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Introduction: India has the second largest HIV epidemic in the world. Despite successes in epidemic control at the population level, a concentrated epidemic persists among gay and other men who have sex with men (MSM). However, India lags in implementation of biomedical prevention technologies, such as HIV pre-exposure prophylaxis (PrEP). In order to inform scale-up of new HIV prevention technologies, including those in the development pipeline, we assessed willingness to use oral PrEP, rectal microbicides, and HIV vaccines, and choices among product characteristics, among MSM in two major Indian cities. Methods: A cross-sectional survey was conducted with a discrete choice experiment (DCE), an established methodology for quantitively estimating end-user preferences in healthcare. Survey participants were randomly assigned to one of three questionnaire versions, each of which included a DCE for one prevention technology. Participants were recruited using chain-referral sampling by peer outreach workers, beginning with seeds in community-based organizations and public sex environments, in Chennai and Mumbai. DCE data were analyzed using random-parameters (mixed) logit (RPL) models. Results: Among participants (n = 600), median age was 25 years, with median monthly income of INR 9,000 (~US$125). Nearly one-third (32%) had completed a college degree and 82% were single/never married. A majority of participants (63%) reported condomless anal sex in the past month. The acceptability of all three products was universally high (≥90%). Across all three products, four attributes were significant predictors of acceptability—with efficacy consistently the most important attribute, and in decreasing order of preference, side-effects, dosing schedule, and venue. MSM varied in their preferences for product attributes in relation to their levels of education and income, and engagement in sex work and HIV risk behavior. Conclusion: This study provides empirical evidence to facilitate the integration of end users' preferences throughout design, testing, and dissemination phases of HIV prevention technologies. The findings also suggest action points and targets for interventions for diverse subgroups to support the effectiveness of combination HIV prevention among MSM in India. [ABSTRACT FROM AUTHOR]

Reducing the stigma and discrimination faced by men who have sex with men (MSM) and transgender women (TGW) in healthcare settings is key to improving health outcomes. Using a one-group pre- and post-test design, we tested the efficacy of a theory-informed, multi-level pilot intervention ("Harmony") among 98 healthcare workers (HCWs) to reduce sexual orientation and gender identity (SOGI)-related stigma and discrimination faced by MSM and TGW in two public hospitals. The intervention contained group-level (a half-day workshop) and individual-level (four videos) components. Using multi-level modelling, we compared knowledge, attitudes, and comfort level among HCWs across three timepoints: pre-intervention, post-intervention, and follow-up (2 months after the intervention). Client surveys were conducted among 400 MSM/TGW (two independent samples of 200 MSM/TGW) attending the intervention hospitals, before the intervention among HCWs and three months after the intervention. Generalised estimating equations assessed service users' satisfaction with hospital services, discrimination experiences, and positive interactions with HCWs. Significant changes were observed in primary outcomes: 30% increase in positive attitude scores (incidence rate ratio (IRR) = 1.30, 95% CI 1.13–1.49) and 23% increase in the proportion of HCWs reporting being comfortable in providing care to MSM/TGW (IRR = 1.23, 95% CI 0.03–1.68). Similarly, there was a significant improvement in secondary outcomes (scores): support for non-discriminatory hospital policies (IRR = 1.08, 95% CI 1.004–1.15), the importance of asking SOGI questions in clinical history (IRR = 1.17, 95% CI 1.06–1.29), and perceived self-efficacy in providing clinical care (IRR = 1.13, 95% CI 1.01–1.27). Service users' data provided corroborative evidence for intervention efficacy: e.g., 14% increase in the proportion of MSM reporting overall satisfaction with hospital services and 6% and 15% increase in the scores of positive interactions with HCWs in the combined sample of MSM/TGW and TGW, respectively. The Harmony intervention showed preliminary evidence for improving positive attitudes, comfort level, and understanding of the healthcare issues of MSM/TGW among HCWs, warranting large-scale implementation research. [ABSTRACT FROM AUTHOR]

