62 results on '"Infections epidemiology"'
Search Results
2. High burden of infections in Indian patients with Idiopathic Inflammatory Myopathy: validation of observations from the MyoCite dataset.
- Author
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Chatterjee R, Mehta P, Agarwal V, and Gupta L
- Subjects
- Adolescent, Adult, Databases, Factual, Female, Glucocorticoids therapeutic use, Humans, India, Infections etiology, Male, Middle Aged, Prednisone therapeutic use, Prevalence, Retrospective Studies, Risk Factors, Survival Rate, Young Adult, Glucocorticoids adverse effects, Infections epidemiology, Myositis epidemiology, Prednisone adverse effects
- Abstract
Objective: To determine the prevalence, profile and predictors of infections in an Indian cohort with idiopathic inflammatory myopathies (IIM)., Methods: We reviewed the records of a retrospective cohort with IIM enrolled from consecutive patients being followed up in the clinic, and these constituted the observation cohort. A newly diagnosed inception cohort with IIM were followed prospectively as the validation cohort for confirmation of observations and comparison with the observation cohort., Results: Among the 68 patients in the observation cohort (average age 33.4 years, female:male 4.2:1), 37 (54.4%) experienced 54 infections between them; of these 54 infections, 21 (38.8%) were major and recurrent infections and they occurred in 11 patients (16.17%) over 3.08 years. Tuberculosis was the most common infection (12, 22.2%), with a predominance of extrapulmonary forms. Serum protein [odds ratio (OR) 0.44], platelets (0.44) at disease onset and daily steroid dose (1.04) predicted major infections on multivariate analysis. A higher daily dose of steroids at first infection correlated with number of recurrent infections. The infection-free 1-year survival was 73.8%.Of the 70 patients in the validation cohort (average age 35.7 years, female:male 3.7:1), 3 had myositis attributed to an infection. A similar proportion of the cohort experienced infections (22, 33.3%) with similar number of major (10, 45.4%) and recurrent (4, 18%) infections being recorded. The most common infection was community-acquired pneumonia, followed by tuberculosis, with serum albumin (OR 0.25) at disease onset being the only predictor. The one-year infection-free survival rate was 64.7%. Those who had a major infection had increased mortality at 1 year, with a survival rate of 60%, compared with 89.09% in those without.In both cohorts, a daily prednisone dose >6.25 mg predisposed to major infections., Conclusion: Major and recurrent infections are common in Indian IIM patients and confer higher risk for future infections and lower survival. Respiratory and atypical bacterial infections such as tuberculosis occur throughout the disease course., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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3. Histopathological evaluation of cutaneous reactions to tattoos: Study at a tertiary care center.
- Author
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Agarwal P, Jagati A, Mehta R, Vadher P, Rathod S, and Bodar P
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- Adolescent, Adult, Female, Granuloma diagnosis, Granuloma epidemiology, Granuloma etiology, Humans, Hypersensitivity diagnosis, Hypersensitivity epidemiology, Hypersensitivity etiology, Hypersensitivity prevention & control, India epidemiology, Infections diagnosis, Infections epidemiology, Infections etiology, Ink, Lichenoid Eruptions diagnosis, Lichenoid Eruptions epidemiology, Lichenoid Eruptions etiology, Male, Neoplasms diagnosis, Neoplasms epidemiology, Neoplasms etiology, Prevalence, Prospective Studies, Skin Diseases epidemiology, Tattooing legislation & jurisprudence, Tattooing statistics & numerical data, Tertiary Care Centers, Young Adult, Biopsy, Needle methods, Skin Diseases etiology, Skin Diseases pathology, Tattooing adverse effects
- Abstract
Background: Tattooing has been around for many years and is becoming an increasingly common fashion trend. As there are often few regulatory laws regarding the practice, an increase in the incidence of cutaneous reactions to tattoo inks is noted. These include allergic reactions, granulomatous dermatitis, infections, lichenoid dermatoses, and sometimes malignancy. The present study examines the histopathological changes seen in patients with cutaneous reactions to tattoo ink., Method: A prospective observational study was conducted over 18 months in the dermatology clinic of a tertiary care center in western India. The study population included 22 patients with cutaneous reactions over the tattoos. Punch biopsy specimens were sent to study the pattern of histopathological response., Results: All 22 patients studied were between the ages of 17 and 35 years. The mean duration of development of reaction was 8.1 months. Most of the reactions were seen in black ink tattoos performed by amateurs. Perivascular and spongiotic dermatitis suggestive of allergic response was the most common feature on histopathology. Granulomatous response and lichenoid response were seen in five and three biopsies, respectively., Conclusion: Legalization is needed for this practice to prevent tattoo reactions. Histopathological evaluation is important as tattoo reactions may be associated with skin infections and malignancies., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2021
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4. Outcomes in adolescent and young adult acute lymphoblastic leukaemia: a report from the Indian Acute Leukaemia Research Database (INwARD) of the Hematology Cancer Consortium (HCC).
- Author
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Ganesan P, Jain H, Bagal B, Subramanian PG, George B, Korula A, Mehra N, Kalaiyarasi JP, Bhurani D, Agrawal N, Ahmed R, Kayal S, Bhattacharyya J, Yanamandra U, Kumar S, Philip CC, John MJ, Nadaraj A, Karunamurthy O, Lakshmanan J, Mathews V, and Sengar M
- Subjects
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols economics, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Databases, Factual, Disease Progression, Follow-Up Studies, Hematology standards, Humans, India epidemiology, Infections epidemiology, Infections mortality, Medication Adherence psychology, Medication Adherence statistics & numerical data, Neoplasm, Residual epidemiology, Outcome Assessment, Health Care, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology, Retrospective Studies, Socioeconomic Factors, Survival Analysis, Young Adult, Antineoplastic Combined Chemotherapy Protocols adverse effects, Hematology statistics & numerical data, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality
- Published
- 2021
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5. Nutritional status in children with acute lymphoblastic leukemia, and its correlation with severe infection.
- Author
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Sonowal R and Gupta V
- Subjects
- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, India epidemiology, Infant, Infections epidemiology, Infections etiology, Male, Prognosis, Retrospective Studies, Infections pathology, Malnutrition physiopathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
- Abstract
Background: Undernutrition is a common childhood problem in India which may contribute to higher risk of infection and lower survival rate in children with acute lymphoblastic leukemia (ALL)., Methods: In our study, we retrospectively included patients of age group 1-15 years who were treated for ALL and survived induction. Data on weight, height and serum albumin levels recorded at the time of diagnosis of the patients were used in this study. For defining acute undernutrition we used weight-for-height, weight-for-age criteria for children ≤5 years and body mass index for age >5 years. We correlated nutritional status of the patients with severe infection and mortality percentage., Results: There were 101 patients with male:female ratio of 2.4:1. Forty-four children were ≤5 years and 57 children were >5 years of age. It was found that 74 children had B-cell ALL and 17 children had T-cell ALL; 54 patients were stratified as high-risk and 47 as standard-risk. In all, 52.5% patients had acute undernutrition at diagnosis. In ALL patients with acute undernutrition, severe infection was found to be 10.8% higher than ALL patients with normal nutrition which was statistically insignificant. Male children and children with serum albumin level <3.5 g/dL in the acute undernutrition group had higher risk of infection. Mortality percentage of patients with baseline acute undernutrition was found to be higher by 11% than normal nutrition group (P-value = 0.21)., Conclusion: Our study highlights the magnitude of undernutrition at diagnosis in ALL patients in a tertiary care centre. It also correlates nutritional status with severe infection and mortality in follow-up., Competing Interests: None
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- 2021
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6. Prevalence of Anemia in View of Socio-demographic and Health Status of Adolescent Girls Enrolled in Government School at Border-belt of Indian Punjab.
- Author
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Dhillon PK, Kumar B, and Verma HK
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- Adolescent, Cross-Sectional Studies, Female, Hemoglobins analysis, Humans, Hygiene, India epidemiology, Infections epidemiology, Prevalence, Social Class, Anemia epidemiology, Health Status, Socioeconomic Factors
- Abstract
Poor socio-demographic and health status are considered key factors for prevalence of anemia in school-going adolescent girls in developing countries. A cross-sectional study was conducted (2019-2020) on 32 adolescent girls, randomly selected from 9
th , 10th , 11th , and 12th standards at Government School, Harike Pattan to assess magnitude of anemia and its associated factors. Hemoglobin level of adolescent girls was assessed using cyanmethaemoglobin method. Subsequently, adolescent girls were interviewed about their hygiene and health status through a pre-structured interview schedule. Collected data were analyzed by applying One-way ANOVA (analysis of variance) with Tukey's post-hoc test and Chi-square test to investigate prevalence of anemia and its association ( p < .05) with various independent variables, correspondingly. Research findings indicated a high (100%) overall prevalence of anemia among adolescent girls, with mild, moderate, and severe anemia in 28, 59, and 13% of total adolescent girls, respectively, reflect the burden of this nutritional turmoil at a great extent. Low mean hemoglobin level (9.9 g/dl) was significantly ( p < .05) associated with low socio-economic status, schedule caste, long duration of menstruation, poor personal and food hygiene profile, and infections among adolescent girls. Awareness on factors enhancing iron bio-accessibility among adolescent girls is highly recommended.- Published
- 2021
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7. Risk factors for symptoms of infection and microbial carriage among French medical students abroad.
