1. Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder.
- Author
-
Weizmann R, Gur E, Laor N, Reiss A, Muller U, Yoresh A, Lerer B, and Newman ME
- Subjects
- Adult, Aged, Cell Membrane enzymology, Colforsin antagonists & inhibitors, Colforsin pharmacology, Epinephrine pharmacology, Female, Humans, Iraq, Israel, Male, Middle Aged, Psychiatric Status Rating Scales, Sodium Fluoride pharmacology, Stimulation, Chemical, Stress Disorders, Post-Traumatic blood, Warfare, Adenylyl Cyclases blood, Blood Platelets enzymology, Stress Disorders, Post-Traumatic enzymology
- Abstract
Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha 2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a-like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.
- Published
- 1994
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