and south province in terms of antibiotics prescription. Overall, our study indicates that antibacterials could be overprescribed. The choice of the right antibiotic continues to be a demanding task for practitioners and much still needs to be done in the fight against AMR, starting from a more appropriate use and interventions aimed at raising awareness of antibiotic resistance. [ABSTRACT FROM AUTHOR]

Purpose: In Italy, the non-commercial trials on medicines are regulated by the Ministry Decree 17 December, 2004. Its intent is of encouraging the independent research for the improvement of clinical practice. We aimed to analyze the main features of the proposals of non-commercial clinical trials on medicines submitted to the Independent Ethics Committee (IEC) of the University Hospital of Bologna in the period 2010–2017. Methods: Data were extracted from IEC registry and were organized with an ad hoc database. The relationships between the variables were examined using contingency tables. When appropriate, we applied the chi-square statistical test for the comparison of the categorical variables. Results: Over the 8-year period, the IEC evaluated 2931 studies, of which 1156 (39.4%) related to clinical trials on medicines; 245 (21.2%) out of the latter were non-commercial ones. A percentage of 49.8 of the trials were of phase II; 137 trials (55.9%) were promoted by hospitals, medical schools or institutes for research, hospitalization and health care. Non-profit organizations and scientific societies were promoters of 88 trials (35.9%). Most phase I and phase II trials received additional support from pharmaceutical companies. Conclusions: Our results show a not negligible industrial influence on non-commercial trials through additional support, mostly to those of phase II. An update of the present legislation on this matter is desirable, adopting clearer rules on the relations sponsor-industry. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this multicenter prospective study was to evaluate efficacy and safety of biosimilar erythropoiesis-stimulating agents (ESAs) vs originator, based on data from clinical practice in patients with chronic kidney disease (CKD).Methods: We collected data of the patients with diagnosis of CKD on conservative treatment from nine Italian structures. Patients were enrolled applying different exclusion criteria, and various individual parameters were registered at the beginning for descriptive analysis. Patients were treated with epoetin alfa, beta, and darbepoetin as originator and epoetin zeta as biosimilar. Hemoglobin levels have been analyzed at baseline and after 3, 6, and 12 months. Descriptive statistics were used to analyze the results.Results: At baseline, 47 patients were in the biosimilar group and 57 in the originator; the basal level of hemoglobin was similar between the groups (mean Hb 9.4 and 9.3 g/dL, respectively). Median age, weight, and comorbidities were almost comparable. After 3 months, 44 patients remained in the biosimilar group and 48 in the originator; hemoglobin increase was significantly greater in patients treated with biosimilar [absolute increase 1.6 vs 1.0 g/dL, p < 0.001]. After 6 and 12 months, number of patients fall furthermore. Hemoglobin levels increased more in the biosimilar group after 6 months (2.1 vs 1.1 g/dL, p < 0.001) and 12 months (2.0 vs 1.0 g/dL, p < 0.001).Conclusions: Biosimilar ESAs have similar risk/benefit profile compared to originators. Our data are in agreement with relevant scientific literature and, on the other hand, they are in contrast with common thought that considers biosimilar less efficacious and less safe than originators. [ABSTRACT FROM AUTHOR]

The study aims to assess Italian consumers’ attitudes towards food risks and seeks to outline their socio-demographic and behavioural characteristics on the basis of their attitudes (self-protectiveandnon-self-protective) towards food risks. Using the Computer-assisted telephone interviewing survey method, a sample of 1000 Italian consumers was interviewed on risk perception issues and general eating habits. Factor analyses on the consumers’ propensities to read the label when buying a food product for the first time, their propensities to seek food-related information and their perceived levels of exposure to food risks have enabled us to define Italian consumers’ attitudes towards food risks. Distinguishing between consumers with more self-protective attitudes and those with less self-protective attitudes and identifying their distinctive socio-demographic and behavioural characteristics (e.g. gender, age, the frequency with which respondents do grocery shopping and the channels used for further inquiry) are crucial for communication campaigns aimed at reducing consumers’ exposure to food risks. [ABSTRACT FROM PUBLISHER]