Environmental sustainability encompasses various problems, including clean air, renewable energy, climate change, safe environments, and the capacity to live in a healthy community. One possible strategy for addressing these global problems is the circular bio-economy. Cleaner and lower-carbon environments may be fostered via the production of bioenergy and biomaterials, which can also help to maintain the energy-environment connection. To improve sustainability and the state of the planet, scientists are looking at renewable energy sources like ethanol. Compared to gasoline, ethanol has a reduced carbon footprint and a greater energy density, making it a viable alternative fuel. This study gives an overview of ethanol as a possible alternative fuel for flex-powered power generators in India to meet the goals of the circular bio-economy. This paper details the results of flex-fuel testing conducted on a light-duty power generator using an ethanol-gasoline mix. The findings reveal improved thermal efficiency and lower fuel consumption rates than basic fuel. The emissions of both carbon monoxide and unburned hydrocarbons were shown to be reduced. [ABSTRACT FROM AUTHOR]

Hybrid photovoltaic-thermal heat pump (PV/T-HP) solar energy systems are promising since they can achieve a system total efficiency greater than 80%. By maximizing the output of a PV/T system for simultaneous heating and cooling, this strategy can meet over 60% of urban households' heating needs and around 40% of their cooling needs. In this work, a novel PV/T evaporator was designed, fabricated, and an aluminium foil encapsulated hydrated salt (HS36) PCM was integrated with the PV/T evaporator of the PV/T direct expansion heat pump system (PV/T-DXHP). Energy analysis was carried out on the PV/T-DXHP system with PCM in tropical climate regions of India for achieving net zero energy buildings. The experimental study revealed that the average PV electricity efficiency was 14.17%, which is near the PV panel's STC value. The average thermal efficiency of the system was 104.38%, and the PV/T system's average overall efficiency was 117.58%. The heating and cooling COPs of the system were 5.73 and 4.62, respectively. It was concluded that net-zero energy buildings are possible with the help of photovoltaic heat pump systems that use PCM and solar energy to make electricity, cool spaces, and heat water. [ABSTRACT FROM AUTHOR]

Limited data is available on the associations between intersectional stigmas and mental health outcomes among men who have sex with men living with HIV (MSMLH) in India. The minority stress model postulates that sexual stigma contributes to depression through proximal stressors like internalized homonegativity (IHN). Using cross-sectional survey data from 119 MSMLH in 2015/16, we tested whether: (1) sexual stigma and enacted HIV stigma (EHS) are associated with depression; (2) their effects on depression are mediated through IHN and internalized HIV stigma (IHS); and (3) their effects on IHN are mediated through IHS. Significant direct associations were observed between scores on sexual stigma and IHS (β =.49, 95% CI.27,.70), EHS and IHN (β =.19, 95% CI.03,.36), and IHS and IHN (β =.07, 95% CI.03,.12). IHS scores mediated the associations of sexual stigma with depression (β =.17, 95% CI.07,.27) and IHN scores (β =.04, 95% CI.004,.07). EHS was not found to be significantly associated with depression or IHN. The findings partially support the minority stress model among MSMLH and highlight the importance of addressing both sexual and HIV-related stigmas to improve mental health of MSMLH, especially by screening for and reducing IHS, IHN and depression. [ABSTRACT FROM AUTHOR]

Research on transmasculine people's health is scant globally, including in India. We explored transmasculine people's experiences in affirming their gender in family and social spaces, and how those experiences impact mental health. In 2019, we conducted four focus groups (n = 17 participants) and 10 in-depth interviews with transmasculine people in Mumbai and Chennai. Data analyses were guided by minority stress theory and the gender affirmation model. Within family, the pressure to conform to assigned gender roles and gender policing usually began in adolescence and increased over time. Some participants left parental homes due to violence. In educational settings, participants described the enforcement of gender-normative dress codes, lack of faculty support, and bullying victimisation, which led some to quit schooling. In the workplace, experiences varied depending on whether participants were visibly trans or had an incongruence between their identity documents and gender identity. Everyday discrimination experiences in diverse settings contributed to psychological distress. Amidst these challenges, participants reported resilience strategies, including self-acceptance, connecting with peers, strategic (non)disclosure, and circumventing gendered restrictions on dress and behaviour. Interventions at social-structural, institutional, family and individual levels are needed to reduce stigma and discrimination faced by transmasculine people in India and to promote their mental health. [ABSTRACT FROM AUTHOR]

