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Can a mandate for inclusive school education translate into reality? What challenges can undermine it in the context of a stratified schooling system? We discuss this in the context of India's landmark Right to Education Act. A controversial clause of the Act mandates that private schools should reserve at least 25 percent of entry-level seats for disadvantaged sections of the society. This paper, drawing on a detailed survey of 1642 households, and interactions with parents over 2014-2019, unpacks the experiences of households who applied for admission in private schools through the mandate. Our results suggest that more resourceful households (in terms of ability to speak official language, wealth and education) are more likely to apply, and get admissions through the mandate. Acquiring eligibility documents (proofs for income and residence) is a major hurdle in completing the application process. Even after being allotted a seat, households continue to face several barriers that make it difficult for them to secure an admission and enrol or continue sending their child to the private school through the mandate. The results are sobering, and flag the possibility that transformative potential of the mandate may not be fully realised if the status quo prevails.

Mentoring and coaching are established best practices across the corporate world. These are designed to support leadership development, career progression and engaging select employees with a view to enhancing performance and achievement at the individual, group and organization level. However, such practices have not found wide adoption across the higher education sector, especially in developing countries such as India where it is still an alien concept. We present early results from a year-long mentoring program for 12 faculty members at a higher education institution in Jammu, India. Mentoring was found to have the best outcomes for early and mid-career faculty especially women and resulted in attainment of significant individual and institutional outcomes. This paper makes a strong case for the wide-adoption of faculty mentoring across higher education institutions in India subject to some caveats.

Background: Despite decades of a call to action to engage men in reproductive health, men are often left out of programs and interventions. In India, where half of pregnancies are reported as unintended, patriarchal gender norms and still dominant patterns of arranged marriages make engaging men in family planning and strengthening couples communication critical in increasing reproductive autonomy and helping young couples meet their reproductive goals. This study explores the feasibility and acceptability from the men's perspective of the pilot of a gender transformative intervention for newly married couples in India. Methods: A pilot study was conducted of TARANG, a 4 month intervention for newly married women, with light touch engagement of husbands (4 sessions). A total of 41 husbands participated in the pilot, and we collected baseline knowledge and endline feasibility and acceptability data from them, along with in depth qualitative interviews with 13 men. The study was conducted in June 2023-January 2024. Results: Men had low levels of knowledge about biology, family planning, with the majority of men reporting that no one had provided them information about these topics. Most men wanted to delay the first birth by at least 2 years, yet less than a quarter had discussed childbearing plans with their partner or engaged in family planning methods. While all men reported high acceptability (satisfaction and usefulness), feasibility (participation) was low, with only 43% attending 2 or more sessions. Main barriers to participation included commitments due to work and migration. Men reported that the intervention led to improvements in their relationships with their wives, gave them a sense of empowerment, and led them to become resources for other men in their community. Conclusions: Men in these rural communities are not receiving the information that they need to meet their reproductive goals, however, they greatly desire this information and ways to improve relationships with their new wives. Such an intervention appears to have the potential to help change norms and spread information in the community and provide men with positive, life affirming feelings. Providing information through technology could address barriers to in-person engagement. Trial registration clinicaltrials.gov : 03/13/24.NCT06320964 Plain language summary: Despite many years of calls to engage men in reproductive health programming, there are still a paucity of interventions that engage men. In the Indian context, with high prevalence of arranged marriages, strict gender norms, and patrilocal marriage patterns where women move into their husbands family's home, engaging men is especially important as they are critical decision-makers. With this in mind, we designed an intervention for newly married women, with an add on component for their husbands, to help young couples meet their reproductive goals. In this paper we report on the feasibility and acceptability of a 6 month pilot of this intervention with 40 newly married men in Rajasthan, India using mixed methods. We find that the intervention was highly feasibility and acceptable, and men felt that the intervention had value and should be considered. However, attendance was low due to work commitments and migration. The intervention appeared to change norms and increase knowledge about family planning and communication about childbearing. Men reported that the intervention led to improvements in their relationships with their wives, gave them a sense of empowerment, and led them to become resources for other men in their community. This suggests that engaging newly married men is possible, but interventions must be designed carefully to be sure to be able increase participation. [ABSTRACT FROM AUTHOR]