• First survey in Italy to describe the prevalence of nausea and vomiting in pregnancy. • Results show high prevalence of nausea and vomiting in pregnancy. • A high percentage of pregnant women took medications for nausea and vomiting. • Symptoms had a negative influence on daily activities and social relationships. • Data underline the need for recognition of this neglected maternal disease. • Screening for nausea and vomiting should be offered during pregnancy. Nausea and vomiting in pregnancy is a common and invalidating condition in early pregnancy. However, no data are available on its prevalence in Italy. This survey aims to evaluate the prevalence and impact of nausea and vomiting during pregnancy on the quality of life of Italian women. The survey was performed in three Italian public University Hospitals in two distinct periods: a first interview took place between the 18th and 22nd week of pregnancy, using the Questionnaire for Pregnancy Period (14 questions regarding demographic data and 30 questions about nausea and vomiting in pregnancy, including Pregnancy-Unique Quantification of Emesis questionnaire), and a follow-up interview, by telephone call, took place immediately after giving birth and in any case within 14 days of delivery, using the Questionnaire for Post-Pregnancy (9 questions). Included women were Caucasian, in physiological pregnancy and between the 18th and 22nd week (time of morphological ultrasound), able to communicate adequately with the interviewer, understand the questionnaires and able to provide valid informed consent. Twin pregnancies and women who recurred to medically assisted procreation were excluded. This is an interim report on data collected from 232 of the planned 600 women. Mean age of the recruited subjects was 32.6 ± 4.6 years, with approximately 60% primiparous. The prevalence of nausea and vomiting in pregnancy in the sample examined was 65.5% overall (152 out of 232 subjects). Of these 152 women, 63 (41.4%) experienced only nausea, 6 (3.9%) only vomiting, and 83 (54.6%) reported both. Symptoms were reported to begin at 7.2 ± 2.7 weeks, lasted 10.2 ± 5.6 weeks, and persisted at the time of the interview in 32.2% of cases. Overall, over 50% of the women interviewed experienced a negative impact of nausea and vomiting in pregnancy on social relationships and work activity. A high prevalence of nausea and vomiting in pregnancy, 65.5% overall, was found in this interim analysis. These symptoms appeared capable of negatively influencing women quality of life. Screening procedures should be offered during pregnancy and measures that address nausea and vomiting in pregnancy impact warranted. [ABSTRACT FROM AUTHOR]

In this paper, we investigate the impact of climate change on coastal sediment transport in a deltaic system in the northern Adriatic Sea, with reference to the period 2070-2099 in the IPCC A1B emission scenario. Wind fields obtained by means of the high-resolution regional climate model Consortium for Small-scale Modelling-Climate Limited-area Modelling were employed for computing wave climate at basin scale by means of the spectral wave model Simulating Waves Nearshore. This was used as a constraint for a nearshore hydromorphodynamic model (MIKE LITPACK), which was applied to a test site on the Po River Delta, located in northern Italy. Relevant sediment transport processes have been studied at storm and decadal time scales in order to capture climate change effects on single events and as an overall trend. The transport rates in the A1B climate change scenario were then compared with the corresponding results of a control analysis (period 1965-1994) representing the actual climate. Although predicted wave climate in the investigated scenario displays an overall decrease in sea severity offshore in the northern Adriatic Sea, the effects of these modifications are modulated during the onshore propagation, with different impacts on sediment transport depending on the considered process and time scale. The strategy presented in this work can find fruitful applications in the long-term modelling of coastal and transitional environments, in which morphology is strongly influenced by sediment transport in the nearshore zone, suggesting a methodological approach for coastal planning and management. [ABSTRACT FROM AUTHOR]

Objectives The aim was to compare the efficacy of the electric versus the manual toothbrush in terms of the oral hygiene achieved by patients wearing rapid palatal expanders ( RPEs). Methods Forty patients were randomly divided into two groups; one equipped with a manual toothbrush (Group A), the other with an electric toothbrush (Group B). Each child's plaque index ( PI) and gingival index ( GI) were calculated at banded molar level at times T0 (before banding), T1 (a month later), T2 (3 months later) and T3 (when the expander was removed). At each appointment, the PI and GI were recorded and the patient was remotivated. Results The level of oral hygiene achieved by the group using an electric toothbrush produced a greater improvement in the two indexes than in the group using the manual toothbrush that showed no statistically significant improvement ( PI T0-T3: P = 0.309; GI T0-T3: P = 0.141). Both indexes dropped considerably in both groups from T0 to T2, but more so in the group B. From T2 to T3, although the electric toothbrush continued to be substantially more effective, Group B showed a statistically significant deterioration in the oral hygiene ( PI +20%; GI +33%). Other assessments conducted on particular areas of the tooth showed improvements in the PI (−33%) for the vestibular region, and for the GI (−57%) in the palatal region among the patients in Group B, while there were no significant changes in these indexes in Group A. Conclusions Our findings show that the electric toothbrush is statistically more efficient in performing an adequate level of oral hygiene in children wearing RPE. [ABSTRACT FROM AUTHOR]

