1. Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls.
- Author
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TAHERY, Noorollah, REZAEI TAVIRANI, Mostafa, ZAMANIAN AZODI, Mona, HAMDIEH, Mostafa, ROSTAMI NEJAD, Mohammad, and MAHMOODI, Nahid
- Subjects
BLOOD serum analysis ,DIAGNOSIS of obsessive-compulsive disorder ,DIAGNOSIS of bipolar disorder ,PROTEINS ,BIOMARKERS ,BLOOD proteins ,ELECTROPHORESIS ,PROTEOMICS ,VITAMIN D ,COMPARATIVE studies ,PSYCHOLOGY of women ,MASS spectrometry ,DESCRIPTIVE statistics ,GLOBULINS ,OBSESSIVE-compulsive disorder ,BIPOLAR disorder ,CARRIER proteins - Abstract
Objectives The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. Materials & Methods Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. Results The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. Conclusion The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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