Can a mandate for inclusive school education translate into reality? What challenges can undermine it in the context of a stratified schooling system? We discuss this in the context of India's landmark Right to Education Act. A controversial clause of the Act mandates that private schools should reserve at least 25 percent of entry-level seats for disadvantaged sections of the society. This paper, drawing on a detailed survey of 1642 households, and interactions with parents over 2014–2019, unpacks the experiences of households who applied for admission in private schools through the mandate. Our results suggest that more resourceful households (in terms of ability to speak official language, wealth and education) are more likely to apply, and get admissions through the mandate. Acquiring eligibility documents (proofs for income and residence) is a major hurdle in completing the application process. Even after being allotted a seat, households continue to face several barriers that make it difficult for them to secure an admission and enrol or continue sending their child to the private school through the mandate. The results are sobering, and flag the possibility that transformative potential of the mandate may not be fully realised if the status quo prevails. [ABSTRACT FROM AUTHOR]

Childhood hypertension (HTN) is becoming one of the most important health concerns in children, and it is the most important predictor of adult HTN. The objective was to assess the level of knowledge and to develop and validate questionnaires about childhood HTN among final-year medical students. This facility-based cross-sectional study was conducted from January 2018 to September 2018 in 5 teaching hospitals of Central India. A total of 383 interviews were conducted by non-probability purposive sampling using a validated tool. Exploratory factor analysis was used to assess the validity of the questionnaire, and internal consistency of items was assessed with Cronbach α. A total of 26 items were finalized through consensus. The Kaiser–Meyer–Olkin (KMO) measure of sample adequacy was measures of sampling adequacy (MSA) = 0.83, and Bartlett's test of sphericity was (x2 = 15.89, P =.014). This study shows that the tool developed had acceptable validity and reliability to assess the knowledge about childhood HTN among undergraduate medical students. [ABSTRACT FROM AUTHOR]

Workplace mental health challenges have emerged as a significant concern post-pandemic. Despite this, the pervasive stigma surrounding mental illness leads to the concealment of symptoms and reluctance to seek professional help among employees. This study aims to explore the perception of different stakeholders towards the 'Detection and disclosure' of workplace mental health challenges in the Indian context. Fifteen semi-structured interviews were conducted with human resource professionals, counselors, and employees who had previously experienced mental health challenge(s). Thematic analysis was done to identify recurring themes and sub-themes. Three critical pathways were identified: minimizing the inhibitory factors, including lack of awareness, denial, low self-efficacy, stigma, and underestimating organizational capability; maximizing the encouraging factors, including psychological safety, perceived social support, and communicating success stories; and implementing supportive organizational practices, including generating awareness and literacy, build the organizational capability, strengthen the role of managers, leadership advocacy, policies, and processes. By fostering a culture of support and prioritizing employee well-being, organizations in India can create healthier and more resilient work environments, benefiting both individuals and the larger society. [ABSTRACT FROM AUTHOR]

Introduction: The use of continuous glucose monitoring (CGM) for in-hospital glucose control has been widely studied. However, its application in intensive care unit (ICU) settings is debatable owing to its perceived limitations. In ICU patients with diabetes, glycemic excursions, including frequent hypoglycemic episodes, are more prevalent. This retrospective study was undertaken to evaluate the utility of CGM in the management of diabetes patients admitted to the ICU. Methods: We collected data of patients with diabetes mellitus who were admitted to the ICU at our institution and were advised CGM by the intensivist. Aretrospective analysis was conducted, examining demographic, clinical, and laboratory data, along with glucose meter readings and CGM data. The results are presented as numbers, percentages, or median values, as appropriate. Results: Out of 65 patients in the ICU, the median values of percentage time in range, time below range, and time above range were 59%, 2%, and 36%, respectively. The median HbA1 C and capillary glucose on admission were 8.8% and 246 mg/dl, respectively. During the ICU stay, the CGM derived average glucose level was 167 mg/dl (percent coefficient of variation [%CV] =25.96) and the glucose management indicator was 7%. In total, 65 episodes of hypoglycemia were detected, all confirmed by capillary glucose tests. A total of 27 patients experienced hypoglycemia, of which 12 had nocturnal hypoglycemia. Conclusion: The use of CGM in the ICU improved glycemic control and helped to detect hypoglycemia, particularly nocturnal with acceptably low glycemic variability as measured by percentage CV. Further studies are required to corroborate and confirm these findings. [ABSTRACT FROM AUTHOR]

