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The present study is aimed at evaluating the genotype frequency of detoxifying genes such as GSTM1, GSTT1 and NQO1 in Maharastrian population of central India. The study revealed about 64.6% of GSTM1-positive and 35.4% GSTM1-null population. GSTT1-positive genotype was found to be 87.5% and GSTT1-null showed 12.5%. The NQO1 genotype of Maharastrian population showed 52.3% of C/C, 42.48% C/T and 5.18% T/T. The NQO1 of this population does not deviate from the expected Hardy−Weinberg equilibrium. The genotype frequencies GSTM1 and GSTT1 of the population when compared with other ethnic groups of Asia and Caucasians show distinct nature of Maharastrian population from other Asian and Caucasian population. [Copyright &y& Elsevier]

The article presents a study on the induction of oxidative stress in relation to heavy metal exposure in diesel tuning workers in India. Subjects were chosen from the same area with one group working in engine tuning stations. An examination of heavy metals in blood and urine samples was done using plasma-optical emission spectrophotometer. The study found that there were insignificant differences in lead, nickel, and cadmium content of blood and urine samples in the group working in engine stations although they had higher antioxidant activity. The study concludes that workers exposed to heavy metals experience oxidative stress unrelated to heavy metal content in blood and urine.