- Author
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Dao TL, Canard N, Hoang VT, Ly TDA, Drali T, Ninove L, Fenollar F, Raoult D, Parola P, Marty P, and Gautret P
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- Actinobacteria, Adult, Diarrhea epidemiology, Diarrhea microbiology, Escherichia coli, Female, France epidemiology, Humans, India, Male, Risk Factors, Senegal, Vietnam, Young Adult, Carrier State epidemiology, Infections epidemiology, Students, Medical, Travel
- Abstract
Objectives: To investigate symptoms of infections and their risk factors among French medical students undertaking an internship abroad., Methods: Clinical follow up, and qPCR-based respiratory, gastrointestinal, and vaginal pathogen carriages were prospectively assessed pre-travel and post-travel, in a cohort of medical students departing from Marseille, France., Results: 293 students were included. 63.5%, 35.8%, and 3.6% of students reported gastrointestinal, respiratory, and vaginal symptoms, respectively. The acquisition rate of Enteroaggregative Escherichia coli and Enteropathogenic E. coli was 40.9% and 18.6%, respectively. A significant increase was observed for rhinovirus and Streptococcus pneumoniae by comparing the prevalence of pathogens in pre-travel and post-travel samples. Gardnerella vaginalis and Atopobium vaginae acquisition rates were 12.9% and 13.9%, respectively. Being female, primarily traveling to Vietnam, and living in basic accommodation conditions were independent risk factors for reporting respiratory symptoms. Students reporting respiratory symptoms were three times more likely to acquire S. pneumoniae. Traveling primarily to north India and Senegal were independent risk factors for diarrhea., Conclusion: This study makes it possible to identify the leading infectious diseases linked to travel in a group of French medical students undertaking an internship abroad and the risk factors on which to base targeting students for reinforced pre-travel advice., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2020
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8. Infections and diabetes: Risks and mitigation with reference to India.
- Author
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Unnikrishnan R and Misra A
- Subjects
- Adaptive Immunity immunology, Blood Glucose metabolism, COVID-19 immunology, COVID-19 metabolism, Diabetes Mellitus immunology, Diabetes Mellitus metabolism, Glycemic Control, Humans, Immunity, Innate immunology, India epidemiology, Infections epidemiology, Infections immunology, Infections metabolism, Reproductive Tract Infections epidemiology, Reproductive Tract Infections immunology, Reproductive Tract Infections metabolism, Respiratory Tract Infections epidemiology, Respiratory Tract Infections immunology, Respiratory Tract Infections metabolism, Risk Factors, SARS-CoV-2, Severity of Illness Index, Skin Diseases, Bacterial epidemiology, Skin Diseases, Bacterial immunology, Skin Diseases, Bacterial metabolism, Soft Tissue Infections epidemiology, Soft Tissue Infections immunology, Soft Tissue Infections metabolism, Tuberculosis, Pulmonary immunology, Tuberculosis, Pulmonary metabolism, Urinary Tract Infections epidemiology, Urinary Tract Infections immunology, Urinary Tract Infections metabolism, COVID-19 epidemiology, Diabetes Mellitus epidemiology, Tuberculosis, Pulmonary epidemiology
- Abstract
Background and Aims: The link between diabetes and increased risk of infectious disease has long been recognized, but has re-entered sharp focus following the COVID-19 pandemic., Methods: A literature search was conducted in PubMed for articles in English on diabetes and infection., Results: Diabetes predisposes to infections through alterations in innate and acquired immune defenses. Outcomes of infection are worse in people with uncontrolled diabetes, and infection can worsen hyperglycemia in hitherto well controlled diabetes (bidirectional relationship). Diabetes does not increase the risk of infection with COVID-19 per se, but predisposes to severe disease and poor outcomes. COVID-19 has also been linked to deterioration of glycemic control as well as new-onset diabetes., Conclusions: Clinicians caring for people with diabetes should be aware of the increased risk of infections in this population, as well as the possibility of worsening hyperglycemia. A holistic approach with frequent monitoring of blood glucose levels and appropriate titration of medications, along with close attention to nutritional status, is essential to ensure the best possible outcomes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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9. Hemophagocytic Lymphohistiocytosis in Children: Clinical Profile and Outcome.
- Author
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Simon AC, Delhi Kumar CG, Basu D, and Ramesh Kumar R
- Subjects
- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Incidence, India epidemiology, Infant, Infections epidemiology, Infections etiology, Male, Prognosis, Prospective Studies, Retrospective Studies, Risk Factors, Survival Rate, Infections mortality, Lymphohistiocytosis, Hemophagocytic complications
- Abstract
Objectives: The objectives of this study were to describe the clinical and etiologic profile and outcomes of children with hemophagocytic lymphohistiocytosis (HLH) in a tertiary care hospital in South India., Methods: This is a combined 2-year prospective (2017 to 2018) and 5-year retrospective (2012 to 2016) descriptive study in which children from birth to 18 years who satisfied the HLH-2004 diagnostic criteria were included. Case details from patient records were analyzed., Results: Fifty-three cases were enrolled of which 20 were prospective and 33 were retrospective. Fever, hepatomegaly, anemia, and hyperferritinemia were the common presentations. Infectious triggers were found in 33 (62%) cases. Five cases were secondary to rheumatic diseases, and 8 were primary HLH. Bacterial (14 cases) followed by viral infections (10 cases) were the leading triggers. Scrub typhus (6 cases) and dengue (4 cases) were the most common infectious agents. Major complications include febrile neutropenia (38%) and multiorgan dysfunction (26%). One child developed secondary malignancy. The most frequently used immunosuppressive drug for the treatment of HLH was steroid (70%), while 28% of cases recovered with only supportive therapy. The overall mortality was 41%., Conclusions: Infections were the most common triggers for HLH of which tropical infectious agents constituted the majority. Treatment with steroids alone or regimens without cytotoxic drugs may result in resolution of secondary HLH with mild to moderate disease activity. Without stem cell transplant, primary HLH has a high mortality rate.
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- 2020
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10. Hexavalent Vaccines in India: Current Status.
- Author
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Chitkara AJ, Parikh R, Mihalyi A, and Kolhapure S
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- Communicable Disease Control methods, Communicable Disease Control organization & administration, Humans, Immunization Schedule, India epidemiology, Infant, Infant, Newborn, Vaccines, Acellular classification, Vaccines, Acellular pharmacology, Infections classification, Infections epidemiology, Vaccination methods, Vaccination statistics & numerical data, Vaccines, Combined classification, Vaccines, Combined pharmacology
- Abstract
Hexavalent vaccines containing diphtheria, tetanus, pertussis, Haemophilus influenzae type b, poliomyelitis, and hepatitis B virus antigens have the potential to be used for the primary series in India (6, 10, 14 weeks of age) and the toddler booster dose. Three hexavalent vaccines are available in India: DTwP-Hib/HepB-IPV (wP-hexa), DTaP-IPV-HB-PRP~T(2aP-hexa), and DTaP-HBV-IPV/Hib (3aP-hexa). In the three published phase-3 Indian studies, pertussis 'vaccine response' rates 1 month after a 6-10-14-week primary series were 68.4-75.7% for wP-hexa, 93.8-99.3% for 2aP-hexa, and 97.0-100% for 3aP-hexa; seroprotection rates for the other five antigens were 88.2-100%, 49.6-100%, and 98.6-100%, respectively. Studies outside India show: good immunogenicity/safety after boosting dosing; immune persistence to age 4.5 years (2aP-hexa), 7-9 years (3aP-hexa) (all antigens), and 9-10 and 14-15 years, respectively (hepatitis B); and successful co-administration with other vaccines. Hexavalent vaccines could reduce the number of injections, simplify vaccination schedules, and improve compliance.
- Published
- 2019
11. Incidence and risk factors for major infections in hospitalized children with nephrotic syndrome.
- Author
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Kumar M, Ghunawat J, Saikia D, and Manchanda V
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- Albumins analysis, Cellulitis complications, Cellulitis epidemiology, Cellulitis microbiology, Child, Child, Preschool, Female, Hospitalization trends, Humans, Immunosuppressive Agents adverse effects, Incidence, India epidemiology, Infections etiology, Male, Multiple Organ Failure epidemiology, Multiple Organ Failure mortality, Nephrotic Syndrome diagnosis, Peritonitis blood, Peritonitis complications, Peritonitis epidemiology, Peritonitis microbiology, Pneumonia complications, Pneumonia epidemiology, Pneumonia microbiology, Prospective Studies, Risk Factors, Sepsis epidemiology, Sepsis mortality, Streptococcus pneumoniae isolation & purification, Urinary Tract Infections complications, Urinary Tract Infections epidemiology, Urinary Tract Infections microbiology, Hospitalization statistics & numerical data, Infections epidemiology, Infections mortality, Nephrotic Syndrome complications
- Abstract
Introduction: Children with nephrotic syndrome are at increased risk of infections because of disease status itself and use of various immunosuppressive agents. In majority, infections trigger relapses requiring hospitalization with increased risk of morbidity and mortality. This study aimed to determine the incidence, spectrum, and risk factors for major infections in hospitalized children with nephrotic syndrome., Methods: All consecutive hospitalized children between 1-12 years of age with nephrotic syndrome were enrolled in the study. Children with acute nephritis, secondary nephrotic syndrome as well as those admitted for diagnostic renal biopsy and intravenous cyclophosphamide or rituximab infusion were excluded., Results: A total of 148 children with 162 admissions were enrolled. Incidence of major infections in hospitalized children with nephrotic syndrome was 43.8%. Peritonitis was the commonest infection (24%), followed by pneumonia (18%), urinary tract infection (15%), and cellulitis (14%), contributing with two thirds of major infections. Streptococcus pneumoniae (n = 9) was the predominant organism isolated in children with peritonitis and pneumonia. On logistic regression analysis, serum albumin < 1.5gm/dL was the only independent risk factor for all infections (OR 2.6; 95% CI, 1.2-6; p = 0.01), especially for peritonitis (OR 29; 95% CI, 3-270; p = 0.003). There were four deaths (2.5%) in our study, all due to sepsis and multiorgan failure., Conclusions: Infection remains an important cause of morbidity and mortality in children with nephrotic syndrome. As Pneumococcus was the most prevalent cause of infection in those children, attention should be paid to the pneumococcal immunization in children with nephrotic syndrome.
