1. Association between Thyroid Function and Body Mass Index: A 10-Year Follow-Up.
- Author
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abdi, Hengameh, Kazemian, Elham, Gharibzadeh, Safoora, amouzegar, atieh, Mehran, Ladan, Tohidi, Maryam, Rashvandi, Zahra, and azizi, Fereidoun
- Subjects
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BODY weight , *CONFIDENCE intervals , *LONGITUDINAL method , *OBESITY , *POISSON distribution , *THYROID diseases , *THYROID gland function tests , *THYROTROPIN , *THYROXINE , *LOGISTIC regression analysis , *BODY mass index , *RELATIVE medical risk , *DESCRIPTIVE statistics - Abstract
Background/Aims: We aimed to evaluate the association between change in thyroid function tests within the euthyroid range and body mass index (BMI) in persons with normal weight at baseline. Methods: This study investigated 1,100 normal-weight euthyroid persons in a population-based cohort study, Tehran Thyroid Study. BMI was calculated and serum concentrations of thyrotropin (TSH) and free T4 (FT4) were assayed at baseline and after 10 years of follow-up. We evaluated the relationship between thyroid and obesity based on 2 definitions for outcome: (1) a binary outcome as BMI <25 or ≥ 25 kg/m2, and (2) a multinomial outcome as normal BMI, overweight, and obese. Results: A total of 569 women and 531 men, aged 36.3 ± 13.5 years, were included. Modified Poisson regression analysis for binary outcome, after adjustment for age, sex, smoking, and antithyroid peroxidase antibody status, revealed a negative association between delta serum FT4 and follow-up BMI (relative risk 0.55 [95% CI 0.37–0.80]) without any significant association between change in serum TSH and follow-up BMI. However, in multinomial logistic regression analysis, we found no relationship between delta serum FT4 or TSH and follow-up BMI categories, for either overweight or obese vs. normal-weight participants. Conclusions: In normal-weight euthyroid individuals, changes in serum concentrations of FT4, but not TSH, may contribute to change in body weight. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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