1. Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
- Author
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Seo EK, Kim NC, Wani MC, Wall ME, Navarro HA, Burgess JP, Kawanishi K, Kardono LB, Riswan S, Rose WC, Fairchild CR, Farnsworth NR, and Kinghorn AD
- Subjects
- Animals, Anthracenes chemistry, Anthracenes pharmacology, Anthraquinones chemistry, Anthraquinones pharmacology, Benzophenones chemistry, Benzophenones pharmacology, Chromatography, High Pressure Liquid, Drug Screening Assays, Antitumor, Humans, Indonesia, KB Cells drug effects, Leukemia P388, Mice, Mice, Inbred DBA, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark chemistry, Plant Leaves chemistry, Plant Stems chemistry, Tumor Cells, Cultured drug effects, Vitamin E chemistry, Vitamin E isolation & purification, Vitamin E pharmacology, Xanthenes chemistry, Anthracenes isolation & purification, Anthraquinones isolation & purification, Benzophenones isolation & purification, Plants, Medicinal chemistry, Vitamin E analogs & derivatives, Xanthenes isolation & purification, Xanthones
- Abstract
Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.
- Published
- 2002
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