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- 2019
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12. Incidence of infection other than tuberculosis in patients with autoimmune rheumatic diseases treated with bDMARDs: a real-time clinical experience from India.
- Author
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Chandrashekara S, Shobha V, Rao V, Desai A, Jois R, Dharmanand BG, Kumar S, Kumar P, Dharmapalaiah C, Mahendranath KM, Prasad S, Daware MA, Singh Y, Karjigi U, Nagaraj S, and Anupama KR
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Arthritis, Psoriatic drug therapy, Arthritis, Rheumatoid drug therapy, Cross-Sectional Studies, Drug Therapy, Combination, Female, Humans, Incidence, India epidemiology, Lupus Erythematosus, Systemic drug therapy, Male, Middle Aged, Retrospective Studies, Spondylarthropathies drug therapy, Young Adult, Antirheumatic Agents therapeutic use, Autoimmune Diseases drug therapy, Biological Factors therapeutic use, Infections epidemiology, Rheumatic Diseases drug therapy, Tumor Necrosis Factor Inhibitors therapeutic use
- Abstract
Biologic disease-modifying anti-rheumatic drugs (bDMARD) have transformed the treatment paradigm of chronic autoimmune rheumatic diseases (ARDs), but they are often associated with adverse drug reactions. The present study evaluated the frequency, characteristics and type of infections, other than tuberculosis (TB), in ARD patients receiving bDMARDs. The multicentre, cross-sectional, retrospective, observational study was conducted across 12 centers in Karnataka, India, between January to August 2016. The study included patients receiving bDMARD therapy for various ARDs. Outcome variables considered were any infection, minor infections and major infections, other than TB. Clinical variables were compared between infection and no infection group, and the increase in the likelihood of infection with respect to various clinical variables was assessed. The study involved 209 subjects with a median (range) age of 41 (16-84) years and male to female ratio of 0.97:1. A total of 29 (13.88%) subjects developed infection following bDMARD therapy, out of whom a majority had minor infection (n = 26). The likelihood of developing any infection was noted to be more in subjects receiving anti-TNF (golimumab, P = 0.03) and those on three or more conventional synthetic (cs) DMARDs (P < 0.01). Infection risk was higher in patients with systemic lupus erythematosus (P = 0.04), other connective tissue disease (P < 0.01) and in patients with comorbidities (P = 0.13). The risk of infection was associated with the use of anti-TNF therapy and more than three csDMARDs, co morbidities and Adds such as systemic lupus erythematosus and connective tissue disease.
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- 2019
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13. Risk Factors for Microbiologically-documented Infections, Mortality and Prolonged Hospital Stay in Children with Febrile Neutropenia.
- Author
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Das A, Trehan A, and Bansal D
- Subjects
- Anti-Bacterial Agents therapeutic use, Child, Child Mortality, Child, Preschool, Cross-Sectional Studies, Febrile Neutropenia microbiology, Febrile Neutropenia mortality, Female, Humans, India, Infant, Infections etiology, Infections mortality, Male, Prospective Studies, Risk Factors, Febrile Neutropenia complications, Infections epidemiology, Length of Stay statistics & numerical data
- Abstract
Objective: To analyze the risk factors for microbiologically documented infection, mortality and hospital stay more than 5 days in children with febrile neutropenia., Design: Cross-sectional study (July 2013-September 2014)., Setting: Government-run, tertiary-care, university hospital in Chandigarh, Northern India., Participants: 414 episodes in 264 children aged <12 years, not undergoing stem-cell transplantation., Outcome Measures: Predictors for 'high-risk' febrile neutropenia., Results: Microbiologically-documented infections were observed in 82 children (19.8%); bacterial 14.2%, fungal 4.3%, polymicrobial 9.7%. Complications were documented in 109 (26%) children. 43 (10.3%) died: 8 due to fungal and 35 due to bacterial sepsis. Children admitted within 7 days of the last chemotherapy (P<0.01) and having a non-upper respiratory focus of infection (P<0.02) were at risk of developing microbiologically-documented infections and death. Platelet count <20000/uL (P=0.03) was an additional predictor for microbiologically-documented infections, while albumin <2.5 g/dL (P=0.04) and C-reactive protein >90 mg/L (P=0.02) were risk factors predicting mortality. The median (IQR) duration of hospital stay was 5 (3,8) days. Hospital stay <5 days was seen in 144 (35%) children. Children with acute myeloid leukaemia (P<0.01) and admitted within 7 days of chemotherapy (P=0.02) were likely to have a prolonged hospital stay >5 days., Conclusions: Febrile neutropenic children admitted within 7 days of completion of chemotherapy, those with a non-upper respiratory focus of infection, CRP >90 mg/dL, platelet <20000/uL and albumin <2.5 g/dL need to be considered as 'high risk' for complications and mortality.
- Published
- 2018
14. "Near-Miss obstetric events" and its clinico-social correlates in a secondary referral unit of Burdwan District in West Bengal.
- Author
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Kumar R and Tewari A
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- Adult, Age Factors, Anemia epidemiology, Cross-Sectional Studies, Female, Humans, Hypertension epidemiology, India, Infections epidemiology, Maternal Mortality, Middle Aged, Near Miss, Healthcare, Postpartum Hemorrhage epidemiology, Pregnancy, Pregnancy Complications epidemiology, Socioeconomic Factors, World Health Organization, Young Adult, Obstetric Labor Complications epidemiology
- Abstract
Near-miss obstetric events (NMEs) refers to the situations where women experience severe, life-threatening obstetric complications during pregnancy, delivery, or postpregnancy (up to 42 days) which they survive either by chance or because they receive good care at a facility. A cross-sectional study was conducted from May to June 2016 at the subdivisional hospital of West Bengal. The WHO near-miss criteria were followed for case identification. Data were collected by interview and record review. No maternal deaths were reported during data collection period; however, the frequency of NMEs was quite high (38%). Maternal near-miss ratio was 379.51/1000 live births, and maternal mortality index was 0%. Higher age group, below poverty line status, term pregnancy, and higher gravid and higher parity significantly favored the occurrence of NMEs, while ANC registration and Iron and Folic Acid consumption were significantly protective against it. Early identification of risk factors for NMEs and prompt initiation of treatment plays a critical role in the management of NMEs., Competing Interests: There are no conflicts of interest
- Published
- 2018
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15. Assessing clinical sequelae of untreated caries among 5-, 12-, and 15-year-old school children in ambala district: A cross-sectional study.
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Sudan J, Sogi GM, and Veeresha LK
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- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, DMF Index, Dental Caries complications, Female, Humans, India epidemiology, Infections epidemiology, Male, Mouth Diseases epidemiology, Prevalence, Dental Caries epidemiology
- Abstract
Background: Dental caries is a public health problem globally, especially in children. Thus, it is important to quantify its clinical consequences in terms of its prevalence and severity., Aim: This study aims to assess the prevalence and severity of oral conditions linked with untreated dental caries using pulp involvement, ulceration, fistula, abscess (pufa/PUFA) index in 5-, 12-, and 15-year-old school children in Ambala district., Settings and Design: This cross-sectional study was conducted among 433 school children of 5-, 12-, and 15-year-old age group in Ambala district., Materials and Methods: In the present study, participants were recruited from randomly selected schools and were examined according to pufa/PUFA index and Oral Health Surveys Dentition Status., Statistical Analysis Used: Data were analyzed using SPSS Software Version 20.0 (Chicago, USA). The statistical significance was determined by Chi-square test, and level of significance was set at P < 0.05. Correlation analysis was expressed in terms of Pearson's correlation coefficient (r)., Results: Caries prevalence was reported to be 58.4% while the prevalence of odontogenic infections was 45.3%. Untreated caries pufa/PUFA ratio among 5, 12, and 15 years old was 44.58%, 38.33%, and 36.18%, respectively. The care index among 5, 12, and 15 years old was 0, 3.31%, and 36.18% emphasizing the lack of utilization of dental services by school children., Conclusions: The use of PUFA/pufa index as an adjunct to the classical caries indices can address the neglected problem of untreated caries and its consequences., Competing Interests: There are no conflicts of interest
- Published
- 2018
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16. Combating antimicrobial resistance in India: Technical challenges & opportunities.
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Bhatia R and Walia K
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- Humans, India epidemiology, Infections microbiology, Drug Resistance, Bacterial, Health Knowledge, Attitudes, Practice, Infections epidemiology
- Abstract
Competing Interests: None
- Published
- 2017
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17. Serosurvey of Malsoor virus among Rousettus leschenaulti bat & human population residing nearby Robber's cave, Mahabaleshwar, Maharashtra, India.
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Yadav P, Deoshatwar A, Shete A, Tandale B, Patil D, Dalal S, and Mourya D
- Subjects
- Adolescent, Aged, Animals, Betacoronavirus genetics, Betacoronavirus pathogenicity, Child, Chiroptera virology, Female, Humans, India epidemiology, Infections epidemiology, Infections genetics, Male, Phlebovirus genetics, Phlebovirus pathogenicity, Betacoronavirus isolation & purification, Infections transmission, Infections virology, Phlebovirus isolation & purification
- Abstract
Competing Interests: None
- Published
- 2017
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18. Emerging trends and patterns of self-reported morbidity in India: Evidence from three rounds of national sample survey.