HIV pre-exposure prophylaxis (PrEP) is not yet included in India's national AIDS program, with demonstration projects for MSM in planning stages. In order to support PrEP roll-out for MSM, we assessed: (1) associations between guideline-informed PrEP eligibility, HIV risk perception, and perceived PrEP benefits and costs, with willingness to use PrEP (WTUP); and (2) correlates of non-WTUP among PrEP-eligible MSM. Data were collected from MSM (n = 197) sampled from cruising sites in Mumbai and Chennai. More than half (58.4%) reported inconsistent condom use with male partners, 88.3% >1 male partner, and 48.6% engaging in sex work (all past month). Overall, 76.6% reported they would "definitely use" PrEP. Among 92.9% deemed PrEP-eligible, 79.2% reported WTUP. In adjusted analyses, PrEP eligibility (aOR = 5.31, 95% CI 1.11, 25.45), medium (aOR = 2.41, 95% CI 1.03, 5.63) or high (aOR = 13.08, 95% CI 1.29, 132.27) perceived HIV risk, and greater perceived benefits (aOR = 1.13, 95% CI 1.03, 1.24) were associated with higher odds of WTUP. Among PrEP-eligible MSM, non-WTUP was associated with low HIV risk perception and lower perceived benefits. Facilitating accurate risk assessment and promoting awareness of PrEP benefits and eligibility criteria may increase PrEP uptake among MSM in India. [ABSTRACT FROM AUTHOR]

Antimicrobial resistance (AMR) in poultry production chain is one of the major food safety concerns due to indiscriminate usage of antibiotics and the presence of pathogens such as Salmonella which causes infections in various stages of production. In the present study, 182 samples were collected from commercial broiler supply chain, viz., three hatcheries (n = 29), three commercial broiler farms (CBF; n = 99), and three retail meat shops (RMS; n = 54), and used for isolation and identification of Salmonella using three different selective agar media and a selective enrichment medium followed by PCR confirmation targeting the hilA gene. The overall prevalence of Salmonella was 47/182 (25.82%), and a significantly higher (P < 0.05) prevalence was observed in retail meat shops (46.29%), CBF (19.19%), and hatcheries (10.34%). Comparison of three agar media for isolation of Salmonella revealed that all the media were equally selective. However, PCR amplification of hilA gene fragment was significantly higher (P < 0.01) in selective enrichment culture tetrathionate brilliant green bile broth (TTB) as compared to all solid (agar-based) media. Susceptibility pattern against most frequently used antibiotics revealed that 100% of the isolates were resistant to at least one antibiotic. High resistance was observed for doxycycline (94.34%), followed by cefpodoxime (84.91%), ciprofloxacin (72.64%), gentamicin (65.09%), enrofloxacin (61.32%), colistin sulphate (40.42%), amikacin (34.91%), ampicillin (33.96%), neomycin (33.02), cefotaxime (30.19%), ceftazidime (29.25%), trimethoprim-sulfamethoxazole (23.58%), amoxicillin+clavulanic acid (21.70%), and chloramphenicol (12.26%); 16.98% of the isolates were ex-tended spectrum β-lactamase (ESBL) producers, and 76.41% were multidrug resistant (MDR). MDR Salmonella were significantly higher (P < 0.01) in RMS (91.66%) followed by CBF (82.75%), whereas no MDR isolates were present in the isolates from hatcheries. The results indicated a higher prevalence of Salmonella and AMR for commonly used antibiotics in the complete broiler supply chain, especially RMS and CBF. Also, this study idicated that TTB enrichment followed by PCR and colony PCR was found to be rapid, specific and time-saving method. [ABSTRACT FROM AUTHOR]

