1. HLA and elephantiasis revisited.
- Author
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Yazdanbakhsh M, Abadi K, de Roo M, van Wouwe L, Denham D, Medeiros F, Verduijn W, Schreuder GM, Schipper R, Giphart MJ, and de Vries RR
- Subjects
- Animals, Brugia, Case-Control Studies, HLA-DQ Antigens genetics, HLA-DR Antigens genetics, Humans, Indonesia, Middle Aged, Alleles, Elephantiasis, Filarial genetics, Genes, MHC Class II genetics
- Abstract
A recent case-control study in Indonesia suggested that the course of Brugian filariasis and in particular resistance to the development of elephantiasis was associated with certain HLA class II alleles. In order to see whether these data could be confirmed we conducted a similar study in another Indonesian population from South Sulawesi. We could not confirm our earlier results and therefore concluded that HLA-DR and -DQ alleles are at least not strongly associated with progression to elephantiasis in Brugian filariasis. The complete data are presented also for anthropological reference purposes.
- Published
- 1997
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