- Author
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Paul K and Singh J
- Subjects
- Adolescent, Adult, Aged, Cardiovascular Diseases epidemiology, Female, Health Promotion, Health Services Accessibility, Humans, India epidemiology, Infections epidemiology, Male, Middle Aged, Noncommunicable Diseases epidemiology, Public Health, Rural Population, Self Report, Urban Population, Health Surveys statistics & numerical data, Prevalence
- Abstract
Background: India is rapidly undergoing an epidemiological transition with a sudden change in the disease profile of its population. It is important to understand the changing nature of the burden of disease across the states of India for adequate policy intervention., Methods: We analyzed the trend and pattern of self-reported morbidity across states of India using three rounds of (52nd, 60th and 71st) National Sample Survey Organization (NSSO) data. Descriptive analysis was carried out to understand the prevalence of self-reported morbidity variation over a period of two decades (1995-2014) and multivariate analysis was performed to identify the significant determinants of various types of self-reported morbidities., Results: The results indicated an increasing trend of infectious disease, Cardio Vascular Diseases (CVDs) and Non-Communicable Diseases (NCDs) over the last two decades (1995-2014). CVDs increased by a whopping eight-fold and the NCDs increased by three times during this period. A higher prevalence of self-reported morbidity was observed among the elderly and female, particularly in the urban locality. The growing incidence of CVDs and NCDs, especially among the elderly were reported from Kerala, Tamil Nadu, Punjab and West Bengal., Conclusions: The already constrained public health system in India is likely to face serious challenges with a double burden of communicable and non-communicable diseases. An effective and responsive public health system needs to be in place to make health care services available for NCDs and CVDs at the primary level. In order to ameliorate caregiving, the involvement of family will be critical. Informing the people inculcate healthy habits may be an effective health promotion measure.
- Published
- 2017
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19. Analysis of beta-lactamases, bla NDM-1 phylogeny & plasmid replicons in multidrug-resistant Klebsiella spp. from a tertiary care centre in south India.
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Nithya N, Remitha R, Jayasree PR, Faisal M, and Manish Kumar PR
- Subjects
- Humans, India epidemiology, Infections epidemiology, Infections genetics, Infections microbiology, Klebsiella drug effects, Klebsiella pathogenicity, Microbial Sensitivity Tests, Plasmids genetics, Replicon genetics, Tertiary Care Centers, Drug Resistance, Multiple, Bacterial genetics, Infections drug therapy, Klebsiella genetics, Phylogeny, beta-Lactamases genetics
- Abstract
Background & Objectives: β-lactamases play a predominant role in drug-resistance amongst Enterobacteriaceae. Presence of genes on transferable plasmids encoding these enzymes favours their dissemination across species and genera within and outside geographical boundaries. This study was aimed to understand the presence of β-lactamases and transferable plasmids in clinical isolates of Klebsiella spp. which can contribute to the spread of resistance determinants., Methods: A total of 41 clinical isolates of Klebsiella spp., collected from a tertiary care centre in Kerala, India, were checked for antibiotic sensitivity and the presence of plasmids. The ability to produce extended-spectrum β-lactamases (ESBLs) and metallo-β-lactamases (MBLs) was screened for and confirmed in 29 plasmid-harbouring isolates. blaNDM-1-specific primers were used for polymerase chain reaction amplification with plasmid DNA as template to determine episomal prevalence of this gene and its sequence-based phylogeny employing similar sequences from GenBank. Plasmid replicon typing was also carried out to determine the presence of transferable plasmids., Results: Our results showed a high degree of multidrug-resistant (MDR) pathogens with ESBL production confirmed in 52 per cent, MBL in 31 per cent and co-production of both enzymes in seven per cent of the plasmid-bearing isolates. Plasmid DNA from 14 per cent of the isolates produced blaNDM-1-specific amplicons which showed sequence homology with those from bacteria of different genera and geographical areas. The predominant replicon type was found to be that of conjugative plasmids belonging to the incompatibility group - IncFIIK., Interpretation & Conclusions: This study provides insight into the predominance of various β-lactamases and potent gene-disseminating agents in Klebsiella spp. and emphasizes the need for constant surveillance of these pathogens to determine appropriate treatment strategies.
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- 2017
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20. Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India.
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Rawat A, Vignesh P, Sharma A, Shandilya JK, Sharma M, Suri D, Gupta A, Gautam V, Ray P, Rudramurthy SM, Chakrabarti A, Imai K, Nonoyama S, Ohara O, Lau YL, and Singh S
- Subjects
- Age of Onset, Anti-Infective Agents therapeutic use, Antibiotic Prophylaxis, Child, Preschool, Coinfection, DNA Mutational Analysis, Female, Follow-Up Studies, Granulomatous Disease, Chronic diagnosis, Granulomatous Disease, Chronic etiology, Humans, Immunophenotyping, India epidemiology, Infant, Infection Control, Infections diagnosis, Infections drug therapy, Male, Mortality, Mutation, Phenotype, Tertiary Care Centers, Granulomatous Disease, Chronic complications, Granulomatous Disease, Chronic epidemiology, Infections epidemiology, Infections etiology
- Abstract
Purpose: Chronic granulomatous disease (CGD) is an inherited phagocytic disorder characterized by recurrent infections with usually catalase-positive organisms. Infections in CGD from developing countries are expected to be different from those in the Western countries. We report the profile of infections in children diagnosed with CGD from a tertiary care center in North India., Methodology: Case records of children diagnosed with CGD at Pediatric Immunodeficiency Clinic, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India, from August 1993 to April 2016 (23 years) were analyzed., Results: Thirty-eight children were diagnosed to have CGD. Median follow-up of patients was 2 years (interquartile range 0.75, 6.0). Staphylococcus aureus and Pseudomonas spp. were the two most common causative bacteria isolated. Aspergillus was the most common fungus isolated. The most common organ involved was the lung (94.7%). Liver abscesses were identified in 5 patients (13.2%), and 20 (52.6%) patients had lymphadenitis. Infections with Pseudomonas spp. were high in our cohort (15.7%) compared to the other studies. Infections with some unusual organisms (e.g., Fusarium dimerium and Chryseobacterium gleum) were also seen in our cohort. Children with X-linked CGD presented earlier and also had a greater number of infections as compared to autosomal recessive CGD., Conclusions: Various socioeconomic factors coupled with the lack of awareness and paucity of readily available diagnostic facilities for primary immunodeficiencies accounted for a late clinical presentation with severe infections and increased mortality (28.9%) in our cohort. However, mortality was similar in X-linked and autosomal recessive CGD as was the number of fungal infections. The incidence of infections and mortality was significantly lower after initiation of antibacterial and antifungal prophylaxis.
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- 2017
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21. Comparison of outcomes at 6 weeks following postpartum intrauterine contraceptive device insertions by doctors and nurses in India: a case-control study.
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Yadav V, Balasubramaniam S, Das S, Srivastava A, Srivastava A, Kumar S, and Sood B
- Subjects
- Adult, Case-Control Studies, Family Planning Services, Female, Humans, India, Infections epidemiology, Intrauterine Device Expulsion, Logistic Models, Midwifery, Nurses, Physicians, Treatment Outcome, United States, United States Public Health Service, Intrauterine Devices adverse effects, Postpartum Period
- Abstract
Objective: As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--for physicians and nurses/midwives to generate evidence for task sharing., Study Design: We analyzed secondary data from the PPIUCD program in seven states using a case-control study design. We included facilities where both doctors and nurses/midwives performed PPIUCD insertions and where five or more cases of expulsion and/or infection were reported during the study period (January-December 2013). For each case of expulsion and infection, we identified a time-matched control who received a PPIUCD at the same facility and had no complaints. We performed a multiple logistic regression analysis focusing on provider cadre while controlling for potential confounding factors., Results: In 137 facilities, 792 expulsion and 382 infection cases were matched with 1041 controls. Provider type was not significantly associated with either expulsion [odds ratio (OR) 1.84; 95% confidence interval (CI): 0.82-4.12] or infection (OR 0.73; 95% CI: 0.39-1.37). Compared with centralized training, odds of expulsion were higher for onsite (OR 2.32, 95% CI: 1.86-2.89) and on-the-job training (OR 1.23, 95% CI: 1.11-1.36), but odds of infection were lower for onsite (OR 0.45, 95% CI: 0.27-0.75) and on-the-job training (OR 0.31, 95% CI: 0.25-0.37)., Conclusion: Trained nurses and midwives who conduct deliveries at public health facilities can perform PPIUCD insertions as safely as physicians., Implications: Institutional deliveries are increasing in India, but most normal vaginal deliveries at public health facilities are attended by nurses and midwives due to a shortage of physicians. Task sharing with nurses and midwives can increase women's access to and the acceptability of quality PPIUCD services., (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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22. Interventions to increase immunisation coverage among children 12-23 months of age in India through participatory learning and community engagement: pilot study for a cluster randomised trial.
