1. A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge.
- Author
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Balansa W, Mettal U, Wuisan ZG, Plubrukarn A, Ijong FG, Liu Y, and Schäberle TF
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Bacillus megaterium drug effects, Biological Products isolation & purification, Indonesia, Microbial Sensitivity Tests, Micrococcus luteus drug effects, Molecular Structure, Quinones chemistry, Quinones isolation & purification, Sesquiterpenes chemistry, Sesquiterpenes isolation & purification, Anti-Bacterial Agents pharmacology, Biological Products pharmacology, Porifera chemistry, Quinones pharmacology, Sesquiterpenes pharmacology
- Abstract
Sponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to the discovery of four merosesquiterpenoids, namely, a new sesquiterpenoid aminoquinone nakijiquinone V ( 1 ), along with illimaquinone ( 2 ), smenospongine ( 3 ), and dyctioceratine C ( 4 ). The structure of compound 1 was elucidated by 1D and 2D NMR as well as by LC-HRESIMS data analysis. Compounds 2 ⁻ 4 showed moderate to low antimicrobial activity against Bacillus megaterium DSM32 with a minimum inhibitory concentration (MIC) of 32 μg/mL, 32 μg/mL, and 64 μg/mL, respectively. Furthermore, compounds 2 and 3 both inhibited Micrococcus luteus ATCC 4698 with a MIC of 32 μg/mL. In conclusion, the isolated merosesquiterpenoids, which are known for their cytotoxic effects, showed antibacterial activity and prompt future structure activity relationship (SAR) studies concerning the various bioactivities observed for this group of natural products.
- Published
- 2019
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