1. Characterization and distribution of Mhc-DPB1 alleles in chimpanzee and rhesus macaque populations.
- Author
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Otting N, Doxiadis GG, Versluis L, de Groot NG, Anholts J, Verduin W, Rozemuller E, Claas F, Tilanus MG, and Bontrop RE
- Subjects
- Alleles, Animals, Base Sequence, China, Histocompatibility Testing, India, Molecular Sequence Data, Myanmar, Pongo pygmaeus genetics, Sequence Homology, Nucleic Acid, Gene Frequency, Genes, MHC Class II, Histocompatibility Antigens Class II genetics, Macaca mulatta genetics, Pan troglodytes genetics
- Abstract
Allelic diversity at the nonhuman primate Mhc-DPB1 locus was studied by determining exon 2 nucleotide sequences. This resulted in the detection of 17 chimpanzee (Pan troglodytes), 2 orangutan (Pongo pygmaeus) and 16 rhesus macaque (Macaca mulatta) alleles. These were compiled with primate Mhc-DPB1 nucleotide sequences that were published previously. Based upon the results, a sequence specific oligotyping method was developed allowing us to investigate the distribution of Mhc-DPB1 alleles in distinct chimpanzee and rhesus macaque colonies. Like found in humans, chimpanzee and rhesus macaque populations originating from different geographic backgrounds appear to be characterized by the presence of a few dominant Mhc-DPB1 alleles.
- Published
- 1998
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