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Background and Objectives: In the past few decades, spiritual health, as one of the dimensions of health besides physical, mental, and social health, has drawn the attention of psychologists and mental health professionals more than ever. However, there is a research gap in our country, so the primary purpose of this study was to investigate the relationship between spiritual health and school burnout with the mediating role of social support. Methods: This descriptive correlational research used the path analysis method. The statistical population comprised all sixth-grade female students (600 people) in Rudbar City, Iran, in the academic year 2020-2021. The sample size is calculated with the Morgan table (234 people). The samples were recruited by a simple random sampling method, and the research tools were the related questionnaire. The content validity and reliability of this research were confirmed. The tests were analyzed according to the research questions by path analysis, the Pearson correlation coefficient, and the 1-sample t test. The obtained data were analyzed in SPSS v. 26 software and LISREL software v. 8.8. Results: There is a significant relationship between spiritual health and school burnout (P=0.01). Also, there is a significant relationship between spiritual health and social support (P=0.01). The t values obtained from the studied paths have P-values less than 0.05, so the indirect effects were statistically significant. So, social support has had an indirect impact on spiritual health and academic burnout. Conclusion: One of the influential factors in reducing school burnout and increasing spiritual health is the social support perceived by students. [ABSTRACT FROM AUTHOR]