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Johri M, Chandra D, Koné GK, Dudeja S, Sylvestre MP, Sharma JK, and Pahwa S
- Subjects
- Cluster Analysis, Feasibility Studies, Female, Follow-Up Studies, Humans, India epidemiology, Infant, Infant, Newborn, Morbidity trends, Pilot Projects, Retrospective Studies, Immunization trends, Infection Control methods, Infections epidemiology, Rural Population
- Abstract
Objective: With the aim of conducting a future cluster randomised trial to assess intervention impact on child vaccination coverage, we designed a pilot study to assess feasibility and aid in refining methods for the larger study., Trial Design: Cluster-randomised design with a 1:1 allocation ratio., Methods: Clusters were 12 villages in rural Uttar Pradesh. All women residing in a selected village who were mothers of a child 0-23 months of age were eligible; participants were chosen at random. Over 4 months, intervention group (IG) villages received: (1) home visits by volunteers; (2) community mobilisation events to promote immunisation. Control group (CG) villages received community mobilisation to promote nutrition. A toll-free number for immunisation was offered to all IG and CG village residents. Primary outcomes were ex-ante criteria for feasibility of the main study related to processes for recruitment and randomisation (50% of villages would agree to participate and accept randomisation; 30 women could be recruited in 70% of villages), and retention of participants (50% of women retained from baseline to endline). Clusters were assigned to IG or CG using a computer-generated randomisation schedule. Neither participants nor those delivering interventions were blinded, but those assessing outcomes were blinded to group assignment., Results: All villages contacted agreed to participate and accepted randomisation. 36 women were recruited per village; 432 participants were randomised (IG n=216; CG n=216). No clusters were lost to follow-up. The main analysis included 86% (373/432) of participants, 90% (195/216) from the IG and 82% (178/216) from the CG., Conclusions: Criteria related to feasibility were satisfied, giving us confidence that we can successfully conduct a larger cluster randomised trial. Methodological lessons will inform design of the main study., Trial Registration Number: ISRCTN16703097., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
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- 2015
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23. Epidemiological and clinical profile of hospitalized children with moderate and severe acute malnutrition in South India.
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Devi RU, Krishnamurthy S, Bhat BV, and Sahai A
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- Anthropometry methods, Body Height, Body Weight, Breast Feeding statistics & numerical data, Case-Control Studies, Child, Preschool, Comorbidity, Female, Humans, India epidemiology, Infant, Male, Prospective Studies, ROC Curve, Risk Factors, Rural Population statistics & numerical data, Severity of Illness Index, Anemia epidemiology, Infections epidemiology, Severe Acute Malnutrition diagnosis, Severe Acute Malnutrition epidemiology, Severe Acute Malnutrition physiopathology
- Abstract
Objective: To evaluate the clinico-epidemiological profile, pattern of infections, feeding practices, socio-demographic risk factors and outcome of hospitalized children with moderate acute malnutrition (MAM) and severe acute malnutrition (SAM)., Methods: Cases (children aged 1-60 mo with SAM or MAM) and controls (children with weight for height z score more than -1 SD) were recruited from November 2011 through July 2013. Overall, 126 cases and 126 controls were included., Results: Only 33 % of malnourished children (cases) were exclusively breast fed. Among controls, 71 % were exclusively breast fed for the first 6 mo after birth. Most cases had associated infections (p 0.004) and anemia (p < 0.001). ROC curve revealed 120 mm mid upper arm circumference (MUAC) as the best cut off for predicting SAM. Mothers' education, pre-lacteal feeds and co-morbidities were independent predictors of malnutrition (R(2) = 22.1 %) by logistic regression., Conclusions: Though 11.5 cm MUAC has been mentioned by WHO as the cut off for identifying SAM, a higher cut off (12 cm) may be required to use it as a screening tool. Mothers' education, pre-lacteal feeds and co-morbidities were found to be independent determinants for malnutrition in the present patient population, indicating the need towards a targeted approach for modifying these factors.
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- 2015
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24. Pattern of pediatric dermatoses in Kashmir valley: a study from a tertiary care center.
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Hassan I, Ahmad K, and Yaseen A
- Subjects
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, India epidemiology, Infant, Infant, Newborn, Infections epidemiology, Male, Ethnicity, Skin Diseases epidemiology
- Published
- 2014
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25. Decreasing prevalence of transfusion transmitted infection in Indian scenario.
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Chandra T, Rizvi SN, and Agarwal D
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- Blood Donors, Blood-Borne Pathogens, Humans, India epidemiology, Infections etiology, Infections microbiology, Infections epidemiology, Transfusion Reaction
- Abstract
Transfusion transmitted infections are major problem associated with blood transfusion. Accurate estimates of risk of TTIs are essential for monitoring the safety of blood supply and evaluating the efficacy of currently employed screening procedures. The present study was carried out to assess the percentage of voluntary donors and replacement donors and to find out prevalence and changing trends of various TTIs blood donors in recent years. A study was carried out on blood units of voluntary and replacement donors which were collected from January 2008 to December 2012. On screening of 180,371 replacement units, seropositivity of transfusion transmitted disease in replacement donors was 0.15% in HIV, 1.67% in hepatitis B surface antigen, 0.49% in hepatitis C virus, 0.01% in VDRL, and 0.009% in malaria. Of 11,977 voluntary units, seropositivity of transfusion transmitted disease in voluntary donors was 0.08% in HIV, 0.24% in hepatitis B surface antigen, 0.001% in hepatitis C virus, 0.008% in VDRL (sexually transmitted disease), and 0.01% in malaria. From results it has been concluded that prevalence of transfusion transmitted infection (HIV, HBV, HCV, VDRL, and malaria) was more in replacement donors in comparison to voluntary donors. Extensive donor selection and screening procedures will help in improving the blood safety.
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- 2014
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26. Semiparametric additive marginal regression models for multiple type recurrent events.
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Chen X, Wang Q, Cai J, and Shankar V
- Subjects
- Computer Simulation, Humans, India epidemiology, Infections epidemiology, Infections etiology, Kidney Transplantation adverse effects, Kidney Transplantation statistics & numerical data, Recurrence, Regression Analysis, Biomedical Research methods, Data Interpretation, Statistical, Models, Statistical
- Abstract
Recurrent event data are often encountered in biomedical research, for example, recurrent infections or recurrent hospitalizations for patients after renal transplant. In many studies, there are more than one type of events of interest. Cai and Schaube (Lifetime Data Anal 10:121-138, 2004) advocated a proportional marginal rate model for multiple type recurrent event data. In this paper, we propose a general additive marginal rate regression model. Estimating equations approach is used to obtain the estimators of regression coefficients and baseline rate function. We prove the consistency and asymptotic normality of the proposed estimators. The finite sample properties of our estimators are demonstrated by simulations. The proposed methods are applied to the India renal transplant study to examine risk factors for bacterial, fungal and viral infections.
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- 2012
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27. Pattern and causes of amputation in diabetic patients--a multicentric study from India.
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Viswanathan V and Kumpatla S
- Subjects
- Adult, Age Distribution, Aged, Aged, 80 and over, Diabetic Foot epidemiology, Female, Humans, India epidemiology, Infections complications, Infections epidemiology, Leg Injuries complications, Leg Injuries epidemiology, Male, Middle Aged, Prevalence, Risk Factors, Sex Distribution, Toes surgery, Young Adult, Amputation, Surgical statistics & numerical data, Diabetes Mellitus, Type 2 complications, Diabetic Foot etiology, Diabetic Foot surgery
- Abstract
Objective: One of the most significant complications of diabetes is foot disease, which often leads to amputations was found to be very common in developing countries like India, the diabetic capital of the world. Hence this study has been planned to assess the pattern and causes of amputations in diabetic patients across various parts of India., Subjects and Methods: A total of 1985 (M:F 1249:736) type 2 diabetic subjects were selected from 31 centres across India. Out of 1985 subjects, a total of 1295 (850:445) patients who had undergone amputations both major and minor were included in this analysis. A proforma which contains details on level of amputations, diabetes history, deformity details, causes of amputations and other associated diabetic complications was used to collect the data. Peripheral vascular disease was assessed by using Doppler studies. Presence of neuropathy was assessed by using 10 g monofilament and 125 Hz tuning fork., Results: The major cause for the occurrence of amputations among the patients was found to be infection. Almost 90% of the patients had infection. Patients had different types of amputations: major amputations accounting for 29.1% (n=377) and minor amputations in 70.9% (n=918) of subjects. Among the subjects who underwent major amputations, more than 50% accounts for below knee amputations and 11.9% above knee amputations. Out of total amputations, over half of the incident amputations were of toes and rays. Presence of claw toes was seen in 64% of patients. Prevalence of neuropathy (82%) was high and 35% had peripheral vascular disease., Conclusion: In conclusion, infection was found to be the major cause of amputation in India. Below knee, toes and rays amputations were the most common type of amputations. Diabetic patients should be educated on foot care and importance of proper foot wear.
- Published
- 2011
28. Early infections in the stem cell transplant recipients at AIIMS, New Delhi: a prospective study.
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Bhat GM, Kumar L, Sharma A, and Kuchupillai V
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- Adolescent, Adult, Aged, Child, Female, Humans, India, Male, Middle Aged, Prospective Studies, Hematopoietic Stem Cell Transplantation adverse effects, Infections epidemiology
- Abstract
Unlabelled: The pattern of infections in neutropenic patients including those undergoing stem cell transplant in the west has changed but the same may not be the case in the developing countries as brought out through some earlier observations in some transplant centers in India. The department of medical oncology IRCH, AIIMS has been providing bone marrow transplant facility for over a decade now. It is one of the few bone marrow transplant units in northern India. A prospective study conducted on 70 consecutive bone marrow transplant subjects at this center was carried out with this perspective in view., Objectives: To determine the frequency and pattern of infections in haemopoietic stem cell transplant (HSCT) recipients at this center in India.