The present study attempts to obtain an a priori estimate of the absorbed dose received by an individual engaged in the reconnaissance survey in Uranium exploration using a predictive mathematical regression analysis. Other radiation safety parameters such as excess lifetime cancer risk are also calculated. Study reflects that the proper handling of naturally occurring radioactive materials accounts for an absorbed dose significantly less than the prescribed limit. [ABSTRACT FROM AUTHOR]

Contextualizing the void of research on inhalant abuse among adolescents as epistemic neglect, in this study, we use mixed‐methods action research to understand inhalant abuse in a specific context in the Global South. Focusing on a large metropolitan city in Western India, we surveyed 158 street‐involved children and adolescents (110 boys and 48 girls, age range from 5 to 17 years) in a group setting along with follow‐up group interviews. Despite finding a high prevalence rate of inhalant abuse, our work suggests an absence of supporting structures and emphasizes the need to revisit our understanding and interpretation of substance‐using behavior of street‐involved youth. Instead of explaining inhalant‐abusing behavior as emerging from pathological deficiencies in individuals or households, we stress the need to critically examine the exploitative environment they are embedded in. In doing so, we join efforts to decolonize conventional ways of understanding "deviant" behavior. [ABSTRACT FROM AUTHOR]

The present study is conducted to assess the radiological and hydrogeochemical quality of earthly bore potable water in Haridwar, Uttarakhand, India. Radon activity concentrations in water samples ranged from 0.59 ± 0.04 to 57.32 ± 4.39 Bq/L. The average activity concentration of radon is estimated as 10.46 ± 1.05 Bq/L. Annual Effective Inhalation dose to humans ranged from 1.48 μSv/Y to 144.45 μSv/Y with an average value of 26.36 μSv/Y. Ca2+ > Na+ > Mg2+ > K+ and HCO3− > CaCO3− > SO42− > Cl− > NO3− > F− were the concentration orders of the primary cations and anions. The majority of tests contained acceptable levels of ions and TDS, indicating that the region's groundwater is safe for consumption. For irrigation purposes, the sodium absorption rate, sodium percentage, and magnesium risks were examined. The weathering of rocks was discovered to be the key factor influencing the chemistry of the groundwater in the region. The spatial patterns of observed fluctuations were investigated using the collected data set. [ABSTRACT FROM AUTHOR]

Background: The limited representation from developing countries in the original COME TOGETHER survey gave us an impetus to conduct this survey in the Indian subcontinent. Methods: This cross-sectional online survey was conducted from August through September 2022. Participants were health care physicians caring for patients with coma and disorders of consciousness. Fischer's exact test or the Mann–Whitney U-test was used to compare respondents who agreed or disagreed with the preestablished coma definition. Fleiss κ values were calculated to assess agreement among respondents. A p value less than 0.05 was considered statistically significant. Results: The survey was completed by 130 physicians. We found substantial interrater agreement on absence of wakefulness (71.54%; κ = 0.71), Glasgow Coma Score ≤ 8 (78.46%; κ = 0.78), and failure to respond purposefully to visual, verbal, or tactile stimuli (66.15%; κ = 0.66). Reported common etiologies of coma included traumatic brain injury (50.76%), ischemic stroke (30%), and intracerebral hemorrhage (29.23%). The most common clinical assessment tools used for coma included the Glasgow Coma Score (92.3%) and neurological examination (60.8%). Neurological examination was the most common diagnostic tool used (100%), followed by magnetic resonance imaging (89.2%), basic laboratory studies (88.5%), and head computed tomography/angiography (86.9%). Pharmacological interventions used to stimulate arousal in patients with coma were sedation vacation (91.5%), electrolyte/endocrine correction (65.4%), osmotic therapy with mannitol (60%), hypertonic saline (54.6%), modafinil (46.9%), and antidote for drugs (45.4%). Among the nonpharmacological interventions, sensory stimulation (57.7%) was the most commonly used modality. The most common discharge disposition for comatose patients who survived hospitalization were home with or without services (70.0%). Conclusions: Differences from the global survey were noted regarding the following: traumatic brain injury being the most common etiology of coma in India, more frequent practice of sedation interruption, less frequent use of electroencephalography in India, rare use of pharmacological neurostimulants, and home being the most common discharge disposition in India. [ABSTRACT FROM AUTHOR]

