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The main route of fluoride uptake is drinking water. Fluoride absorption in the acceptable range (0.5–1.5 mg L−1) is suitable for the body, but its too much consumption can have irreversible health effects. To compare fluoride concentration with the WHO guidelines, 112 water samples were taken from groundwater aquifers in 22 villages of Garmsar County, the central part of Iran, during 2018 to 2019. Fluoride concentration was measured by the SPANDS method and its non-carcinogenic impacts were calculated using EDI and HQ. The statistical population was divided into four categories of infant, children, teenagers, and adults. Linear regression and Spearman rank correlation coefficient tests were used to investigate the relationships between the well's depth and fluoride concentration in the water samples. The annual mean concentrations of fluoride in 2018 and 2019 were 0.75 and 0.64 mg L−1and, the fluoride mean concentration in the samples classifying the cold and hot seasons of the studied years was 0.709 and 0.689 mg L−1, respectively. The amount of fluoride in 27% of the samples in both years was less than the acceptable minimum (0.5 mg L−1). Also, 11% of the samples in 2018 (6 samples) had fluoride levels higher than 1.5 mg L−1. The HQ showed that the children were vulnerable; teenagers and adults were in the next ranks, respectively. Statistical tests showed a reverse and significant correlation (R2 = – 0.02, β < 0.0001) between well depth and fluoride content. The border between the usefulness/harmfulness of fluoride is very narrow and requires extensive studies. [ABSTRACT FROM AUTHOR]

The consumption of bottled water has witnessed substantial global expansion in recent times. This study aimed to quantitatively evaluate the concentrations of eight heavy metals (As, Ba, Cd, Cr, Mn, Mo, Ni, and Zn) in 71 high-consumption bottled water brands in Iran. Non-carcinogenic and carcinogenic risk assessments were conducted using both deterministic and probabilistic approaches. Point estimation utilizing the Hazard Quotient (HQ) formula and sensitivity analysis employing the Monte Carlo Simulation (MCS) method through 10,000 repetitions in Oracle Crystal Ball® was used to ascertain the health risks associated with heavy metal exposure. Heavy metal concentrations were quantified through Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES). HQ point estimation results indicated that Cr exhibited the highest mean HQ value, whereas Cd demonstrated the lowest. In the probabilistic approach, the highest 95 percentile values were observed for Cr and Mo at 3.9E-01, while the lowest values were recorded for Cr and Mn at 1.10E-02. Heavy metal concentrations emerged as critical factors influencing non-carcinogenic and carcinogenic risks across all groups in the sensitivity analysis. The findings highlight the need for ongoing monitoring, research, and targeted regulations to address health risks from heavy metal exposure in bottled water and ensure public well-being. • Comprehensive health risk assessment of 8 heavy metals in high-consumption bottled water in Iran. • Utilization of deterministic and probabilistic approaches for non-carcinogenic and carcinogenic risk assessment. • Sensitivity Analysis (SA) identified key factors influencing non-carcinogenic and carcinogenic risks. • Using ArcGIS and IDW interpolation for spatial analysis in local health risk management. • Findings urge ongoing study and rules to manage health risks from heavy metals in bottled water. [ABSTRACT FROM AUTHOR]