1. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches.
- Author
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Ryan S, Cummins EP, Farre R, Gileles-Hillel A, Jun JC, Oster H, Pepin JL, Ray DW, Reutrakul S, Sanchez-de-la-Torre M, Tamisier R, and Almendros I
- Subjects
- Humans, Ireland, Precision Medicine, Sleep, Cardiovascular Diseases therapy, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive therapy
- Abstract
In January 2019, a European Respiratory Society research seminar entitled "Targeting the detrimental effects of sleep disturbances and disorders" was held in Dublin, Ireland. It provided the opportunity to critically review the current evidence of pathophysiological responses of sleep disturbances, such as sleep deprivation, sleep fragmentation or circadian misalignment and of abnormalities in physiological gases such as oxygen and carbon dioxide, which occur frequently in respiratory conditions during sleep. A specific emphasis of the seminar was placed on the evaluation of the current state of knowledge of the pathophysiology of cardiovascular and metabolic diseases in obstructive sleep apnoea (OSA). Identification of the detailed mechanisms of these processes is of major importance to the field and this seminar offered an ideal platform to exchange knowledge, and to discuss pitfalls of current models and the design of future collaborative studies. In addition, we debated the limitations of current treatment strategies for cardiometabolic complications in OSA and discussed potentially valuable alternative approaches., Competing Interests: Conflict of interest: S. Ryan has nothing to disclose. Conflict of interest: E.P. Cummins has nothing to disclose. Conflict of interest: R. Farre has nothing to disclose. Conflict of interest: A. Gileles-Hillel has nothing to disclose. Conflict of interest: J.C. Jun has nothing to disclose. Conflict of interest: H. Oster has nothing to disclose. Conflict of interest: J-L. Pepin has nothing to disclose. Conflict of interest: D.W. Ray has nothing to disclose. Conflict of interest: S. Reutrakul reports grants from Merck Sharp and Dohme, personal fees from Medtronic and Sanofi Aventis, outside the submitted work. Conflict of interest: M. Sanchez-de-la-Torre has nothing to disclose. Conflict of interest: R. Tamisier reports travel grants from Agiradom, grants from Resmed, personal fees for lectures from Resmed, Philips and Elivie, personal fees for consultancy from Navigant, Inspire, Jazz Pharmaceutical and Resmed, outside the submitted work. Conflict of interest: I. Isaac Almendros has nothing to disclose., (Copyright ©ERS 2020.)
- Published
- 2020
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