This study examines 52 water samples from diverse locations in the Dehradun district, measuring radon activity concentrations with a scintillation-based monitor. The findings indicate an average concentration of 33.97 Bq/L, ranging from 3.35 to 99.25 Bq/L. Beyond this, the research estimates annual effective ingestion (µSv/y), inhalation (µSv/y), and total (µSv/y) doses attributed to radon in the drinking water samples, offering insights into potential health risks. Additionally, the study explores spatial patterns in the dataset, providing a geographic perspective on radon distribution across the region. This spatial analysis enhances our understanding of localised exposure risks, contributing valuable information for public health and environmental considerations in the Dehradun district. [ABSTRACT FROM AUTHOR]

This study focuses on investigating the release and dispersion of radon in diverse samples obtained from four designated sites (Rajpur, Maldevta, Kalsi and Dugadda) situated within the Main Boundary Thrust region of Garhwal Himalaya, Uttarakhand, India. In the Current research, we measured different radioactive parameters; including natural radioactivity (Radium content) and Mass exhalation rate. Using these measurements, we calculated the radon emanation fractions in 82 samples from four sampling sites. The radium content exhibited a range of 39 ± 8 Bq kg−1 to 442 ± 50 Bq kg−1, averaging at 88.2 ± 62.2 Bq kg−1. The Radon Exhalation rate displayed a range of 8.56 ± 3.1 mBq kg−1 h−1 to 144.9 ± 12.5 mBq kg−1 h−1 with an average rate of 48.4 ± 29.2 mBq kg−1 h−1. The variation in radon emanation fraction ranged from 0.62 to 8.52, with an average of 3.25 ± 1.60. Initially, the samples were categorized into rock and soil groups. To introduce an additional dimension, a secondary classification based on dry and wet conditions were subsequently incorporated. An increase in radon emanation fraction was observed for the wet samples due to higher moisture content. [ABSTRACT FROM AUTHOR]

The application of genomic technologies has led to unraveling of the complex genetic landscape of disorders of epilepsy, gaining insights into their underlying disease mechanisms, aiding precision medicine, and providing informed genetic counseling. We herein present the phenotypic and genotypic insights from 142 Indian families with epilepsy with or without comorbidities. Based on the electroclinical findings, epilepsy syndrome diagnosis could be made in 44% (63/142) of the families adopting the latest proposal for the classification by the ILAE task force (2022). Of these, 95% (60/63) of the families exhibited syndromes with developmental epileptic encephalopathy or progressive neurological deterioration. A definitive molecular diagnosis was achieved in 74 of 142 (52%) families. Infantile‐onset epilepsy was noted in 81% of these families (61/74). Fifty‐five monogenic, four chromosomal, and one imprinting disorder were identified in 74 families. The genetic variants included 65 (96%) single‐nucleotide variants/small insertion‐deletions, 1 (2%) copy‐number variant, and 1 (2%) triplet‐repeat expansion in 53 epilepsy‐associated genes causing monogenic disorders. Of these, 35 (52%) variants were novel. Therapeutic implications were noted in 51% of families (38/74) with definitive diagnosis. Forty‐one out of 66 families with monogenic disorders exhibited autosomal recessive and inherited autosomal dominant disorders with high risk of recurrence. [ABSTRACT FROM AUTHOR]

