1. Effect of early nephrology referral on the mortality of dialysis patients in Israel.
- Author
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Yanay NB, Scherbakov L, Sachs D, Peleg N, Slovodkin Y, and Gershkovich R
- Subjects
- Aged, Delayed Diagnosis, Female, Humans, Israel epidemiology, Male, Outcome Assessment, Health Care, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis, Time Factors, Nephrology methods, Referral and Consultation statistics & numerical data, Renal Dialysis methods, Renal Dialysis statistics & numerical data, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic mortality, Renal Insufficiency, Chronic therapy
- Abstract
Background: Late nephrology referral, before initiation of dialysis treatment, is associated with adverse outcome., Objectives: To investigate the implications of late nephrology referral on mortality among dialysis patients in Israel., Methods: We retrospectively analyzed 200 incident dialysis patients. Patients were defined as late referrals if they started dialysis less than 3 months after their first nephrology consultation. Survival rates and risk factors for mortality were analyzed, Results: The early referral (ER) group comprised 118 patients (59%) and the late referral (LR) group 82 patients (41%). The mortality rate was 44.5% (53 patients) in the ER and 68% (n = 56) in the LR group. The 4 year survival rate was 41.1% in the ER and 18.7% in the LR group (P < 0.0001). The mortality rate increased with late nephrology referral (HR 1.873, 95% CI 1.133-3.094), with age (HR 1.043 for each year, 95% CI 1.018-1.068), with diabetes (HR 2.399, CI 1.369-4.202), and with serum albumin level (HR 0.359 for an increase of each 1 g/dl, 95% CI 0.242-0.533). The median survival time was higher for the ER group in women, in patients younger than 70, and in diabetic patients. A trend for longer survival time was found in non-diabetic patients. Survival time was not increased in early referred patients older than 70 and in male patients., Conclusions: Late nephrology referral is associated with an overall higher mortality rate in dialysis patients. The survival advantage of early referral may have a different significance in specific subgroups. The timing of nephrology referral should be considered as a modifiable risk factor for mortality in patients with end-stage renal disease.
- Published
- 2014