1. Low-molecular-weight heparin salvage in pedicled flap reconstruction in head and neck: a prospective cohort study.
- Author
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Panda, Smriti, Gautam, Vimmi, Mitra, Sandipta, Singh, Chirom Amit, Mani, Suresh, Palreddy, Akshara, Kabilan, Yuvanesh, Konkimalla, Abhilash, Kondamudi, Dheeraj, Bagchi, Debadeep, Raveendran, Sarath, Sikka, Kapil, Kumar, Rajeev, Singh, Anup, and Thakar, Alok
- Subjects
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LOW-molecular-weight heparin , *T-test (Statistics) , *SALVAGE therapy , *HEAD & neck cancer , *VEINS , *NECROSIS , *FISHER exact test , *LOGISTIC regression analysis , *PROBABILITY theory , *TREATMENT effectiveness , *CHI-squared test , *MULTIVARIATE analysis , *DESCRIPTIVE statistics , *DALTEPARIN (Drug) , *SURGICAL flaps , *LONGITUDINAL method , *ENOXAPARIN , *ODDS ratio , *THROMBOEMBOLISM , *STATISTICS , *PLASTIC surgery , *EVALUATION ,THROMBOEMBOLISM prevention - Abstract
Objective: To determine if systemic administration of low-molecular-weight heparin impacts venous compromise in loco-regional flap reconstruction for head and neck subsites. Methods: This prospective study was conducted on patients who had developed features of venous compromise of the flap. The case group received low-molecular-weight heparin (dalteparin). Results: Of the 73 patients who developed venous congestion, low-molecular-weight heparin was administered in 47 patients. In the low-molecular-weight heparin subset, 23 patients had either reversal or non-progression of venous compromise (48.9 per cent). Of the patients who had no response to low-molecular-weight heparin rescue, complete necrosis was seen in 4 and partial flap necrosis was observed in 19. The corresponding numbers in the control group were 13 and 12, respectively (odds ratio 23.9, p = 0.002). Additionally, the low-molecular-weight heparin arm had a lower incidence of partial or complete flap necrosis (p = 0.002). Conclusion: Low-molecular-weight heparin salvage, when instituted early, is likely to result in a significant reduction in flap-related morbidity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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