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Introduction: Diarrhea is a global problem that commonly occurs in cases of gastrointestinal infection. The prevalence of diarrhea in Indonesia was 6.8% according to Riskesdas 2018 data. The conventional diagnosis in cases of gastrointestinal infection is limited in sensitivity and time. This may be overcome by gastrointestinal syndromic testing that can detect a number of pathogens simultaneously in one assay. The aim of this study was to determine the role of the gastrointestinal syndromic testing panel in patients with gastrointestinal infection. Methodology: This retrospective study of stool specimens performed syndromic testing and microbiological cultures at a private hospital in Central Jakarta. Results: Of the 119 specimens with negative culture test results, syndromic gastrointestinal testing found pathogens in 46 specimens (38.7%), of which 32 specimens contained a single pathogen and 14 specimens had > 1 pathogen. The most frequently found pathogens were enteropathogenic E. coli, enteroaggregative E. coli, and C. difficile A/B toxins. Conclusions: Syndromic testing can increase the etiologic diagnosis of gastrointestinal infections in a shorter time period than the conventional methods. [ABSTRACT FROM AUTHOR]

Introduction: The prevalence of metabolic syndrome (MetS) in Indonesia is 39% and it is higher in females than in males (46% vs. 28%). Features of this syndrome comprise low-grade chronic inflammation and endothelial dysfunction from cardiometabolic abnormalities. High-sensitive C-reactive protein (HsCRP) is a biomarker of cardiovascular disease, whereas ferritin and pentraxin-3 (PTX-3) are markers of chronic inflammation. One of the markers of endothelial dysfunction is an intercellular cell adhesion molecule-1 (ICAM-1). Studies on MetS in women aged 50-70 years and using several markers of inflammation and endothelial dysfunction are rare. The study aimed to determine differences in HsCRP, ferritin, PTX-3, and ICAM-1 level between females with and without MetS aged 50-75 years. Methods: For this cross-sectional study, 160 females aged 50-75 years from South Jakarta were recruited, divided into MetS and non-MetS (control) groups, 80 participants each. Participants that met the inclusion criteria were assessed for vital signs and metabolic parameters (e.g., lipid profile, fasting blood glucose level, and waist circumference [WC]). The groups were compared using an independent t-test for inflammatory (i.e., HsCRP, PTX-3, and ferritin) and endothelial dysfunction (ICAM-1) (p < 0.05) biomarkers. Results: The mean age of the MetS and control groups was 59.6 ± 5.6 and 59.2 ± 5.5 years. MetS criteria included WC of ≥80 cm (95.2%), increased blood pressure level (90.6%); and high-density lipoprotein cholesterol of <50 mg/dL (76.2%). Significant differences were found between the MetS and control groups for ferritin (p = 0.027), PTX-3 (p = 0.045), and ICAM-1 (p = 0.004) but not for HsCRP (p = 0.136). Conclusion: Elevated ferritin, PTX-3 level, and ICAM-1 level are significantly associated with an increased Mets risk in females aged 50-75 years; however, the same is not true for HsCRP. [ABSTRACT FROM AUTHOR]

As more ambitious protected area (PA) targets for the post-2020 global biodiversity framework are set beyond Aichi Target 11, renew thinking into spatial prioritisation is required to enable PA expansion that maximises environmental values. Our study focuses on the biodiverse and forest-rich Indonesian island of Sulawesi, which has a terrestrial PA network that covers 10% of the island. We used Marxan to investigate trade-offs in the design of an expanded PA network that prioritised different conservation features (biodiversity, forest cover, carbon stock, karst and valuable metal-rich areas) under varying island-wide coverage targets (17%, 30%, and 50%). Our first scenario, which required existing PAs to be selected, required larger areas to meet these coverage targets, in contrast to our second scenario, which allowed for any part of the island to be chosen, irrespective of PA status. The vast Mekongga and Bangkiriang Landscapes, and Gorontalo corridor were consistently identified as a high priority for protection under all scenarios. To meet our conservation targets through expanding current PAs, creating new PAs, and creating corridors that connect existing PAs, we used a spatially explicit three-phase approach. Our findings identified 26,508 km2 of priority areas to be included in the current PA network, potentially assisting Indonesia in meeting its post-2020 GBF target, if our approach is replicated across Indonesia as a national or sub-national analysis. We discuss various land management options through other effective area-based conservation measures (OECMs) and the costs to deliver this strategy. [ABSTRACT FROM AUTHOR]