- Published
- 2010
29. Patterns of infections among blood donors in a tertiary care centre: a retrospective study.
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Kaur G, Basu S, Kaur R, Kaur P, and Garg S
- Subjects
- Blood-Borne Pathogens, Humans, India epidemiology, Prevalence, Retrospective Studies, Blood Donors, Infections epidemiology
- Abstract
Background: Transfusion-transmitted infections continue to be a threat to safe transfusion practices. We analysed the prevalence and patterns of co-infections among voluntary and replacement donors., Methods: Blood donations collected over a 5-year period were studied for the type of donation (voluntary or replacement), number of seroreactive cases and the number, type and distribution of co-infections., Results: Of the 42 439 units of blood collected over a 5-year period, 19 118 (45%) were from voluntary and 23 321 (55%) from replacement donors. There were 1603 seroreactive cases (3.8%). These included 250 with HIV (0.6%), 734 with hepatitis B surface antigen (HBsAg; 1.7%), 337 with hepatitis C virus (HCV; 0.8%) and 282 (0.7%) with VDRL (Venereal Diseases Research Laboratory) reactivity. Twenty-three (0.05%) of these had > or = 2 seroreactive infections; 20 of these were in replacement donors and only 3 in voluntary donors and the difference was statistically significant (p < 0.005). Among HIV seropositive donors, there were 4 seroreactive for syphilis and 5 for HBsAg. Among HIV seronegative donors, 5 were seroreactive for HBsAg and VDRL, 4 for HCV and VDRL, and 2 for HBsAg and HCV. One person was seroreactive for HIV, HBsAg and VDRL. The multiple infection rate showed a decreasing trend over the years., Conclusion: Multiple infections pose a small but definite risk to the recipients of blood products. Voluntary donations are safer as compared with replacement ones and need to be encouraged.
- Published
- 2010
30. Morbidity among infants in South India: a longitudinal study.
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Joseph N, Subba SH, Naik VA, Mahantshetti NS, and Mallapur MD
- Subjects
- Diarrhea, Infantile epidemiology, Female, Humans, India epidemiology, Infant, Infant, Newborn, Infections epidemiology, Male, Respiratory Tract Infections, Morbidity
- Abstract
To study the incidence and types of morbidity in the first year of life in a birth cohort, a longitudinal study. This study was undertaken in northern part of Karnataka state in India. Birth cohort consisted of all the children born during first six months of the study period. They were assessed at the time of enrollment and monthly follow up was done till they attained one yr of age. Out of the 194 newborns, 46.4% were boys and 53.6% were girls. 24.8% of newborns were of low birth weight and 5.1% were preterm. Four (2.1%) had congenital anomalies and 2.5% developed birth asphyxia. Diarrhea (10.8%) and skin diseases (8.2%) were the commonest morbidities in the neonatal period. The incidence of morbidity was 3.28 per infant per yr. It was more among boys and in the second half of infancy. Commonest morbidities during infancy were respiratory tract infection (62.4%), diarrhea 42.8% and skin diseases (21.6%). Incidence of disease in infancy highlights the need to improve and plan health programmes.
- Published
- 2010
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31. Undernutrition & risk of infections in preschool children.
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Ramachandran P and Gopalan HS
- Subjects
- Body Mass Index, Child Nutrition Disorders pathology, Child, Preschool, Comorbidity, Female, Health Surveys, Humans, India epidemiology, Infant, Infant Nutrition Disorders epidemiology, Infant Nutrition Disorders pathology, Infant, Newborn, Male, Nutritional Status, Risk Factors, Thinness epidemiology, Child Nutrition Disorders epidemiology, Infections epidemiology
- Abstract
Background & Objective: It is well documented that in preschool children undernutrition is associated with immune depression and increased risk of infections; infections aggravate undernutrition. Underweight is the most widely used indicator for assessment of undernutrition for investigating undernutrition and infection interactions. In India, nearly half the children are stunted and underweight; but majority of children have appropriate weight for their height and less than a fifth are wasted. The present study was undertaken to explore which of the five anthropometric indices for assessment of undernutrition (weight for age, height for age, wasting, BMI for age, and wasting and stunting with low BMI) is associated with more consistent and higher risk of morbidity due to infection in preschool children., Methods: The National Family Health Survey-3 (NFHS-3) database provided the following information in 56,438 preschool children: age, sex, weight, height, infant and young child feeding practices and morbidity due to infections in the last fortnight. Relative risk (RR) of morbidity due to infections was computed in infants and children with stunting, underweight, low BMI for age, wasting and stunting with low BMI (< mean-2SD of WHO 2006 standards)., Results: Comparison of the RR for infections in undernourished children showed that the relative risk of morbidity due to infections was higher and more consistently seen in children with low BMI and wasting as compared to stunting or underweight. The small group of children who had stunting with wasting had the highest relative risk of morbidity due to infection., Interpretation & Conclusion: In Indian preschool children, RR for infection was more consistently associated with BMI for age and wasting as compared to weight for age and height for age. Low BMI for age and wasting indicate current energy deficit; early detection and correction of the current energy deficit might reduce the risk of infection and also enable the child to continue in his/her growth trajectory for weight and height.
- Published
- 2009
32. Outcome of lupus nephritis in Indian children.
- Author
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Hari P, Bagga A, Mahajan P, and Dinda A
- Subjects
- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Glomerular Filtration Rate, Hematuria epidemiology, Hematuria etiology, Humans, Hypertension epidemiology, Hypertension etiology, India epidemiology, Infections epidemiology, Infections mortality, Kidney Failure, Chronic epidemiology, Kidney Failure, Chronic mortality, Lupus Nephritis classification, Lupus Nephritis complications, Lupus Nephritis mortality, Male, Nephrotic Syndrome epidemiology, Nephrotic Syndrome etiology, Proportional Hazards Models, Proteinuria epidemiology, Proteinuria etiology, Remission Induction methods, Retrospective Studies, Sex Factors, Survival Rate, Treatment Outcome, Infections etiology, Kidney Failure, Chronic etiology, Lupus Nephritis physiopathology
- Abstract
We report the clinicopathological features, treatment and outcome of 54 Indian children (14 boys) with biopsy-proven lupus nephritis followed over a 10-year period. The mean age (SD) at onset of disease was 9.6 +/- 2.6 (range 2.5-14.4) years. Twenty-six (48.1%) patients had class IV nephritis, 7 (13.0%) had class V, whereas class I, II and III nephritis were present in 3 (5.6%), 10 (18.5%) and 6 (11.1%) patients, respectively. Hypertension, haematuria and nephrotic range proteinuria were present in 30 (55.6%), 31 (57.4%) and 28 (51.8%) patients, respectively. Compared with all the other classes combined, there were more boys among patients with class IV nephritis, and hypertension, haematuria, nephrotic syndrome and decreased glomerular filtration rate at presentation were more common. The mean duration of follow-up was 3.1 +/- 2.9 years (median 2.5, range 0.2-10.3 years). Of the 39 patients who were followed-up for at least 1 year, 33 (84.6%) were in complete or partial remission, whereas six (15.4%) had no response to therapy. The incidence of serious infection was 1.5 episodes per 10 patient-years. Nine patients died, of whom four had serious infections or septicaemia, and three developed end-stage renal failure (ESRF). The patient survival rate at 3 years and at last follow-up visit was 88% and 83.3%, respectively, whereas the renal survival rates (without ESRF) were 92% and 94.4% respectively. Cox regression analysis showed no relation of gender, age of onset, presence of hypertension, haematuria and proteinuria, estimated glomerular filtration rate, renal histology and response to therapy to the outcome of death or ESRF. We found lower patient survival rate as compared with data from the developed countries but similar to that seen in developing countries. Serious infections were an important cause of mortality besides renal failure.
- Published
- 2009
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33. Clinicopathologic profile of normocomplementemic and hypocomplementemic urticarial vasculitis: a study from South India.
- Author
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Dincy CV, George R, Jacob M, Mathai E, Pulimood S, and Eapen EP
- Subjects
- Adolescent, Adult, Arthritis, Juvenile epidemiology, Biopsy, Complement C1q deficiency, Complement C1q metabolism, Complement C3 deficiency, Complement C3 metabolism, Complement C4 deficiency, Complement C4 metabolism, Dermis blood supply, Dermis pathology, Epidermis pathology, Female, Fluorescent Antibody Technique, Direct, Humans, India epidemiology, Infections epidemiology, Male, Middle Aged, Mixed Connective Tissue Disease epidemiology, Neoplasms epidemiology, Prevalence, Prospective Studies, Urticaria blood, Urticaria pathology, Vasculitis blood, Complement System Proteins deficiency, Complement System Proteins metabolism, Lupus Erythematosus, Systemic epidemiology, Urticaria epidemiology, Vasculitis epidemiology
- Abstract
Background: This study aims to study the clinical and histopathological characteristics of hypocomplementemic and normocomplementemic urticarial vasculitis (HUVS and NUV) among dermatology clinic attendees in a tertiary care hospital in South India., Patients and Methods: A prospective study was conducted in the dermatology department from February 2003 to May 2004. Seventy-five patients met the inclusion criteria for UV. Sixty-eight patients in whom complement levels were available were classified into either NUV or HUVS groups. Clinical features, laboratory parameters and histological features were compared, and the significance of differences was established using Pearson's Chi-squared test., Results: There was a female preponderance among patients with HUVS. Wheals > 24 h were seen in 90% of patients, and in 54.4% of patients, the wheals were partially blanching or non-blanching. Angioedema was more prevalent in patients with NUV than HUVS (44.4% vs. 21.4%). Systemic involvement was seen in 64.3% of patients with HUVS and 44.4% of patients with NUV. Fever, ANA positivity and systemic lupus erythematosus (SLE) were significantly associated with HUVS. In most cases of UV, a provoking factor could not be identified. Neutrophilic small vessel vasculitis was seen in 42.9% of patients with HUVS and 16.6% patients with NUV. Direct immunofluorescence test showing immunoreactants at the dermo-epidermal junction were present in 60% of patients with HUVS and 33.3% patients with NUV., Conclusion: The clinical features of Indian patients with UV were similar to those reported from the West. Fever, ANA positivity and SLE were significantly associated with HUVS.
- Published
- 2008
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34. Ethics in nutrition intervention research.