Aim: A retrospective survey was performed to identify factors predicting functional recovery in an elderly population admitted to a subacute care nursing home for rehabilitation treatment (abbreviated RSA. from the Italian: "Residenza Sanitaria Assistenziale"). Methods: Demographic data (age and sex), clinical features (type of disease at admission, length of stay in RSA, Barthel Index (Bl) at admission and discharge, duration of rehabilitation treatment and destination at discharge) were extracted from the medical records of 551 subjects. Multiple logistic regression was used to assess relationships between functional outcome on the Bl and predictive variables. Results: Of all subjects, 239 (43.3%) had neurological, 214 (38.8%) orthopaedic and 98 (17.7%) internal disorders. On discharge from the RSA, subjects with orthopedic and internal diseases showed significantly greater functional improvement than those with neurological disorders (p<0.0001). Multivariate analysis showed that the independent variables related to functional recovery on the Bl were pathology (orthopedic and internal diseases), Bl (≤32) score at RSA admission, and duration of rehabilitation treatment (≥30 sessions). Conclusion: Our results may help to optimize management of older adults admitted to an RSA for rehabilitation treatment. [ABSTRACT FROM AUTHOR]

Aim: To estimate occurrence of non-specific musculoskeletal pain in a wide population sample of Italian adolescents, and to investigate their use of healthcare services (seeking of medical attention, referral for diagnostic tests and treatment use). Methods: We investigated 7542 high-school adolescents (aged between 12 and 16 years) by a structured questionnaire and consisting of personal data, presence of pain, health provider consulted, referral for diagnostic tests and compliance with the prescribed treatments. Results: In 3399 (45.1%) reported musculoskeletal pain (the most affected sites being the spine and knees), 2525 (74.2%) of whom had sought medical attention. Of the 2525 subjects who had sought healthcare, 1061 (42.0%) had consulted more than one health provider, 2410 (95.4%) had been referred for diagnostic tests, and some form of treatment had been recommended for 2445 (96.8%), but only 1694 (69.2%) had complied with prescribed therapies. The most important factors linked to health seeking behaviour were pain intensity, pain lasting longer than 3 months, injury, interruption to or absence of physical activity and localization in the spine and knee. Conclusion: Non-specific musculoskeletal pain is a frequent event in Italian adolescents and that a large number of these subjects consult a healthcare service. [ABSTRACT FROM AUTHOR]

Abstract: This model is based on the concept of transport concentration, defined as the time-averaged concentration in a given location of a lagoon, which determines the long-term net transport of sediments as the sum of a dispersive and an advective flux. Dispersive net flux of sediments is due to the alternate components of the tidal flow, while the advective net flux of sediments is due to the residual (Eulerian) component of the tidal, fluvial and littoral flow and possibly to the asymmetry between flow and ebb tide. The long-term deposition (or erosion) rate in a given location is expressed as proportional to the difference between the local transport concentration and the local equilibrium concentration, depending in turn on the local stirring action by waves and currents. The two-dimensional model is able to reproduce the ontogeny of a tidal lagoon as a consequence of a breaching of the littoral dune line. During the ontogenetic phase, the system tends rapidly toward a quasi-equilibrium condition apparently characterized by a stable planimetric configuration of the channel network. The structure of the channels and their watersheds is qualitatively similar to the Venice Lagoon''s ones. After the relatively fast ontogenetic phase, the subsequent morphological evolution of the bottom continues at a slower pace until a stable bathymetric configuration of the lagoon is reached. The model is able to reproduce the morphological effects of subsequent perturbations of natural or anthropogenic origin. [Copyright &y& Elsevier]