1. Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A.
- Author
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Ohkura S, Yamashita M, Ishida T, Babu PG, Koyanagi Y, Yamamoto N, Miura T, and Hayami M
- Subjects
- Adult, Child, DNA, Viral chemistry, Female, Human T-lymphotropic virus 1 isolation & purification, Humans, India, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, Terminal Repeat Sequences genetics, HTLV-I Infections virology, Human T-lymphotropic virus 1 genetics, Polymorphism, Genetic
- Abstract
Seven isolates of human T cell leukemia virus type 1 (HTLV-1) were taken in southern India and phylogenetically analyzed to gain new insights into the origin and dissemination of HTLV-1 in the subcontinent. The new Indian HTLV-1s were found to be members of subgroup A (Transcontinental subgroup) of the Cosmopolitan group. They formed three different clusters (South African/Caribbean, Middle Eastern, and East Asian clusters). These results demonstrate that Indian HTLV-1s are genetically heterogeneous and include the most divergent strain of subgroup A. On the basis of these results, we speculate that subgroup A HTLV- 1s may have been present for thousands of years in India.
- Published
- 2005
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