The present study was conducted to evaluate the prevalence and enterotoxin gene profiles of Staphylococcus aureus isolated from 120 chicken meat marketed in retail outlets of Chennai, India. It was observed that total of 120 meat samples collected from different retail outlets, 66.67% (80/120) of the samples were positive for the presence of S. aureus based on biochemical characterization and species specific PCR based on thermonuclease gene (nuc). Enterotoxin gene profiling of the isolates for 9 genes (sea- sej) revealed that 52.50% (42/80) of the isolates in the present study were enterotoxigenic harboring either one or more gene. It was evident that majority of the isolates harbored seb, followed by seg, sei, sec, sed and sej either alone or in combination. None of the isolates harbored sea, see and seh either alone or in combination. The results of the study clearly indicated higher prevalence of enterotoxigenic S. aureus in retail meat marketed in Chennai, India indicating the potential of retail chicken meat to act as vehicle for food borne intoxication and a major public health threat. [ABSTRACT FROM AUTHOR]

Pre-exposure prophylaxis (PrEP) programs are planned for key populations in India. We examined PrEP awareness and willingness to use PrEP in order to support products and services for MSM. From December 2016 to March 2017, we conducted a survey and discrete choice experiment (DCE)—a technique to quantify the strength of participants' trade-off preferences among various product attributes—to assess willingness to use PrEP and related preferences. MSM were recruited from cruising sites and HIV prevention services in Mumbai and Chennai. DCE data were analyzed using mixed logit regression models and estimated marginal willingness-to-pay, the relative value participants' place on different PrEP attributes. Overall, 76.6% indicated willingness to use PrEP. Efficacy had the greatest effect on choice (high vs. moderate, aOR = 19.9; 95% CI 13.0–30.4), followed by dosing frequency (intermittent vs. daily regimen, aOR = 2.02; 95% CI 1.8–2.2). Participants preferred no (vs. minor) side-effects, subsidized (vs. market) price, and government (vs. private) hospitals. Findings suggest that educational and social marketing interventions should emphasize PrEP's high efficacy and minimal side effects, and programs should provide government-subsidized PrEP with choices of intermittent or daily dosing delivered by government and private hospitals/clinics in order to optimize PrEP uptake among MSM in India. [ABSTRACT FROM AUTHOR]

Context: Increased bone fragility and reduced energy absorption to fracture associated with type 2 diabetes (T2D) cannot be explained by bone mineral density alone. This study, for the first time, reports on alterations in bone tissue's material properties obtained from individuals with diabetes and known fragility fracture status.Objective: To investigate the role of T2D in altering biomechanical, microstructural, and compositional properties of bone in individuals with fragility fracture.Methods: Femoral head bone tissue specimens were collected from patients who underwent replacement surgery for fragility hip fracture. Trabecular bone quality parameters were compared in samples of 2 groups, nondiabetic (n = 40) and diabetic (n = 30), with a mean duration of disease 7.5 ± 2.8 years.Results: No significant difference was observed in aBMD between the groups. Bone volume fraction (BV/TV) was lower in the diabetic group due to fewer and thinner trabeculae. The apparent-level toughness and postyield energy were lower in those with diabetes. Tissue-level (nanoindentation) modulus and hardness were lower in this group. Compositional differences in the diabetic group included lower mineral:matrix, wider mineral crystals, and bone collagen modifications-higher total fluorescent advanced glycation end-products (fAGEs), higher nonenzymatic cross-link ratio (NE-xLR), and altered secondary structure (amide bands). There was a strong inverse correlation between NE-xLR and postyield strain, fAGEs and postyield energy, and fAGEs and toughness.Conclusion: The current study is novel in examining bone tissue in T2D following first hip fragility fracture. Our findings provide evidence of hyperglycemia's detrimental effects on trabecular bone quality at multiple scales leading to lower energy absorption and toughness indicative of increased propensity to bone fragility. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic and its health, economic and social aftermath has currently overshadowed every other health concern throughout the world. There are numerous ways in which this will impact existing public health issues. In this article we aim to examine and reflect on the interactions between COVID-19 and tuberculosis (TB) another scourge which has long been the world's leading infectious killer. There are potentially grave consequences for existing and undiagnosed TB patients globally, particularly in low and middle income countries like India where TB is endemic and health services poorly equipped. TB control programmes are likely to be strained due to diversion of resources, and an inevitable loss of health system focus. This is likely to lead to a reduction in quality of TB care and worse outcomes. The symptoms of TB and COVID-19 can be similar, for instance symptoms like cough and fever. Not only can this create diagnostic confusion, but it could worsen the stigmatization of TB patients especially in LMICs, given the fear of COVID-19. Women with TB in India are a vulnerable group as gender disparities play a significant role in how men and women access healthcare in the public and private sectors. They are especially likely to suffer as part of the "collateral damage" and also experience the impact of the double stigma disproportionately. In this paper the researchers examine the impact of Covid 19 on women seeking TB care in India. [ABSTRACT FROM AUTHOR]

