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Introduction: Women of reproductive age have also been impacted by the significant rise in the prevalence of obesity. A significant predictor of poor outcomes for the health of the mother and the newborn is excessive gestational weight increase. The study was conducted with an objective to study first trimester maternal Body Mass Index and gestational weight gain and their association with maternal and perinatal outcomes. Methodology: This was a prospective observational clinical study conducted in 196 primigravida patients presenting in a tertiary care hospital in central India. BMI of women were recorded during the first trimester and followed up to assesses gestational weight gain. Early pregnancy BMI and gestational weight gain were compared with various feto maternal outcome. Results: The mean of First trimester BMI was 21.3 kg/m2. In Overweight category, 65.2% had high weight gain (WG) while in obese, 26.1% had High WG. Type of delivery and NICU admission rate significantly differ in BMI categories (p <0.05). LSCS rate were higher in overweight and obese category. Preterm babies and post-partum hemorrhage were higher in higher WG categories; however, the difference was non-significant (p>0.05). Conclusion: This study conclude that First trimester underweights and overweight/obesity is associated with higher antenatal, intra-natal and postnatal complications as well as neonatal complications. Caesarian rate and instrumental deliver are also common in First trimester overweight and obese women. Preeclampsia is associated with extreme of First trimester BMI. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to determine the possibility of vertical transmission of COVID-19 from COVID-19 positive mothers to new-borns and the associated factors. Methods: This prospective observational study included a total of 128 antenatal COVID-19-positive women. The present study was conducted in a tertiary-care public hospital in south India. This study evaluated the SARS-CoV-2 positivity rate in neonates born to SARS-CoV-2-positive mothers who tested RT-PCR positive for this virus in their nasopharyngeal swab. During their hospital stay, these neonates' clinical outcomes were also evaluated. Result: Out of 128 pregnancies, 45 study subjects' placenta specimens were COVID-19 positive, 3 neonates and 2 stillborn were RTPCR positive, and 1 neonate's cord blood was also positive. As among 4 stillbirth babies, 2 stillbirth babies were COVID-19 positive therefore there is a statistically significant relationship between stillbirth and vertical transmission (p = 0.007). In the present study, all COVID-19-positive babies were preterm, therefore there is statistically significance between preterm and vertical transmission (p = 0.00). Conclusion: This study demonstrated that there is a possibility of vertical transmission of COVID-19 from COVID-19 positive mothers to new-borns. [ABSTRACT FROM AUTHOR]

Background and objectives: An investigational short course of antibiotics (two doses of Inj. Cefotaxime 1g IV) was compared to the conventional long course antibiotic for the prevention of postoperative infectious complications in patients undergoing elective caesarean sections at a government tertiary care hospital. To Determine which treatment most successfully stops infectious morbidity, like high body temperature, abnormal vaginal discharge, wound induration, wound discharge, and wound gaping. Methods: A prospective interventional study was undertaken by the Obstetrics and Gynaecology Department at Guntur Medical College in Guntur, Andhra Pradesh, India, from February 2022 to January 2023. For this study, 400 participants were randomly assigned to one of two groups. Two hundred individuals make up each group. Participants were chosen based on whether or not they met the inclusion/exclusion criteria. Result: Two groups of 200 patients each participated in the trial. 162 (81%) of the 200 participants were multi-para, while 38 (19%) were primi-para. 30 (15%) of the first group's 200 patients were primi, 9 (4.5%) were multi gravida, and 161 (80.5%) were multiparas who had previously had LSCS but chose to have another one. Its P value is 0.6. Thirty-six women experienced wound induration, 15 (7.4%) in Group 1 and 21 (10.6%) in Group 2. p=0.09 indicated no statistical significance. Serous wound leakage occurred in 12 (6%) group 1 patients and 15 (7.5%) group 2 patients. 41 (10.25%) of 400 patients had pus discharge, 22 (11%) from Group 1 and 19 (9.5%) from Group 2. Both groups' p values are insignificant. Conclusion: This study found that short-term antibiotics are as effective as long-term ones. Both groups had similar febrile morbidity, wound induration, serous and purulent wound discharge, wound gaping, and abnormal vaginal discharge. Lower-strength antibiotics are increasingly relevant due to antibiotic resistance. The short regimen is cheaper than the extended one since it uses less antibiotics. The short-course antibiotic is safe, effective, convenient, and manpower-saving. Thus, preventing irregular drug administration and replacing the three days of intravenous antibiotics followed by oral antibiotics used in tertiary government centres. [ABSTRACT FROM AUTHOR]

Rising in the rates of C-section deliveries worldwide is a major public health concern. According to WHO, C-section rate continues to rise globally, accounting for more than 1 in 5(21%) childbirths. There is lack of evidence supporting the maternal and neonatal benefits with the increasing C-section rates. Robson's Ten Group Classification system (RTGCS) serves as an initial structure with which caesarean section rates can be analyzed and allow us to bring changes in clinical practice. The objective of the current study was to audit C-section rate using Robson's Ten Group Classification System in our tertiary care hospital, and to identify the main contributors of each subgroup to overall Csection rate. This was a cross-sectional study conducted at out tertiary care center, Karpaga Vinayaga Institute of Medical Sciences and Research Centre (KIMS&RC), Madhuranthagam, Tamil Nadu, India during the period of January 2019 to December 2021. The study was conducted by reviewing the hospital record for analyzing the C-sections performed during the above-mentioned period. The study population include the pregnant women who underwent Csections in our hospital during the specified period. The 401 women who underwent C-section were classified in Robson's Ten group classification system, 45% women in Group 5 and it contributed to the maximum number of the total C-section rates. The second highest contributor was Group 1 and Group 2 contributing to 41% of the overall C-section rates. The Robson's Ten group classification system provides a useful framework for auditing C-section rates. Regular audits and standardization of indication of C-section will help in reducing the C-section rate in future. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to examine how the SARS-CoV-2 infection affects antenatal women and newborn babies in terms of symptoms, complications, and outcomes. Methods: A total of 128 antenatal women were included in this prospective single-center observational study. The present study was conducted in a tertiary-level public hospital in Kerala. The presence of SARS-CoV-2 was detected by running a real-time PCR using the extracted RNA using an appropriate PCR kit (SeegenAllplexTM 2019-nCoV Assay). Result: Out of 128 COVID-19-positive antenatal women, RT-PCR was positive for 57.8% of them, followed by antigen positive for 34.4% and TrueNat for 7.1%. The Mean ±SD duration of COVID positivity from delivery was 8.45±5.1 days and the Mean ±SD CRP was 3.15±6.2 mg/dl, Mean ±SD FERRITIN was 61.8±98.2 mg/l and the Mean ±SD D DIMER was 2.09±1.4 mg/l. Seven study subjects were transferred to the intensive care unit (ICU), 5 were given oxygen support, 3 were given NIV assistance with oxygen, and one was transferred on mechanical ventilation due to a severe complication. Out of 128 COVID-positive study subjects, the majority of them didn't have any post-partum complications. 19 study subjects experienced complications such as PPH (10 study subjects), sepsis, and maternal near-miss (4 study subjects), and one study subject died due to thromboembolism. Conclusion: The study demonstrated that LSCS was more in COVID pregnant women. However, the majority of the COVID-positive pregnant women didn't require ICU admission. Further, the study found that the majority of the neonates were COVID-negative and healthy. [ABSTRACT FROM AUTHOR]