1. Antiplasmodial and other constituents from four Indonesian Garcinia spp.
- Author
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Elfita E, Muharni M, Latief M, Darwati D, Widiyantoro A, Supriyatna S, Bahti HH, Dachriyanus D, Cos P, Maes L, Foubert K, Apers S, and Pieters L
- Subjects
- Animals, Antimalarials chemistry, Antiprotozoal Agents chemistry, Antiprotozoal Agents isolation & purification, Antiprotozoal Agents pharmacology, Benzophenones chemistry, Benzophenones isolation & purification, Benzophenones pharmacology, Catechin chemistry, Catechin isolation & purification, Catechin pharmacology, Flavones chemistry, Flavones isolation & purification, Glucosides chemistry, Glucosides isolation & purification, Glucosides pharmacology, Indonesia, Lanosterol chemistry, Lanosterol isolation & purification, Lanosterol pharmacology, Molecular Structure, Plant Bark chemistry, Plant Leaves chemistry, Sitosterols chemistry, Sitosterols isolation & purification, Sitosterols pharmacology, Stigmasterol analogs & derivatives, Stigmasterol chemistry, Stigmasterol isolation & purification, Stigmasterol pharmacology, Triterpenes chemistry, Triterpenes isolation & purification, Triterpenes pharmacology, Xanthones chemistry, Antimalarials isolation & purification, Antimalarials pharmacology, Garcinia chemistry, Lanosterol analogs & derivatives, Plants, Medicinal chemistry, Plasmodium falciparum drug effects, Xanthones isolation & purification, Xanthones pharmacology
- Abstract
Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, beta-sitosterol-3-O-beta-D-glucoside and stigmasterol-3-O-beta-D-glucoside from the stem bark of G. griffithii; friedelin and 3beta-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (+/-)-morelloflavone, morelloflavone-7-O-beta-D-glucoside or fukugiside, the triterpene 3beta-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene beta-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.
- Published
- 2009
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