1. Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort.
- Author
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Shah, Ravikumar, Gosavi, Vikrant, Mahajan, Abhishek, Sonawane, Sushil, Hira, Priya, Kurki, Vineeth, Bal, Munita, Sathe, Pragati, Pai, Prathamesh, D'Cruz, Anil, Uchino, Shinya, Garale, Mahadeo Namdeo, Patil, Virendra, Lila, Anurag, Shah, Nalini, and Bandgar, Tushar
- Subjects
INDIANS (Asians) ,PARATHYROID glands ,CARCINOMA ,FORECASTING ,DIAGNOSIS - Abstract
Background: Parathyroid carcinoma (PC) requires preoperative prediction for appropriate surgical management. Differentiation from symptomatic primary hyperparathyroidism (sPHPT) cohort is difficult. Methods: Patients with sPHPT from a tertiary‐care center, Western India, including Cohort‐A (n = 19 [10/M; 9/F]) with PC and Cohort‐B (n = 93 [33/M; 60/F] with benign parathyroid lesions) were compared to derive predictors for differential diagnosis. Results: There were no differences in clinical or biochemical parameters between the two cohorts. Comparison of CECT parameters showed that irregular shape, tumor heterogeneity, infiltration, short/long‐axis ratio >0.76, and long‐diameter >30 mm had high negative‐predictive value and intratumoral calcification had 100% positive‐predictive value to diagnose PC; whereas there were no differences in contrast‐enhancement patterns. Long diameter, short/long‐axis ratio, and heterogeneity were significant predictors on multivariate analysis. Conclusion: It is difficult to predict diagnosis of PC in an Indian sPHPT cohort based on clinical and biochemical parameters, whereas CECT parathyroid‐based parameters can aid in diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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