1. Celiac disease and Hp infection association in Iran.
- Author
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Rostami-Nejad M, Villanacci V, Mashayakhi R, Molaei M, Bassotti G, Zojaji H, Mirstatari D, Rostami K, and Zali MR
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Celiac Disease diagnosis, Celiac Disease epidemiology, Celiac Disease pathology, Duodenum pathology, Enzyme-Linked Immunosorbent Assay, Female, Helicobacter Infections diagnosis, Helicobacter Infections epidemiology, Helicobacter Infections pathology, Humans, Iran, Male, Middle Aged, Prevalence, Serology, Stomach pathology, Celiac Disease complications, Helicobacter Infections complications, Helicobacter pylori
- Abstract
Background: we assessed the prevalence, the related symptoms, and the endoscopic and histologic gastric features of celiac disease (CD) in patients with Helicobacter pylori (Hp)., Methods: 450 dyspeptic patients were studied. Biopsies of gastric antrum and duodenum, CD serology, and total IgA were obtained. Histological findings were scored with the Marsh-Rostami criteria., Results: 411 (91.3%) patients were Hp positive. Duodenal histology was normal in 385 (85.6%) patients, 124 (27.5%) had duodenitis and 28 (6.2%) showed duodenal abnormalities (Marsh I-IIIc). Twenty three/28 (82.1%) patients with malabsorption pattern were also Hp positive. Serological analysis: 12 of 31 (38.7%) positive patients had abnormal histology (Marsh I,-IIIc). Nine out 450 patients were IgA deficient; none of them was serologically positive for CD., Conclusion: although a high prevalence of Hp infection was found in this study, the relationship between Hp infection and CD was similar to that reported in other geographic areas.
- Published
- 2009
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