HIV-positive men who have sex with men (HIV+MSM) in India need culturally-relevant interventions to promote safer sex. We tested a multi-level intervention among HIV+MSM that targeted individual, interpersonal, and community factors, based on the Social-Personal and Social Ecological Models. We conducted a 2 × 2 factorial RCT with 119 HIV+MSM randomised to receive either an individual-level intervention (ILI) using motivational interviewing to promote safer sex, a community-level intervention (CLI) to strengthen community norms toward safer sex and reduce stigma among MSM communities, a multi-level intervention combining the individual- and community-level interventions (ILI + CLI), or standard-of-care control. Participants completed pre- and post-intervention assessments of a composite sexual risk score and a process evaluation to assess fidelity and satisfaction. Out of the 119 HIV+MSM, 106 (89.0%) completed pre- and post-intervention assessments. Generalised Estimating Equation models showed that both CLI (Incidence Rate Ratio [IRR] =.67, 95% CI.47 to.96) and ILI + CLI (IRR =.66, 95% CI.48 to.91) groups had a statistically significant decrease in sexual risk compared to the standard-of-care. The interventions had high levels of fidelity and satisfaction. This pilot RCT demonstrated feasibility and potential effectiveness of a multi-level intervention that addresses individual, interpersonal and community-level contributors of sexual risk among HIV+MSM. [ABSTRACT FROM AUTHOR]

Despite high HIV prevalence among transgender women (TGW) in India, there is limited exploration of pre-exposure prophylaxis (PrEP) acceptability. With PrEP licensure pending, we conducted six focus group discussions (FGDs) with diverse TGW (n = 36), and eight key informant interviews with community leaders and physicians, in Mumbai and Chennai. Data were explored using framework analysis guided by the Theoretical Framework of Acceptability. FGD participants' mean age was 26.1 years (SD = 4.8); two-thirds engaged in sex work. TGW reported low PrEP awareness, with moderate acceptability once PrEP was explained. Population-specific facilitators of PrEP acceptability included its perceived effectiveness in the context of challenges to condom use in serodiscordant relationships and forced sex encounters. PrEP was considered especially appropriate for TGW sex workers; however, barriers were anticipated in the context of hierarchical hijra (indigenous trans identity) kinship networks and gurus' (masters) potential negative reactions to PrEP use by their chelas (disciples). Positive attitudes toward high efficacy and potential covert use were tempered by TGW's concerns about high costs and adherence challenges living with parents or primary partners, and TGW sex workers' unpredictable schedules. Anticipated interactions with feminizing hormones, visible side effects, and PrEP-related stigma within TGW communities emerged as opportunity costs. PrEP implementation for TGW in India should promote comprehensive information on side effects and potential interactions with feminizing hormones, provide free or subsidized PrEP, and highlight the advantages of added protection in sex work and forced sexual encounters. Meaningful engagement with TGW kinship networks can encourage positive transgender community norms on PrEP use and mitigate multifaceted stigma. [ABSTRACT FROM AUTHOR]

