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This study aims to examine the current experiences of high school students in computer science (CS) courses and the factors that motivated them to continue their future enrollment. The participants were 603 high school students in grades 9 through 12 in Indiana, all of whom enrolled in at least one CS course during the 2020-2021 academic year. This research revealed that fun and meaningful CS pedagogy, knowledgeable CS teachers, and relevance to their lives and future careers enabled high school students to hold positive experiences in their CS classes. These experiences impacted students to take additional CS courses. In addition to these positive experiences, gender and early exposure to CS emerge as predictors to pursue CS courses. The findings will carry significance for policymakers and educators offering insights to enhance and broaden students' participation and engagement in the CS course.

This study aims to investigate the licensure status of computer science teachers in Indiana by examining teacher licensure data as it relates to school locale and school demographics across the state. Results indicate that there is no significant difference in the presence of teachers with CS-Related or Approved licenses across schools with various locale designations and demographic (ethnic and economic) compositions. It is a positive indication that there are no glaring disparities in access to well-prepared CS teachers across student groups. This also provides an opportunity to investigate additional factors that may shed light on future areas of focus.

Rationale: The long-acting β2-agonist/long-acting muscarinic antagonist combination indacaterol/glycopyrronium (IND/GLY) elicits bronchodilation, improves symptoms, and reduces exacerbations in COPD. Magnetic resonance imaging (MRI) of the lung with hyperpolarized gas and gadolinium contrast enhancement enables assessment of whole lung functional responses to IND/GLY.Objectives: The primary objective was assessment of effect of IND/GLY on global ventilated lung volume (%VV) versus placebo in COPD. Lung function, regional ventilation and perfusion in response to IND/GLY were also measured.Methods: This double-blind, randomized, placebo-controlled, crossover study assessed %VV and pulmonary perfusion in patients with moderate-to-severe COPD after 8 days of once-daily IND/GLY treatment (110/50 µg) followed by 8 days of placebo, or vice versa, using inhaled hyperpolarized 3He gas and gadolinium contrast-enhanced MRI, respectively. Lung function measures including spirometry were performed for each treatment after 8 days.Measurements and Main Results: Of 31 patients randomized, 29 completed both treatment periods. IND/GLY increased global %VV versus placebo (61.73% vs. 56.73%, respectively, least squares means treatment difference: 5.00% [90% CI 1.40 to 8.60]; P = 0.025). IND/GLY improved whole lung index of ventilation volume to perfusion volume (V/Q) ratio versus placebo; 94% (90% CI 83 to 105) versus 86% (90% CI 75 to 97; P = 0.047), respectively. IND/GLY showed a trend to improve diffusing capacity for carbon monoxide (DLCO) (+ 0.66 mL/min/mmHg; P = 0.082). By Day 8, forced expiratory volume in 1 s (FEV1) was increased by 0.32 L versus placebo (90% CI 0.26 to 0.38; P < 0.0001), substantiating earlier findings and providing evidence of assay sensitivity for this trial.Conclusions: IND/GLY improved lung ventilation assessed by 3He MRI after 1 week of treatment. This observation may provide mechanistic support for the symptomatic clinical benefit shown with IND/GLY in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT02634983). [ABSTRACT FROM AUTHOR]