1. A new cembranoid from the Red Sea soft coral Sarcophyton acutum .
- Author
-
Mohamed TA, Abdelmawgoud SM, Hamdy AA, Ibrahim MAA, Elshamy AI, Atia MAM, Kassem HA, Hegazy MF, and Selim NM
- Subjects
- Animals, Humans, Molecular Structure, Indian Ocean, HeLa Cells, Diterpenes pharmacology, Diterpenes chemistry, Anthozoa chemistry, Colorectal Neoplasms
- Abstract
The Red Sea soft coral Sarcophyton acutum ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A ( 1 ), along with six known metabolites have been isolated from S. acutum for the first time ( 2-7 ). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A ( 1 ) and gorgosterol ( 7 ) inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC
50 values of 35.5 and 44.0 μM, respectively.- Published
- 2024
- Full Text
- View/download PDF