Available reconstructions of Jurassic global sea level changes differ and are in need of an update. New stratigraphical charts and palaeogeographical developments for a number of large continental blocks or their portions of these (e.g., Germany, India, northeast Africa, northwest Australia, the Russian Platform and western Siberia) reveal regional long-term shoreline shifts (i.e., transgressions and regressions) during the Bajocian Stage (168.3–170.3 Ma). A comparison of these allows to document only a single coherent feature, namely the earliest Bajocian transgression, in the majority of the continental blocks considered. Undoubtedly, this event was triggered by a eustatic rise. However, long-term shoreline shifts were either weak to absent or differed between the blocks during almost the entire Bajocian, thus providing evidence of the apparent stability of global sea level and the importance of regional tectonic activity as a control mechanism on particular transgressions and regressions. Interestingly, it appears that the earliest Bajocian eustatic rise was a constituent of a long-term eustatic pattern; the nature of this event has yet to be fully understood. Generally, the findings presented here are in better agreement with Anthony Hallam's view of Jurassic eustasy and question some other global sea level reconstructions. [ABSTRACT FROM AUTHOR]

Purpose: Students joining medical studies may be motivated by many factors. However, there may also be some factors which may concern them. Although, it can be assumed that those joining medical studies would have largely been influenced positively, how the factors interact in different groups of students has not been studied adequately. Methods: We conducted a questionnaire-based survey in first-year medical students. Besides the demographics and intentions about their future career plans, students rated a list of positively influencing items and a list of negatively affecting items relevant to our context that influenced their decision. We performed factor analysis followed by clustering of study participants. Results: Ninety-seven students participated in the survey which comprised of 59% females with mean age of 18.6 years. The factors extracted were named as 'personal growth factor,' 'professional calling factor,' 'personal concerns factor,' and 'professional concerns factor.' Four distinct clusters of participants differing in their average ratings to each of the above factors were identified. Conclusion: This study provides information on the factors that influence students to join medical studies from an Indian context. The motivational patterns were varied in different sub-groups of students. The data obtained from this study may provide pointers to educators to plan training of students, changes in curricular structure that takes into account the expansion of medical education into specialties and beyond. [ABSTRACT FROM AUTHOR]

Purpose: The study aimed to identify the motivational factors and demographic variables influencing the career preferences of medical students and interns in India. Methods: We conducted a questionnaire-based survey at Christian Medical College, Vellore, India. The participants were 368 of the 460 medical students and interns enrolled at the institution from October 2015 to August 2016. We designed the questionnaire to collect demographic data, students' preferences for career specialties, and the motivational factors influencing them. Then, we analyzed the influence of these factors and demographic variables on career preferences using regression analysis. Results: Of the 368 respondents, 356 (96.7%) expressed their intention to pursue a residency program (known as postgraduate courses in India) after the Bachelor of Medicine and Bachelor of Surgery (MBBS) program, and about two-thirds indicated their preference to do so in India. The specialties most preferred by students were general surgery, general medicine (internal medicine), and pediatrics, while the least preferred were anatomy, obstetrics and gynecology, and community medicine (also known as social and preventive medicine). Factor analysis yielded three motivational factors, which we named 'personal growth,' 'professional growth,' and 'personal satisfaction' based on the items loaded in each. The motivational factors were predicted by demographic variables (gender, geographical background, current stage in the MBBS program, and the presence of relatives in the health professions). Demographic variables and the motivational factors also had significant influences on career preferences. Conclusion: This study provides insights into the motivational factors that influence the career preferences of Indian medical students and interns. A robust longitudinal study would be required to study intra-individual variations in preferences and the persistence of choices. [ABSTRACT FROM AUTHOR]

