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In southern India, forming the Deccan Shiite governments (1098-895 AH / 1687-1489 AD), which was simultaneous with the Safavid reign in Iran, resulted in incremental Iranians’ immigration to this region. Among immigrants, Iranian Shiite physicians, due to their high medical knowledge and considerable skill, along with the support of the Shiite rulers, enhanced their status and settled in areas under the control of those governments, contributing to the festive medical production and developments there. The main objective of this research is to investigate the effect of the Iranian Shiite physicians, who migrated to the Deccan region, on the Shiite governments' medical advancements. The research hypothesis is that the Iranian physicians developed medicine by establishing Dar al-Shifa (medical schools and hospitals) and teaching and authoring medical books in Persian. Moreover, upon the invitation and support of the Adil Shahi, Nizam Shahi, and Qutb Shahi Shiite rulers, they were appointed as special physicians in the court, resulting in the flourishing and advancement of medical sciences in those areas. The research employed a descriptive-analytical research method and collected data by library resources. [ABSTRACT FROM AUTHOR]