Introduction: Spinocerebellar ataxia type-3 (SCA3) is an adult-onset autosomal dominant neurodegenerative disease. It is caused by expanding of CAG repeat in ATXN3 gene that later on would affect brain structures. This brain changes could be evaluated using brain MRI volumetric. However, findings across published brain volumetric studies have been inconsistent. Here, we report MRI brain volumetric analysis in a family of SCA 3 patients, which included pre-symptomatic and symptomatic patients. Methodology: The study included affected and unaffected members from a large six-generation family of SCA 3, genetically confirmed using PolyQ/CAG repeat expansion analysis, Sanger sequencing, and PCR. Clinical evaluation was performed using Scale for the Assessment and Rating of Ataxia (SARA). Subjects' brains were scanned using 3.0-T MRI with a 3D T1 BRAVO sequence. Evaluations were performed by 2 independent neuroradiologists. An automated volumetric analysis was performed using FreeSurfer and CERES (for the cerebellum). Result: We evaluated 7 subjects from this SCA3 family, including 3 subjects with SCA3 and 4 unaffected subjects. The volumetric evaluation revealed smaller brain volumes (p < 0.05) in the corpus callosum, cerebellar volume of lobules I-II, lobule IV, lobule VIIB and lobule IX; and in cerebellar gray matter volume of lobule IV, and VIIIA; in the pathologic/expanded CAG repeat group (SCA3). Conclusion: Brain MRI volumetry of SCA3 subjects showed smaller brain volumes in multiple brain regions including the corpus callosum and gray matter volumes of several cerebellar lobules. [ABSTRACT FROM AUTHOR]

Research Aims - This study aims to highlights the role of innovative work behavior (IWB) in determining task performance. The main antecedents of IWB, namely work autonomy and individual global mindset, are discussed, as well as how these two key factors will detemine the degree of individual innovative behavior. Design/Methodology/Approach - This study uses a cross-sectional design with convenience sampling methods to collect primary data and Structural Equation Modelling (SEM) to test the hypothetical model and analyse the data. Research Findings - As many as 309 points of data were received; following screening and selection protocols, the final dataset consisted of 284 responses from employees in innovation center units of a leading ICT company in Indonesia. Findings of this study indicate a positive effect of work autonomy, individual global mindset, and task performance with regard to the mediating effect of IWB. Theoretical Contribution/Originality - This study contributes in defining the positive effects of work autonomy and individual global mindset on IWB and closing the gap regarding the role of IWB in mediating the effect of work autonomy and individual global mindset upon task performance. Managerial Implications in the Southeast Asian Context: As the local market is no longer sufficient to achieve further growth, competing firms need to enter the international or global market; this can be achieved through improved performance resulting from highly innovative behavior. Research Limitations & Implications - Limitations include the limited response rate due to the work-from-home policy during the pandemic, as well as generalizability issues. The current study invite further exploration in terms of the possibilities to elaborate more antecedents for innovative work behavior. [ABSTRACT FROM AUTHOR]

Large carnivores living in tropical rainforests are under immense pressure from the rapid conversion of their habitat. In response, millions of dollars are spent on conserving these species. However, the cost-effectiveness of such investments is poorly understood and this is largely because the requisite population estimates are difficult to achieve at appropriate spatial scales for these secretive species. Here, we apply a robust detection/non-detection sampling technique to produce the first reliable population metric (occupancy) for a critically endangered large carnivore; the Sumatran tiger (Panthera tigris sumatrae). From 2007-2009, seven landscapes were surveyed through 13,511 km of transects in 394 grid cells (17 x 17 km). Tiger sign was detected in 206 cells, producing a naive estimate of 0.52. However, after controlling for an unequal detection probability (where p = 0.13±0.017; ±S.E.), the estimated tiger occupancy was 0.72±0.048. Whilst the Sumatra-wide survey results gives cause for optimism, a significant negative correlation between occupancy and recent deforestation was found. For example, the Northern Riau landscape had an average deforestation rate of 9.8%/yr and by far the lowest occupancy (0.33±0.055). Our results highlight the key tiger areas in need of protection and have led to one area (Leuser-Ulu Masen) being upgraded as a 'global priority' for wild tiger conservation. However, Sumatra has one of the highest global deforestation rates and the two largest tiger landscapes identified in this study will become highly fragmented if their respective proposed roads networks are approved. Thus, it is vital that the Indonesian government tackles these threats, e.g. through improved land-use planning, if it is to succeed in meeting its ambitious National Tiger Recovery Plan targets of doubling the number of Sumatran tigers by 2022. [ABSTRACT FROM AUTHOR]