Microalgae-derived biodiesel has emerged as a promising solution to meet the increasing global demand for carbon-free and environmentally sustainable energy. This study explores the diversity of microalgae across seasons in Kerala, India, to assess their potential for biodiesel production. A total of Ninety marine microalgal isolates were analyzed, revealing Cyanophyceae sp. as the dominant group (67.64%), followed by Bacillariophyceae (22.54%), Chlorophyceae (5.88%), Xanthophyceae (1.96%), and Trebouxiophyceae (1.96%). Microalgae species distribution varied across regions, with Munnakal region exhibiting the highest diversity. Seasonal fluctuations played a significant role, with diversity peaking during pre-monsoon, followed by post-monsoon, summer, and winter. Five isolates with the highest growth (OD values) were identified, and SNMVBTAR007 (285 ± 1.5 mg/L) and SNMVBTAR001 (294 ± 2.0 mg/L) displayed the highest biomass concentration. Lipid analysis revealed SNMVBTAR001 (59%) and SNMVBTAR044 (55%) as having the highest lipid concentrations. Molecular characterization confirmed their identification as Nodosilinea nodulosa. Transesterification of extracted microalgal lipids yielded biodiesel meeting ASTM and EN standards. Fatty acid analysis indicated the presence of desirable fatty acids, particularly oleic acid. Qualitative assessments, including density, acid value, flashpoint, and soap content, aligned with biodiesel standards. Nodosilinea nodulosa SNMVBTAR001, a potential candidate for biodiesel production, with maximum efficiency of 23.10 km/L in an electrical generator. This study underscores the promise of Nodosilinea nodulosa microalgae for sustainable biodiesel production, offering eco-friendly energy solutions and reduced carbon emissions. Further research is needed to optimize cultivation and production techniques for large-scale biodiesel production, contributing to a greener and more sustainable energy future. [Display omitted] • 90 marine microalgae from Kerala, India screened for biodiesel productivity. • Nodosilinea nodulosa SNMVBTAR001 selected for biodiesel production. • Biodiesel production is standardized using ASTM and EN parameters. • Maximum efficiency: 23.10 km/L with 20:80 blend (SNMVBTAR001: diesel) at 4500 J/g. [ABSTRACT FROM AUTHOR]

Topical rectal microbicides (RMs) are a new prevention technology in development that aims to reduce the risk of HIV acquisition from anal sex. We examined RM acceptability among men who have sex with men (MSM) in India. We conducted a qualitative exploratory study guided by a modified Technology Acceptance Model, with 10 focus groups (n = 61) of MSM and 10 key informant interviews. Data were explored using framework analysis. RM acceptability was influenced by technological contexts: perceived usefulness of RMs, perceived ease of use of RM and applicator, and habits around condom and lubricant use; individual and interpersonal contexts: perceived relevance and preferences for product formulation and dosing frequency; and MSM community/social contexts: perceived social approval, RM-related stigma, social support. Implementation of RMs for MSM in India may be supported by multi-level interventions that engage community-based organizations in destigmatizing and distributing RMs, ideally gel-based products that enable on-demand use before sex. [ABSTRACT FROM AUTHOR]

This qualitative study explored the acceptability of HIV pre-exposure prophylaxis (PrEP) among MSM in India, and identified facilitators and barriers to future PrEP uptake. In 2014, we conducted 10 focus groups ( n=61) among a purposive sample of diverse MSM recruited through community-based organizations in Chennai and Mumbai, and 10 key informant interviews with community leaders and health care providers. Participants' mean age was 26.1 years (SD 4.8); 62% completed secondary education, and 42% engaged in sex work. No focus group participants had heard of PrEP, but once explained, most reported they would likely use it. PrEP was alternately perceived as a 'back-up plan', a condom substitute, or a burden with concurrent condom use. Facilitators were potential for covert use, sex without condoms, and anxiety-less sex. Potential barriers emerged around stigma associated with PrEP use, fear of disclosures to one's family, wife, or male steady partner, and being labeled as HIV-positive or promiscuous by peers. Preferences emerged for intermittent rather than daily PrEP use, injectable PrEP, and free or subsidized access through community organizations or government hospitals. Key informants expressed additional concerns about risk compensation, non-adherence, and impact on ART availability for treatment. Demonstration projects are needed in India to support PrEP implementation tailored for at-risk MSM. Educational interventions for MSM should address concerns about PrEP effectiveness, side effects, and mitigate risk compensation. Community engagement may facilitate broad acceptability and challenge stigma around PrEP use. Importantly, provision of free or subsidized PrEP is necessary to making implementation feasible among low socioeconomic status MSM in India. [ABSTRACT FROM AUTHOR]

