1. Cause-Specific Mortality in Multiethnic South East Asians With Type 2 Diabetes Mellitus.
- Author
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Liu, Jian-Jun, Choo, Robin W. M., Liu, Sylvia, Gurung, Resham L., Wee, Shiou Liang, and Lim, Su Chi
- Subjects
MORTALITY risk factors ,INSULIN therapy ,CAUSES of death ,GLYCOSYLATED hemoglobin ,TRIGLYCERIDES ,HDL cholesterol ,GLOMERULAR filtration rate ,ALBUMINS ,KRUSKAL-Wallis Test ,CONFIDENCE intervals ,GLYCEMIC control ,SELF-evaluation ,SERUM ,CHEMILUMINESCENCE assay ,ONE-way analysis of variance ,AGE distribution ,SYSTOLIC blood pressure ,CARDIOVASCULAR diseases ,RISK assessment ,TYPE 2 diabetes ,SOUTHEAST Asians ,KIDNEY diseases ,INFECTION ,IMMUNOASSAY ,SURVIVAL analysis (Biometry) ,MASS spectrometry ,DESCRIPTIVE statistics ,CHI-squared test ,DISEASE duration ,RESEARCH funding ,TUMORS ,BLOOD pressure measurement ,DATA analysis software ,BODY mass index ,LONGITUDINAL method ,CREATININE ,PROPORTIONAL hazards models ,DISEASE complications - Abstract
Data on specific causes of mortality in South East Asians with type 2 diabetes mellitus (T2DM) remain scarce. We followed 2061 outpatients with T2DM (Chinese 63%, Malays 20%, and Asian Indians 17%) for an average of 5.5 (standard deviation = 2.9) years and identified 365 death events by data linkage with national death registry. Cardiovascular disease was the main cause of mortality (44%), followed by renal disease (17%), infection (17%), cancer (14%), and others causes (8%). Survival analyses revealed that risks for all-cause and cause-specific mortality vary greatly among ethnic groups. Presence of diabetic kidney disease was an independent risk factor for death attributable to cardiovascular disease, renal disease, and infection, while HbA1c level predicted all major causes of deaths even after accounting for multiple other risk factors. These data reinforce the importance of glycemic control and prevention of diabetic kidney disease for mitigation of mortality burden in multiethnic Asians with T2DM. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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