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X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception, single-crystal cryocrystallography has never been performed in Türkiye due to the lack of a single-crystal X-ray diffractometer. The X-ray diffraction facility recently established at the University of Health Sciences, İstanbul, Türkiye will enable Turkish and international researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the technical and practical outlook of a state-of-the-art home-source X-ray, using lysozyme as a model protein. The methods and practice described in this article can be applied to any biological sample for structural studies. Therefore, this article will be a valuable practical guide from sample preparation to data analysis. [ABSTRACT FROM AUTHOR]

Halit Ziya (Uşaklıgil) explained his thoughts on Tanzimat literature in his work named, “Kırk Yıl” in which he wrote his literary memoirs. One of main elements that draw attention in the work is the author’s observations and opinions about the literary circles he visited here, after he went from Izmir to Istanbul. The author gathered those who worked on the path of classical literature under the roof of Muallim Naci School and those who worked on the path to new litrature under the roof of Namık Kemal School. Muallim Naci evaluated and his environment from a negative point of view. He stated that the writers belonging to this school produced Works within the framework of Divan literature. He accused the Muallim Naci School of having a narrow World view, which was devoted to the past. H eapproached Ebuzziya Tevfik, Recaizade Mahmut Ekrem and Samipaşazade Sezai with a positive perspective and praised these authors for giving Works within the framework of new literature. He depicted Ebuzziya Tevfik as kind and gentleman. He highlighted Recaizade Mahmut Ekrem in terms of lifestyle, wordview and literary criticism. Halit Ziya drew attention to the fact that Sami Paşazade Sezai is a powerful pen in prose. [ABSTRACT FROM AUTHOR]