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Background: Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer incidence and tumor anatomical features at diagnosis, pharmacogenomics data between Western and Indian women along with the vast diversity in the economic status and differences in insurance policies of these regions; suggest recommendations put forward for Western women might not be applicable to Indian/Asian women. Opinions from oncologists through a voting survey on various prognostic factors/tools to be considered for planning adjuvant therapy are consolidated in this report for the benefit of oncologists of the sub-continent, SAARC and Asia's LMIC (low and middle-income countries). Methods: A three-phase DELPHI survey was conducted to collect opinions on prognostic factors considered for planning adjuvant therapy in early-stage HR+/HER2/neu negative breast cancer patients. A panel of 25 oncologists with expertise in breast cancer participated in the survey conducted in 2021. The experts provided opinions as 'agree' or disagree' or 'not sure' in phases-1 and 2 which were conducted virtually; in the final phase-3, all the panel experts met in person and concluded the survey. Results: Opinions on 41 statements related to prognostic factors/tools and their implications in planning adjuvant endocrine/chemotherapy were collected. All the statements were supported by the latest data from the clinical trials (prospective/retrospective). The statements with opinions of consensus less than 66% were disseminated in phase-2, and later in phase-3 with supporting literature. In phase-3, all the opinions from panelists were consolidated and guidelines were framed. Conclusions: This consensus guideline will assist oncologists of India, SAARC and LMIC countries in informed clinical decision-making on adjuvant treatment in early HR+/HER2/neu negative breast cancer patients. [ABSTRACT FROM AUTHOR]

Legumes play an important role in India's food security, inflation rate and export values. Climate variability might significantly affect the growth, development and yield of legume crops in various regions of the globe. The present study investigated the long episodes effect of high temperature and CO2 and ambient conditions on leaf photosynthesis and yield attributes of green gram (Vigna radiata) using soil plant atmospheric research (SPAR). Green gram was grown under high day temperature (HDT) (day maximum temperature + 3°C) and elevated CO2 (600ppm) (HDT and eCO2), high day and night temperature (HDNT) (day maximum temperature + 3°C) and elevated CO2 (600ppm) (HDNT and eCO2) and ambient conditions. Leaf photosynthesis, stomatal conductance, transpiration rate and chlorophyll index were significantly (p=0.05) increased by 25%, 24.1%, 23% and 4.6%, respectively, under HDT and eCO2 from 30 to 45 DAS (days after sowing) in comparison with ambient and HDNT and eCO2. The significant increase in number of flowers shed per plant increased under HDNT and eCO2 by 13% during 45 to 60 DAS. The increase in the number of pods per plant and grain yield per plant under HDT and eCO2 during 45 to 60 DAS by 26.9% and 25.7%, respectively. However, the biomass of the green gram was increased under HDNT and eCO2 during 30 to 45 DAS. These studies indicated a significant increase in leaf photosynthesis and yield of green gram under HDT and eCO2 at flower initiation to pod development stage (30 to 60 DAS) followed by HDNT and eCO2 and ambient condition. Overall study indicated that increasing temperature and CO2 would increase the biomass and yield of the green gram. [ABSTRACT FROM AUTHOR]

To interpret a correlation between buccolingual inclination of molars and palatal depth in hyperdivergent patients and to identify importance of determining inclination of molars in assessing transverse discrepancies (as skeletal or dental) This was a retrospective cone beam computed tomography (CBCT) study. The study was conducted in the Department of Orthodontics, Saveetha Dental College and Hospital, Tamil Nadu, India. This was a retrospective CBCT study of 79 patients who underwent diagnostic CBCT for treatment purposes. The CBCT scans were evaluated systematically and the required parameters were accessed with suitable reference planes. Student's t-test (95% confidence interval) was performed to determine buccolingual inclination of first molars between the right and left sides. Only patients with a vertical growth pattern and skeletal class I relation were included and they were classified into three groups based on their palate depth. In patients with palatal depth > 22 mm, the mean inclination of molars was 7.4°; with palatal depth in the range of 19–22 mm, the mean inclination of molars was 5.23°; and with palatal depth < 19 mm, the mean inclination of molars was 2.9°. Results showed that there was a significant correlation between the buccolingual inclination of molars and the palate depth in vertical growers (P < 0.05). The buccolingual inclination of first molars is increased in patients with greater palatal depth. This parameter is helpful in classifying crossbites as skeletal or dental. The amount of compensation required to correct the cross bite can be adjusted using Korkhaus Index. [ABSTRACT FROM AUTHOR]