In a marine environment that is rapidly changing due to anthropogenic activities and climate change, area-based management tools are often used to mitigate threats and conserve biodiversity. Marine protected areas (MPAs) are amongst the most widespread and recognized marine conservation tools worldwide, however, MPAs alone are inadequate to address the environmental crisis. The promotion of other effective area-based conservation measures (OECMs) under draft Target 3 of the Post-2020 Global Biodiversity Framework, i.e., conserving 30% of marine areas by 2030, holds promise to acknowledge sites and practices occurring beyond MPAs that contribute to conservation. Here, we evaluate the potential recognition of OECMs into Indonesia's national policy framework on marine resource management and provide the first-ever overview of distribution and types of potential marine OECMs in Indonesia, including a review of the existing evidence on conservation effectiveness. We identified > 390 potential marine OECMs, led by government, customary and local communities, or the private sector, towards diverse management objectives, including habitat protection, traditional/customary management, fisheries, tourism, or other purposes. While some evidence exists regarding the conservation effectiveness of these practices, the long-term impacts on biodiversity of all potential marine OECMs in Indonesia are unknown. Many OECM elements have been included in several national policies, yet there are no established mechanisms to identify, recognize and report sites as OECMs in Indonesia. We propose four transformational strategies for future OECM recognition in Indonesia, namely: (i) safeguard customary and traditional communities, (ii) leverage cross-sector and cross-scale collaboration, (iii) focus on delivering outcomes, and (iv) streamline legal frameworks. Our study shows that OECMs have the potential to play a significant role in underpinning marine area-based conservation in Indonesia, including supporting the Government of Indonesia in reaching national and international conservation targets and goals. [Display omitted] • OECMs can be a complementary area-based conservation tool beyond MPAs in Indonesia. • Indonesia has > 390 potential marine OECMs, and many have been implemented for centuries. • OECM recognition in Indonesia will contribute to achieving area-based conservation targets. • OECMs in Indonesia can advance effective, inclusive, and equitable conservation. • Four transformational strategies to recognize OECMs in Indonesia are introduced. [ABSTRACT FROM AUTHOR]

William Laurance and colleagues alert to the dangers of limiting the freedom of conservation science in Indonesia and elsewhwere. [ABSTRACT FROM AUTHOR]

Summary: Destruction of tropical rainforests reduces many unprotected habitats to small fragments of remnant forests within agricultural matrices. To date, these remnant forest fragments have been largely disregarded as wildlife habitat, and little is known about mammalian use of these areas in Sumatra. Here, we conducted camera trap surveys (2285 trap-nights) within Bukit Barisan Selatan National Park and five surrounding remnant forest fragments during 2010–2013 and used species composition metrics to compare use. We found 28 mammal species in the protected forest and 21 in the fragments. The fragments harboured a subset of species found in the protected forest and several species not observed in the protected forest. Critically endangered species such as Sunda pangolin (Manis javanica) and Sumatran tiger (Panthera tigris sumatrae) were found in the forest fragments, along with species of conservation concern such as marbled cat (Pardofelis marmorata) and Asiatic golden cat (Pardofelis temminckii). The biodiversity found within the fragments suggests that these small patches of remnant forest may have conservation value to certain mammal species and indicates the importance of further research into the role these habitats may play in landscape-level, multispecies conservation planning. [ABSTRACT FROM AUTHOR]

Objective: The prevalence of Escherichia coli including from ice cubes in Indonesia is quite high. Unfortunately, little is known about the genetic diversity of E. coli from ice cube production site. Genotypic variation in E. coli populations is a major barrier to control public health risk associated with foodborne pathogen. The aims of this study were to analyze the genotypic diversity of E. coli strains isolated from various samples in order to determine the genetic relationship between those strains. This study is also important to understand the occurrence, prevalence and profile picture of different pathogenic E. coli in various sources which potentially cause disease., Results: Enterobacterial repetitive intergenic consensus (ERIC) and repetitive extragenic palindromic polymerase chain reaction (REP-PCR) dendrogram showed high genetic diversity of 120 E. coli isolates in majority of sampling sites. DNA fingerprint patterns showed 26 and 21 clusters with 11 and 3 fingerprints individual lineages for ERIC and REP-PCR respectively. There was no correlation observed between phylogenetic relationship and virulence genes. The result indicated a variation of E. coli isolates in ice cube manufacturers. ERIC-PCR method is more discriminative compared with REP-PCR to analyze the genetic diversity of E. coli from ice cubes production sites.

The majority of wild Sumatran tigers are believed to live in 12 Tiger Conservation Landscapes covering approximately 88,000 km(2) . However, the actual distribution of tigers across Sumatra has never been accurately mapped. Over the past 20 years, conservation efforts focused on the Sumatran tigers have increased, but the population continues to decline as a result of several key threats. To identify the status of the Sumatran tiger distribution across the island, an island-wide questionnaire survey comprised of 35 respondents from various backgrounds was conducted between May and June 2010. The survey found that Sumatran tigers are positively present in 27 habitat patches larger than 250 km(2) and possibly present in another 2. In addition, a review on major published studies on the Sumatran tiger was conducted to identify the current conservation status of the Sumatran tiger. Collectively, these studies have identified several key factors that have contributed to the decline of Sumatran tiger populations, including: forest habitat fragmentation and loss, direct killing of tigers and their prey, and the retaliatory killing of tigers due to conflict with villagers. The present paper provides management authorities and the international community with a recent assessment and a base map of the actual distribution of Sumatran tigers as well as a general overview on the current status and possible future conservation challenges of Sumatran tiger management., (© 2010 ISZS, Blackwell Publishing and IOZ/CAS.)