Background: Informed consent based on comprehension of potential risks and benefits is fundamental to the ethical conduct of clinical research. We explored mental models of candidate HIV vaccines and clinical trials that may impact on the feasibility and ethics of biomedical HIV prevention trials among men who have sex with men (MSM) in India. Methods: A community-based research project was designed and implemented in partnership with communitybased organizations serving MSM in Chennai and Mumbai. We conducted 12 focus groups (n = 68) with diverse MSM and 14 key informant interviews with MSM community leaders/service providers using a semi-structured interview guide to explore knowledge and beliefs about HIV vaccines and clinical trials. Focus groups (60- 90 minutes) and interviews (45-60 minutes) were conducted in participants' native language (Tamil in Chennai; Marathi or Hindi in Mumbai), audio-taped, transcribed and translated into English. We explored focus group and interview data using thematic analysis and a constant comparative method, with a focus on mental models of HIV vaccines and clinical trials. Results: A mental model of HIV vaccine-induced seropositivity as "having HIV" resulted in fears of vaccine-induced infection and HIV stigma. Some participants feared inactivated vaccines might "drink blood" and "come alive". Pervasive preventive misconception was based on a mental model of prevention trials as interventions, overestimation of likely efficacy of candidate vaccines and likelihood of being assigned to the experimental group, with expectations of protective benefits and decreased condom use. Widespread misunderstanding and lack of acceptance of placebo and random assignment supported perceptions of clinical trials as "cheating". Key informants expressed concerns that volunteers from vulnerable Indian communities were being used as "experimental rats" to benefit high-income countries. Conclusions: Evidence-informed interventions that engage with shared mental models among potential trial volunteers, along with policies and funding mechanisms that ensure local access to products that demonstrate efficacy in trials, may support the safe and ethical implementation of HIV vaccine trials in India. [ABSTRACT FROM AUTHOR]

A wind power plant meets so many power quality issues when it is connected to a microgrid. This paper envisages a new power quality conditioner to regulate the supply frequency, to control the power flow, to minimize the current harmonics and to regulate the voltage for a fixed-speed induction-type wind generator. The proposed new power line conditioner is called the universal power line manager (UPLM). The control circuit of the UPLM is the combination of the control system of the unified power quality conditioner, power flow control and a frequency regulator. For these reasons, the compensator proposed here is called the UPLM. The complete system has been developed, analysed and validated by Matlab/Simulink study. Simulation results are presented to confirm that the new approach has a better performance for wind turbine generation. [ABSTRACT FROM PUBLISHER]

A study on the prevalence of common food borne pathogens (Salmonella, Staphylococcus and E. Coli) in chicken meat obtained from wet market in Bangalore under different processing conditions was carried out. Results revealed higher prevalence of Salmonella in the range of 25 to 65 per cent and the level of contamination of meat with Salmonella decreased with increase in sophistication of slaughter facility and that thigh muscle were highly prone for contamination compared to the breast muscle irrespective of the processing condition. Cent percent prevalence of Staphylococcus was observed in outlets with minimum facilities compared to those meat obtained from outlets with better facilities and hygiene. The prevalence of E. Coli followed a similar trend with a range between 42 to 88 per cent indicating the lower hygiene of the meat obtained from the wet market. Lack of hygiene and better facilities have been major cause of poor microbial quality of meat. [ABSTRACT FROM AUTHOR]