- Author
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Ramanthan M and Jesani A
- Subjects
- Child, Child Nutrition Disorders epidemiology, Child Nutrition Disorders prevention & control, Dietary Supplements, Humans, India epidemiology, Infection Control, Infections epidemiology, Child Advocacy ethics, Child Nutrition Disorders etiology, Controlled Clinical Trials as Topic ethics, Infections complications, Multicenter Studies as Topic ethics
- Published
- 2007
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35. Syndromic approach for determination of reproductive tract infections among adolescent girls.
- Author
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Ram R, Bhattacharyya K, Goswami DN, Baur B, Dasgupta U, and Sarkar AP
- Subjects
- Adolescent, Age Factors, Demography, Educational Status, Female, Humans, India epidemiology, Infections diagnosis, Prevalence, Risk Assessment, Socioeconomic Factors, Syndrome, Infections epidemiology
- Abstract
The present study shows overall prevalence (64%) of reproductive tract infection among adolescent girls, based on self-perceived symptoms. Mean age of respondents were found to be 17.8 +/- 0.82 years and mean age at marriage and mean age at first pregnancy were 17.2 years and 17.5 years respectively; 35.35% of girls in the present study were married. In addition, no significant difference was observed between unmarried (60.10%) and married (71.17%) reproductive tract infection groups. Moreover, no significant association was present in prevalence of reproductive tract infection between the Muslim (67%) and the Hindu (60%). Highest prevalence (84.06%) of reproductive tract infection was observed among illiterate girls and with improvement of educational status there was decrease in the prevalence and the association was found highly significant. Significantly, higher prevalence (72%) was observed among members of family size 7 and above.
- Published
- 2006
36. Profile of diabetic foot complications and its associated complications--a multicentric study from India.
- Author
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Viswanathan V, Thomas N, Tandon N, Asirvatham A, Rajasekar S, Ramachandran A, Senthilvasan K, Murugan VS, and Muthulakshmi
- Subjects
- Adult, Age Factors, Diabetic Foot complications, Diabetic Foot epidemiology, Diabetic Foot surgery, Female, Humans, India epidemiology, Infections epidemiology, Infections etiology, Male, Middle Aged, Peripheral Vascular Diseases epidemiology, Prevalence, Risk Factors, Surveys and Questionnaires, Amputation, Surgical statistics & numerical data, Diabetes Mellitus, Type 2 complications, Diabetic Foot prevention & control, Peripheral Vascular Diseases etiology, Self Care
- Abstract
Aim: The aims of this study were to determine. The prevalence of foot complications such as neuropathy, peripheral vascular disease (PVD), amputations and infections and the associated diabetic complications and practice of foot care among these subjects., Methods: A total of 1319 type 2 diabetic patients, were selected from four different centres across India. The centres were Diabetes Research Centre (DRC), Chennai, Government Rajaji Hospital (GRH), Madurai, Christian Medical College (CMC), Vellore and All India Institute of Medical Science (AIIMS), Delhi. Details were collected regarding foot problems and associated complications., Results: The prevalence of neuropathy was 15% (n=193) and PVD was 5% (n=64). Infections were present in 7.6% (n=100) of patients. The infection rate varied from 6-11% in the different centres. Nearly 3% of subjects had undergone a minor or major amputation., Discussion: This study found that the prevalence of infection was 6-11% and prevalence of amputation was 3% in type 2 diabetic patients. Neuropathy (15%) was found to be an important risk factor for diabetic foot infections. Effective foot care advice should be propagated to reduce the burden imposed by diabetic foot complication particularly in developing countries like India.
- Published
- 2005
37. Reproductive tract infections among young married women in Tamil Nadu, India.
- Author
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Prasad JH, Abraham S, Kurz KM, George V, Lalitha MK, John R, Jayapaul MN, Shetty N, and Joseph A
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Evaluation Studies as Topic, Female, Humans, India epidemiology, Infections classification, Infections diagnosis, Infections etiology, Likelihood Functions, Patient Acceptance of Health Care, Prevalence, Infections epidemiology, Spouses
- Abstract
Context: Women often suffer silently with reproductive tract infections (RTIs). Studies of the prevalence of these infections in South Asia have been hindered by low participation rates, and little is known about rates among the youngest married women., Methods: A community-based cross-sectional study of RTIs was conducted in 1996-1997 among married women 16-22 years of age in Tamil Nadu, India. The women were questioned about symptoms, received pelvic and speculum examinations and provided samples for laboratory tests. Qualitative and quantitative data on treatment-seeking behavior were collected., Results: Fifty-three percent of women reported gynecologic symptoms, 38% had laboratory findings of RTIs and 14% had clinically diagnosed pelvic inflammatory disease or cervicitis. According to laboratory diagnoses, 15% had sexually transmitted infections and 28% had endogenous infections. Multivariate analysis found that women who worked as agricultural laborers had an elevated likelihood of having a sexually transmitted infection (odds ratio, 2.4), as did those married five or more years (2.1). Two-thirds of symptomatic women had not sought any treatment; the reasons cited were absence of a female provider in the nearby health care center, lack of privacy, distance from home, cost and a perception that their symptoms were normal., Conclusions: Young married women in this rural Indian community have a high prevalence of RTIs but seldom seek treatment. Education and outreach are needed to reduce the stigma, embarrassment and lack of knowledge related to RTIs. The low social status of women, especially young women, appears to be a significant influence on their low rates of treatment for these conditions.
- Published
- 2005
- Full Text
- View/download PDF
38. Prevalence of reproductive tract infections in rural Goa.
- Author
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Vaz FS and Ferreira AM
- Subjects
- Abdominal Pain epidemiology, Abdominal Pain etiology, Female, Humans, India epidemiology, Infections complications, Infections diagnosis, Male, Prevalence, Risk Factors, Rural Population, Sex Factors, Vaginal Discharge epidemiology, Vaginal Discharge etiology, Infections epidemiology, Public Health
- Published
- 2005
39. Reproductive tract infection: an experience in rural West Bengal.
- Author
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Dawn A and Biswas R
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Educational Status, Female, Humans, Income, India epidemiology, National Health Programs statistics & numerical data, Women's Health, Health Knowledge, Attitudes, Practice, Health Services statistics & numerical data, Infections epidemiology, Rural Population statistics & numerical data
- Abstract
A community based cross-sectional study was conducted in the villages of Singur block, Hooghly district, West Bengal during September 2000 to February 2001. The objectives of the study were to find out the magnitude of Reproductive Tract Infections (RTI) among reproductive age group women, their knowledge about RTI and utilization of service available locally. Out of an estimated 896 women of reproductive age group in the study area, 186 women were selected by multistage random sampling technique. The study revealed that 66.1% respondents experienced one or more symptoms of RTI in four weeks recall period of this study. There was significant association (p < 0.01) between literacy status and their experiences of reproductive illness. 57% had knowledge about RTI. This increased gradually with increase of their ages (p < 0.01); literacy status (p < 0.01) and their socio-economic condition (p < 0.05). 27.6% of RTI patient did not receive any treatment, and majority of those received treatment (41.5%) sought advice from private practitioners.
- Published
- 2005
40. Infectious markers in blood donors of East Delhi: prevalence and trends.
- Author
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Singh B, Kataria SP, and Gupta R
- Subjects
- Cardiolipins blood, Cholesterol blood, HIV Infections blood, HIV Infections transmission, HIV Seropositivity, Hepatitis B blood, Hepatitis B transmission, Hepatitis B Surface Antigens blood, Hepatitis C blood, Hepatitis C transmission, Humans, India epidemiology, Infections transmission, Phosphatidylcholines blood, Syphilis blood, Syphilis transmission, Transfusion Reaction, Blood Donors, Infections blood, Infections epidemiology
- Abstract
All blood donors Voluntary and Replacement who have donated blood in the centre or in the voluntary blood donation camps, were analyzed for the prevalence of infectious markers over a period of 3 years from 1997 to 1999. A total of 52500 blood units were collected and screened for hepatitis B surface antigen (HBsAg), antibodies to HIV I and II and VDRL reactivity. Seropositivity was 471 (0.8%) for HIV I and II, 963 (1.8%) for HbsAg, 1449 (2.76%) for VDRL and 64 (0.5%) for anti HCV. Voluntary donors were comparatively safe. The seropositivity for HIV showed increasing trend between 1997 to 1999.
- Published
- 2004
41. Sickle cell disease in central India.
- Author
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Patel AB and Athavale AM
- Subjects
- Child, Female, Humans, Incidence, India epidemiology, Infections epidemiology, Male, Prospective Studies, Protein-Energy Malnutrition epidemiology, Risk Factors, Social Class, Treatment Refusal, Anemia, Sickle Cell epidemiology
- Abstract
Objective: The incidence and the risk factors of sickle cell disease (SCD), vaccinated with Pneumococcal vaccine and on penicillin prophylaxis has not been previously reported in India., Methods: This prospective hospital based study followed 325 children on penicillin prophylaxis, of which 161 were vaccinated for pneumococci, over 146.84 person years to determine the incidence and determinants of crisis (SCC) and infections. The average age at presentation was 7.05 +/- 3.26 years with male preponderance below 2 years., Results: The main causes for hospitalizations were for blood transfusion, SCC and infections. The incidence of SCC was 1.25 per patient per year and that of infection was 1.38 per person per year. The risk factors for SCC were Mahar caste (p = 0.007) non-compliance (p = 0.000) and protein energy malnutrition (PEM) (p = 0.0015) and for infection were also PEM (p = 0.023), Mahar caste (p = 0.021) and noncompliance (p = 0.001)., Conclusion: Malnutrition and non-compliance with medication increased the patient's susceptibility to SCC and infections.
- Published
- 2004
- Full Text
- View/download PDF
42. Observations on the proposed relationship between infection burden and early malignancy in developing countries (e.g., India).
