1. NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.
- Author
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Rojas LJ, Hujer AM, Rudin SD, Wright MS, Domitrovic TN, Marshall SH, Hujer KM, Richter SS, Cober E, Perez F, Adams MD, van Duin D, and Bonomo RA
- Subjects
- Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Carbapenems pharmacology, Carbapenems therapeutic use, Humans, India, Klebsiella Infections drug therapy, Klebsiella Infections microbiology, Male, Microbial Sensitivity Tests, Plasmids genetics, beta-Lactamases genetics, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae pathogenicity, beta-Lactamases metabolism
- Abstract
Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring bla
NDM-5 from a young man who underwent abdominal surgery in India. blaOXA-181 from a young man who underwent abdominal surgery in India. blaNDM-5 was located on an IncFII plasmid of ≈90 kb, whereas blaOXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS 26 and a "hot-spot region" in the IncFII plasmid., (Copyright © 2017 American Society for Microbiology.)- Published
- 2017
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