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Drought is one of the most common natural phenomena. Many indices using multiple data types have been created, and their success at recognizing periods of extreme wetness and dryness has been well documented. The merit of the method is the utilization of terrestrial water storage (TWS) variations from Gravity Recovery and Climate Experiment (GRACE) quantification of drought intensity. Alongside with these observations, we add precipitation data to equations. In this study, we analyze Merged-dataset Drought index (MDI) using GRACE-derived TWSA and precipitation in Iran, where most of the area is desert and mountain in the middle and South of the country. Our sample period is from January 2003 to December 2014. MDI shows a strong correlation with existing drought indices, especially with the Palmer Drought Severity Index (PDSI). Based on the obtained results, MDI indicates a moderate Drought event in 2008 and 2012–2015, which is compatible with the recorded result of PDSI. The longest drought took 22 months (from January 2008 to October 2009). Interestingly, the coefficient of correlation between MDI and PDSI is 0.67. [ABSTRACT FROM AUTHOR]

Introduction: Tuberculosis (TB) remains a serious public health problem worldwide. Drug-resistant TB is considered a major and growing global threat. Despite the great variety of described mutations in Mycobacterium tuberculosis (MTB) resistance genes, the mechanisms of drug resistance are still controversial. Recently, a report on the role of efflux pump genes in drug resistance added to this complexity. Therefore, a thorough understanding of efflux pump genes in drug-resistant TB clinical isolates is needed., Methodology: We performed molecular analysis of the efflux pump gene (Rv1258c) in 33 drug-resistant and 20 drug-sensitive clinical MTB isolates by sequencing the amplicons' targets in both the forward and reverse directions., Results: A novel mutation of the Rv1258c gene was identified at G442A (Ala148Thr) in rifampicin mono-resistant clinical strain, as compared to the H37Rv reference strain. In addition, a cytosine nucleotide insertion was found between the positions 580 and 581 (denominated Tap580) in two drug-sensitive strains at identical gene positions., Conclusions: These results indicated the possibility of mutation in the efflux pump genes and the important role of Tap efflux pump genes in drug-resistant MTB isolates. However, further research is required to determine the direct association of these mutations with resistant MTB., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2024 ShimaSadat Farzaneh, Fatemeh Norouzi, Hossein Fazeli, Mahshid Salehi, Marzieh Safari, Bahram Nasr Esfahani.)

Vitiligo is a pigmentary disorder resulting from progressive destruction of melanocytes in the skin. There is a growing body of evidence about higher risk of metabolic syndrome and dyslipidemia in some dermatoses including vitiligo. We aimed to evaluate lipid profile, leptin and C reactive protein (CRP) status among Iranian patients with vitiligo, compared with healthy controls and perused the relationship between abnormal values of these parameters with disease duration and physical characteristics of patients. 40 patients with vitiligo and 40 age-matched and sex-matched healthy controls were enrolled in the study. Data on weight, height, lipid profile, leptin and CRP values were recorded and compared. The mean values for nearly all study parameters (except for high-density lipoprotein) were significantly higher in patients with vitiligo, compared with healthy controls, irrespective of age and sex. We could not find any correlation between vitiligo and study parameters, regarding disease severity and extension of lesions; but in patients who have been suffering from vitiligo for more than 5 years, systolic blood pressure, diastolic blood pressure and CRP values were noted to be significantly higher (p<0.001, p=0.003 and p=0.03, respectively). In conclusion, screening of patients with vitiligo in regard to their lipid profile as well as blood pressure should be considered, especially in patients with longer disease duration or those who have other cardiovascular risk factors to prevent morbidity and mortality as a result of developing cardiovascular events., Competing Interests: Competing interests: None declared., (© American Federation for Medical Research 2022. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.)