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Background: The aim of the current study is to assess the prevalence of different categories of thyroid dysfunction and their associated risk factors among the modern urban population of Tehran, the capital of Iran., Methods: The present investigation is a sub-study of the HAMRAH study, a population-based prospective study designed to assess the prevalence of traditional cardiovascular risk factors and their changes through a 10-year follow-up. 2228 (61% female) adults aged between 30 and 75 years old and with no overt cardiovascular diseases were selected through a multistage cluster randomized sampling. Blood levels of thyroid-stimulating hormone (TSH), thyroxin (T4), and triiodothyronine (T3) were measured with the aim of assessing the prevalence of abnormal thyroid function status among the modern urban Iranian population, and in order to report the total prevalence of participants with clinical hypo- or hyperthyroidism, the number of individuals taking thyroid-related drugs were added to the ones with overt thyroid dysfunction. A subgroup analysis was also performed to determine the associated risk factors of thyroid dysfunction., Results: The prevalence of thyroid dysfunction among the total population was 7% (95%CI: 5.9 - 8%) and 0.4% (95% CI: 0.1 - 0.6%) for subclinical and overt hypothyroidism, and 1.6% (95% CI: 1 - 2%) and 0.2% (95% CI: 0 - 0.3%) for subclinical and overt hyperthyroidism, respectively. Clinical thyroid dysfunction was detected in 10.3% of the study population (9.4% had clinical hypo- and 0.9% had clinical hyperthyroidism). In the subgroup analysis, thyroid dysfunction was significantly more prevalent among the female participants (P-value = 0.029)., Conclusions: In the current study, the prevalence of different categories of abnormal thyroid status, and also the rate of clinical hypo- and hyperthyroidism was assessed using the data collected from the first phase of the HAMRAH Study. In this study, we detected a higher prevalence of clinical and subclinical hypothyroidism among the Iranian population compared to the previous studies., (© 2023. The Author(s).)

Cysteine-Rich Secretory Protein 2 (CRISP2) plays an important role in the morphology and motion of male ejaculated spermatozoa. The association of its expression with some miRNAs is also well known. The aim of this study was to determine the expression of CRISP2 and mir-582 in the seminal plasma fluid and spermatozoa of three groups of infertile men and the possible association of their expressions. In this experimental study, the expression of CRISP2 in seminal plasma fluid and spermatozoa of 17 men with asthenozoospermia, 15 men with teratozoospermia, 17 men with teratoasthenozoospermia, and 18 infertile individuals with normozoospermia were measured using western blotting. Then by using bioinformatics studies, miR-582-5p was nominated as a CRISP2-associated miRNA, and its expression was evaluated by means of Real-Time PCR. Comparison of expression of CRISP2 and miRNA-582 in the studied groups was analyzed by t-test and Mann-Whitney U test. The expression of CRISP2 showed a significant reduction in the spermatozoa and seminal plasma fluid of all three groups, (p < 0.05). MiR-582-5p expression significantly increased in teratozoospermia patients (<0.05), and significantly decreased in teratoasthenozoospermia patients (p < 0.05). Meanwhile, changes in the expression of miR-582-5p in teratoasthenozoospermia individuals was associated with a decrease in the expression of CRISP2, which could represent the potential role of miR-582-5p in regulation of CRISP2 expression in teratoasthenozoospermia individuals., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Coastal vulnerability assessment has become one of the most important tools for decision making and providing effective managerial solutions to reduce adverse socio-economic impacts of multiple environmental hazards on coupled social-ecological systems of coastal areas. The aim of this study was to assess the vulnerability of the northern coasts of the Persian Gulf (PG) and the Gulf of Oman (GO) in the Hormozgan province of Iran. Nine variables of vulnerability that included the rate of coastline change, relative sea level rise, coastal slope, mean tidal range, coastal geomorphology, significant wave height (SWH), extreme storm surge, population density, and fishing intensity were weighted, mapped, and combined into the Coastal vulnerability index (CVI). Experts viewed sea level rise, shoreline change and extreme storm surge as most important for imparting vulnerabilities on the northern coasts of PG and GO. Socio-economic variables (i.e., population density and fishery intensity) were considered least important. Of the total length of the provincial shoreline, 27% were classified into the very low vulnerability class, 31% into the low, 17.4% into the moderate, 15.4% into the high, and 9.2% into the very high vulnerability class. About 1295 km (58%) of shorelines were classified into the low and very low vulnerability classes (CVI value ≤ 8.32) and mainly consisted of shorelines on the western coast along the PG. In contrast, 553 km (24.6%) of shorelines were classified into the high and very high vulnerability classes (CVI values > 13.39) and were located along the central coasts (especially in the Qeshm Island and Strait of Hormuz) and on the east coasts of the GO. At least a quarter of all shorelines in the province have high and very high vulnerability to environmental hazards that are the harbingers of climate change., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Leaf Area Index (LAI; as an indicator of the health) of the mangrove ecosystems on the northern coasts of the Persian Gulf and the Gulf of Oman was measured in the field and modeled in response to observed (1986-2017) and predicted (2018-2100) drought occurrences (quantified using the Standardized Precipitation Index [SPI]). The relationship of LAI with the normalized difference vegetation index (NDVI) obtained from satellite images was quantified, the LAI between 1986 and 2017 retrospectively estimated, and a relationship between LAI and SPI developed for the same period. Long-term climate data were used as input in the RCP8.5 climate change scenario to reconstruct recent and forecast future drought intensities. Both the NDVI and the SPI were strongly related with the LAI, indicating that realistic LAI values were derived from historic satellite data to portray annual changes of LAI in response to changes in SPI. Our findings show that projected future drought intensities modeled by the RCP8.5 scenario increase more and future LAIs decreased more on the coasts of the Gulf of Oman than the coasts of the Persian Gulf in the coming decades. The year 1998 was the most significant change-point for mean annual rainfall amounts and drought occurrences as well as for LAIs and at no time between 1998 and 2017 or between 2018 and 2100 are SPI and LAI values expected to return to pre-1998 values. LAI and SPI are projected to decline sharply around 2030, reach their lowest levels between 2040 and 2070, and increase and stabilize during the late decades of the 21st century at values similar to the present time. Overall, this study provides a comprehensive picture of the responses of mangroves to fluctuating future drought conditions, facilitating the development of management plans for these vulnerable habitats in the face of future climate change., (Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.)