Introduction: Through much history of mankind, the overt manifestation of bodyweight gain in children and adults have been considered as a sign of personal health and family wealth and an indicator of the economic prosperity of the society. As developing societies are industrialised and urbanised, the standards of living continued to rise; obesity and weight gain began to pose a growing threat to the health of the citizens. Aim: To determine the prevalence of forearm bones fracture in obese and non-obese children between age group of 2-15 years. Materials and Methods: A cross-sectional study was conducted in the Department of Orthopaedics and Paediatrics at Dr BC Roy Post Graduate Institute of Paediatric Science, Kolkata, West Bengal, India from September 2017 to October 2018. Children were classified into obese and non-obese group according to Body Mass Index (BMI). Calculation of BMI was done by the formula BMI=weight (kg)/{height(m)}2 . Obese children were determined by the BMI percentile by plotting the BMI number on the appropriate Centers for Diseases Control and Prevention (CDC) BMI-for-age growth chart. Doubtful cases classification was confirmed by the paediatric surgeon. Injury mechanism was graded into three trauma kinetics (direct trauma, slow motion trauma and high motion trauma). The validated paediatric Physical Activity Questionnaire (PAQ-A and PAQ-C) were used to grade the average daily activities during the week prior to trauma. Statistical analysis was done by using the Chi-square test and p-value of <0.05 was considered to be statistically significant. Results: Total 583 children were treated during the study period in the hospital including both Outpatient Department (OPD) and Emergency Department. About 433 children were excluded due to below age two years, refracture, chronic illness, and major congenital malformation. Among them only 150 patients met the criteria of present study. Out of 150 children, 69 (46%) were found obese and non-obese were 81 (54%). The distribution by gender was the same in obese group which had 26 (37.68%) female and 43 (62.32%) male, in non-obese group 34 (41.97%) female and 47 (58.03%) male. It was observed that both bones fracture of forearm in obese children was more at risk than non-obese children, p-value of <0.5 which was statistically significant. Conclusion: Present study shows higher prevalence of forearm bone fracture in obese children than non-obese children. Obesity and other certain factors might have been significant risk factor for fracture required for operation. Both radius-ulna fracture in obese were found significant. [ABSTRACT FROM AUTHOR]

Non‐centrifugal sugar (NCS) industry is one of the oldest small‐scale cottage industries in India, with crude and inferior production techniques. Toward transforming these inferior techniques for the sustenance of NCS industry, it is necessary to select sustainable methods among the existing technologies at various stages in the production process. In the production of NCS, juice extraction is the primary and essential process. The present article gives an insight in selecting a sustainable juice extraction technology using various decision approaches. Analytic hierarchy process (AHP) integrated multi‐criteria decision‐making (MCDM) is the decision approaches used for selecting the appropriate juice extraction technique among 6 alternatives based on 11 criteria covering various sustainable factors. Through this MCDM approach, it was obtained that crusher with single horizontal roller that uses electrical motor without any usage of hot water is the most sustainable juice extraction method for NCS production in plant mode with 1.38 group priority weight. On the other hand, crusher with single vertical roller that runs on electrical energy without usage of hot water and crusher with single horizontal roller that runs on diesel engines without the usage of hot water is a comparatively least preferred alternative for NCS production with 3.33 and 3.39 group priority weight, respectively. Practical Applications: This article narrates the novel work undertaken to identify a sustainable crushing technology for extracting sugarcane juice to produce non‐centrifugal sugar.The analysis is carried out to select the most appropriate technology among 6 crushing technologies based on 11 evaluation criteria spreading across various aspects of sustainability.The analysis used three multi‐criteria decision‐making (MCDM) methods namely TOPSIS, PROMETHEE, and VIKOR.Based on this analysis it is found that single horizontal crusher that run on electricity without the use of hot water (SHEN) is the best juice extraction technology.Hence, this technology could be used by the non‐centrifugal sugar (NCS) industry to produce NCS in a sustainable way.Further, the methodology presented in this article, demonstrates the use of such methods to identify the better processes/subprocesses to produce NCS in a sustainable way. [ABSTRACT FROM AUTHOR]

Background: Benzene, which is a major organic product, on chronic exposure can result in many malignant disorders, and therefore exposure to gasoline vapors is classified by the International Agency for Research of Cancer as possible carcinogenic to humans. Petrol station attendants are chronically exposed to petroleum derivatives through inhalation of petrol during vehicle refuelling. Aim: This study is aimed to investigate cytogenotoxic damage in exfoliated buccal cells obtained from petrol station workers and control subjects using micronucleus (MN) test. Materials and Methods: This study was carried out on 30 petrol station attendants working at different petrol stations located in Indore. The control group consisted of 30 healthy subjects who were not exposed to benzene. Buccal cell samples were collected at the end of the work shift. Slides were stained and were evaluated to determine the MN frequencies. Exposure monitoring was performed by the detection of phenol excreted in the urine. Urinary phenol measurements were performed following the colorimetric quantitative determination method of Yamaguchi and Hayashi. Results: Variations in MN frequencies were seen in control and petrol bunk attendants. Conclusion: The MN test in exfoliated epithelial cells seems to be a useful biomarker of occupational exposure to genotoxic chemicals. Phenol is the principal metabolite of benzene. Therefore, phenol concentration in the urine of exposed workers can be used as a biomarker of external exposure. [ABSTRACT FROM AUTHOR]

Abstract: The Indian armed forces have over 5000 cases of human immunodeficiency virus (HIV) infection since 1990. The spouses of the affected soldiers are at a constant risk of contracting infection if not informed of their husband''s HIV status. The onus of counselling the spouse has been delegated to the commanding officer (CO) of the soldier as per policy. The spouses usually reside at their hometown away from the soldier''s unit and bridging this “geographical discordance” and offering effective counselling becomes a tricky issue for the commanding officer (CO). This article examines the effectiveness of this strategy as practised in Indian armed forces. [Copyright &y& Elsevier]

The article focuses on the implementation of various plans and policies related to child in India with respect to child mental health, education, and welfare. Topics include government policies and national program for promoting child mental health; gap between the children's needs and existing resources; and problems such as underweight, and iodine deficiency among Indian children.