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Background: Diagnostic criterion for abnormal glucose tolerance (AGT) in pregnancy is still under debate. This study aims to see the diagnostic efficiency of Diabetes in Pregnancy Study Group of India (DIPSI) criterion in context to World Health Organization (WHO) 2013 criterion for detection of AGT in pregnancy. Methods: Pregnant mothers (n = 231; age, 26.07 ± 5.21 years; body mass index (BMI), 25.00 ± 4.09 kg/m2; mean ± SD) were screened for AGT including gestational diabetes mellitus (GDM) and diabetes in pregnancy (DIP) from July 2016 to July 2017 in the "GDM Clinic" of BSMMU following WHO 2013 and DIPSI protocol with an interval of 3–5 days in between. Out of 231 mothers, 204 completed both procedures. Diagnostic efficiency of DIPSI criterion was assessed in the light of WHO 2013 criterion. Results: Out of 204 mothers, 61 (29.9%) had AGT (GDM = 55, DIP = 6) according to WHO 2013 criterion whereas only 36 (17.6%) had AGT (GDM = 33, DIP = 3) by DIPSI criterion. Among participants, age (25.50 ± 5.11 vs. 27.39 ± 5.28, p = 0.018) and BMI (24.50 ± 3.92 vs. 26.31 ± 4.41, p = 0.003) were significantly higher in AGT group than the group with normal glucose tolerance (NGT).Holding WHO 2013 criterion as gold standard, specificity of DIPSI criterion was very high (93.70%), but sensitivity was relatively low (44.26%). There was a fair agreement between the two criteria (kappa = 0.43; p < 0.001). The 2-h glucose values in same subjects were found to be lower when tested for DIPSI criterion protocol in comparison to that WHO 2013 protocol. Conclusion: DIPSI criterion seems to be less sensitive in context to WHO 2013 criterion for detection of AGT in pregnancy. [ABSTRACT FROM AUTHOR]