1. Bioactive isoquinoline alkaloids from Cissampelos pareira † .
- Author
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Bala M, Kumar S, Pratap K, Verma PK, Padwad Y, and Singh B
- Subjects
- A549 Cells, Alkaloids isolation & purification, Antineoplastic Agents, Phytogenic isolation & purification, Aporphines, Humans, India, Isoquinolines isolation & purification, KB Cells, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Extracts chemistry, Plant Roots chemistry, Seasons, Alkaloids pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Cissampelos chemistry, Isoquinolines pharmacology
- Abstract
The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1-5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.
- Published
- 2019
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