- Author
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Vijh AK
- Subjects
- Age Distribution, Aging, Causality, Comorbidity, Humans, Incidence, India epidemiology, Infections genetics, Neoplasms genetics, Precancerous Conditions genetics, Prevalence, Risk Factors, Telomere genetics, Telomere ultrastructure, Developing Countries statistics & numerical data, Disease Susceptibility epidemiology, Infections epidemiology, Neoplasms epidemiology, Precancerous Conditions epidemiology, Risk Assessment methods
- Abstract
Sastry and Parikh [Med. Hypotheses 60(4) (2003) 573] have recently sought an explanation for the fact that the occurrence of a particular cancer in populations in a developing country such as India takes place at a younger age (about one decade) than in populations in Western countries. They have hypothesized that a higher infectious burden in India gives rise to repeated cell divisions leading to early senescence of immune cells, and, thence their reduced ability for immune surveillance against cancer, resulting in earlier onset of cancer. The analysis presented here points out to some difficulties with this interpretation, both on empirical and theoretical grounds. The reduced surveillance ability, caused by higher infectious burden, of the immune cells postulated by Sastry and Parikh [loc. cit.] would also mean that populations in India should suffer higher incidence of cancer, as compared to people in Western countries; the empirical data show that, in fact, quite the opposite is true - in the present communication shows that for many common cancers, typical cities in India show the lowest incidence. Theoretically, it is postulated here that repeated heavy infections in India, in fact, challenge the immune system, particularly the adaptive immune system and create an immunological memory: this trains and strengthens the immune system against the future battles. Also it is shown that the shortening of the telomeric cap by repeated cell divisions caused by heavy infectious attacks, as argued by Sastry and Parikh [loc. cit.], is not the cause of earlier onset of cancers among Indians; in fact, when telomeric caps become shortened to a critical point, a danger signal is generated arresting the cell cycle - thus, it provides a fundamental mechanism for ordering the cell to cease proliferation. It is suggested that the root of occurrence of cancers at an earlier age in India perhaps lies in the accumulation of mutations at an earlier age among Indians who do develop cancers; the factors responsible for these accelerated mutations are not clear at the present time and need further investigation.
- Published
- 2004
- Full Text
- View/download PDF
43. India's burden of waterborne diseases is underestimated.
- Author
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Mudur G
- Subjects
- Incidence, India epidemiology, Water Microbiology, Infections epidemiology, Water Supply standards
- Published
- 2003
- Full Text
- View/download PDF
44. Reproductive morbidity in an Indian urban slum: need for health action.
- Author
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Garg S, Sharma N, Bhalla P, Sahay R, Saha R, Raina U, Das BC, Sharma S, and Murthy NS
- Subjects
- Female, Humans, India epidemiology, Poverty Areas, Prevalence, Reproductive Medicine, Sexually Transmitted Diseases epidemiology, Urban Health, Genital Diseases, Female epidemiology, Infections epidemiology
- Published
- 2002
- Full Text
- View/download PDF
45. Reproductive tract infections in pregnant women in Delhi, India.
- Author
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Mayank S, Bahl R, and Bhandari N
- Subjects
- Cervix Uteri microbiology, Female, Gestational Age, Gravidity, Humans, India epidemiology, Infections blood, Pregnancy, Pregnancy Complications, Infectious blood, Socioeconomic Factors, Vagina microbiology, Vaginal Smears, Infections epidemiology, Pregnancy Complications, Infectious epidemiology
- Published
- 2001
- Full Text
- View/download PDF
46. Effectiveness of syndromic approach in management of reproductive tract infections in women.
- Author
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Singh MM, Devi R, Garg S, and Mehra M
- Subjects
- Adolescent, Adult, Female, Genital Diseases, Female diagnosis, Genital Diseases, Female epidemiology, Humans, Hygiene, India epidemiology, Infections diagnosis, Infections epidemiology, Treatment Outcome, Genital Diseases, Female therapy, Infections therapy
- Abstract
Syndromic approach was used to identify reproductive tract infections (RTI) by a trained public health nurse among 130 ever-married women aged 15-45 years selected by a systematic random sampling method in a resettlement colony, Chandigarh. A lady medical officer in the dispensary examined and treated 48 (37%) referred symptomatic women as per syndromic approach guidelines. They were suffering from vaginitis (52.1%), cervicitis (20.8%), pelvic inflammatory disease (PID) (14.6%), urinary tract infections and PID (4.2%) and 4 did not have any clinical abnormality. Poor menstrual hygiene was observed among 72.7% women with RTI. Follow-up done after one month showed effectiveness in terms of symptomatic relied in 72.7% while 9.1% discontinued treatment and 4.5% did not comply with the medications. Training of nurses, health workers, dais, anganwadi workers regarding RTI identification and referral using syndromic approach and promotion of menstrual hygiene, genital hygiene and health care seeking behaviour would help in reducing the burden of RTI in the community.
- Published
- 2001
47. Long-term outcome of living-unrelated donor kidney transplantation.
- Author
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Prabhakar KS, Vathsala A, and Woo KT
- Subjects
- Adult, Azathioprine therapeutic use, Cohort Studies, Cyclosporine therapeutic use, Drug Therapy, Combination, Family, Female, Graft Survival, Humans, Immunosuppressive Agents therapeutic use, India, Infections epidemiology, Kidney Transplantation immunology, Kidney Transplantation mortality, Male, Methylprednisolone therapeutic use, Postoperative Complications classification, Postoperative Complications epidemiology, Prednisolone therapeutic use, Singapore, Survival Rate, Time Factors, Treatment Failure, Treatment Outcome, Kidney Transplantation physiology, Living Donors
- Published
- 2000
- Full Text
- View/download PDF
48. Reproductive tract infections, gynaecological morbidity and HIV seroprevalence among women in Mumbai, India.
- Author
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Brabin L, Gogate A, Gogate S, Karande A, Khanna R, Dollimore N, de Koning K, Nicholas S, and Hart CA
- Subjects
- Adult, Case-Control Studies, Cross-Sectional Studies, Female, HIV Infections microbiology, Humans, India epidemiology, Infections microbiology, Pregnancy, Prevalence, HIV Infections epidemiology, Infections epidemiology, Infertility microbiology, Pelvic Inflammatory Disease microbiology
- Abstract
Reported are the prevalence of reproductive tract infections and their contribution to pelvic inflammatory disease (PID), as well as the seroprevalence of human immunodeficiency virus (HIV), among women living in three inner city wards of Mumbai, India. Women aged < or = 35 years were recruited and screened as cases if they had been admitted to hospital for gynaecological investigation for suspected PID (n = 151) or infertility (n = 295); controls were healthy fertile women attending for laparoscopic tubal ligation (n = 2433). The women were mainly of low socioeconomic status. A total of 59.4% were migrants and 14.9% of these came to Mumbai to seek treatment. Cases reported a history of adverse pregnancy outcomes significantly more often than controls, and 30.5% of suspected PID cases had previously undergone laparoscopic tubal ligation. At examination 24.2% of cases and 8.4% of controls had a vaginal discharge. Pelvic infection was confirmed in 42.0% of suspected PID cases and 14.6% of infertile cases for whom diagnostic laparoscopy was performed. The prevalence of sexually transmitted diseases was low: Chlamydia trachomatis was found in 0.2%; and Neisseria gonorrhoeae was cultured from the cervix in only four cases. Neither of these infections was detected in laparoscopic aspirates. The prevalence of HIV1/2 infections in unlinked samples was 1.9%. Sexually transmitted diseases were not major factors leading to gynaecological morbidity. Heterosexual spread of HIV infection to this population of married women is still relatively low but needs to be carefully monitored. The gynaecological morbidity detected may be a consequence of widespread use of invasive methods of fertility regulation.
- Published
- 1998
49. Microbiological quality & incidence of organisms of public health importance in food & water in Ludhiana.
- Author
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Ram S, Khurana S, Khurana SB, Vadehra DV, Sharma S, and Chhina RS
- Subjects
- Humans, Incidence, India, Food Microbiology, Gastroenteritis microbiology, Infections epidemiology, Infections microbiology, Public Health, Water Microbiology
- Abstract
Bacteriological analysis of 713 samples of various types of foods and related articles and potable water samples from different places in Ludhiana, Punjab was carried out. The highest counts ranging from 2.5 x 10(6)-7.5 x 10(8) organisms/g were observed in raw vegetables and fruits, followed by 3 x 10(6)-9.8 x 10(7)/ml, 8.3 x 10(4)-8.9 x 10(7)/g and 1 x 10(3)-6.7 x 10(7)/g in fruit juice, milk and its products, and salty/non milk snacks respectively. Fresh chapati, dal, rice, cooked vegetables and karhi etc., showed no microbial contamination. However, samples of these articles from road side cafes gave counts up to 1 x 10(7) organism/g. The most probable number of coliforms and Escherichia coli/100 ml of water ranged from < 1 to > 1100. Although 1332 isolates of 16 types of organisms of public health significance were obtained those of proven enteropathogenicity were enterotoxigenic Esch. coli (55), Esch. coli O157 (3), enteropathogenic Esch. coli (1), enterotoxigenic Klebsiella (23), Streptococcus faecalis (152), Bacillus cereus (133), Staphylococcus aureus (125), Aeromonas spp (47), Salmonella spp (10), Shigella spp (4) and Yersinia enterocolitica (2). Poor quality of potable water and widespread occurrence of enteropathogens in food consumed by the common man in Ludhiana was evident.
- Published
- 1996
50. Emerging and reemerging microbial threats.
- Author
-
Satyanarayana K and Medappa N
- Subjects
- Bacterial Infections epidemiology, Communicable Diseases epidemiology, Disease Outbreaks, Humans, India epidemiology, Protozoan Infections epidemiology, Infections epidemiology
- Published
- 1996
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