Background: Perianal fistulas (PF) affect one-third patients with Crohn's disease (CD) with limited therapeutic options. There is dearth of literature on safety and efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) in this population. Methods: An open-label, phase I/II, single-arm study was conducted involving local administration of human allogeneic bone marrow-derived mesenchymal stromal cells in perianal fistula of patients with Crohn's disease refractory to standard therapies. Clinical severity and biomarkers were assessed at baseline and periodically until week 104 , and MRI at week 24 and 104. Primary and secondary objectives were to assess safety and efficacy respectively. Fistula remission was complete closure of fistula openings with < 2 cm perianal collection on MRI, and fistula response was decrease in drainage by ≥ 50%. Change in perianal disease activity index, quality-of-life and Van Assche index on MRI over time was assessed using mixed-effect linear regression model. Results: Ten patients (male:8, mean age:27.4 ± 12.0years) were recruited. Self-resolving procedure-related adverse events occurred in three patients, with no follow-up adverse events. In intention to treat analysis at week 24, two patients (20%) achieved fistula remission and seven (70%) had fistula response. At week 52, two (20%) patients were in remission and seven (70%) maintained response. At 104 weeks, two (20%) patients maintained response and one (10%) was in remission. Statistically significant decrease in perianal disease activity index (P = 0.008), Van Assche Index (P = 0.008) and improvement in quality-of-life (P = 0.001) were observed over time. Conclusions: Allogeneic BMSCs are safe and effective for the treatment of perianal fistulizing CD with significant improvement in clinical severity and radiological healing. Trial registration: The study was prospectively registered on Clinical trials registry – India (CTRI), CTRI/2020/01/022743 on 14 January 2020, http://ctri.nic.in. [ABSTRACT FROM AUTHOR]

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Canine cognitive dysfunction syndrome is a common behavioural disorder of geriatric dogs prevailing in the world including India. The etiology is not confirmed yet, however, the main pathological change is age-related and progressive amyloid protein deposition in the brains of affected dogs. The syndrome usually goes unnoticed due to unawareness among caretakers and non-specific clinical signs such as altered behaviour and cognition. When detected early, environmental enrichment, nutritive diet and supportive therapeutic agents can be beneficial in procrastinating the disorder and improving the quality of life of the animal. [ABSTRACT FROM AUTHOR]

Background: In recent years, a significant understanding of delivering optimal aerosol therapy and the availability of various drugs and devices have led to an increase in its use in clinical practice. There are only a few studies available regarding their use in critically ill patients from a few parts of the world. We aimed to study the practice pattern of aerosol therapy in critically ill patients from Indian intensive care units (ICUs). Methods: After ethical approval, this multi-centric prospective observational study was performed over a study period of four weeks. Newly admitted adult patients considered who had an artificial airway and/or ventilation (including non-invasive). Patients were followed up for the next 14 days or until ICU discharge/death (whichever came first) for details of each aerosol therapy, including ongoing respiratory support, drug type, and aerosol-generating device. Results: From the nine participating centers across India, 218 patients were enrolled. Of 218 enrolled patients, 72.48% received 4884 aerosols with 30.91 ± 27.15 (95%CI: 26.6-35.1) aerosols per patient over 1108 patient days. Approximately 62.7% during IMV, 30.2% during NIV, 2.3% in spontaneously breathing patients with an artificial airway during weaning, and 4.7% were given without an artificial airway after weaning or decannulation. In 59%, a single drug was used, and bronchodilators were the most frequent. The jet nebulizer was the most common, followed by the ultrasonic and vibrating mesh aerosol generator. The ventilator setting was changed in only 6.6% of the aerosol sessions with IMV and none with NIV. Conclusion: Aerosol therapy is frequently used with a wide variation in practices; bronchodilators are the most commonly used drugs, and jet nebulizers are the most widely used. [ABSTRACT FROM AUTHOR]

Introduction: Enhanced recovery after surgery (ERAS) is a multidisciplinary approach to optimize patient care. The goal of this approach is to reduce the body's reaction to surgical stress by optimizing the perioperative nutritional status, promoting analgesia without opioids, and early postoperative feeding. In pediatric patients, very limited literature is available for the application of ERAS protocol. This study was done to evaluate the application of ERAS protocol in pediatric hepatobiliary and pancreatic patients. Materials and Methods: This is a randomized prospective study conducted over a period of 2 years at a tertiary center in North India. A total of 40 hepatobiliary and pancreatic patients who were willing to participate in the study were included in the study. Patients were randomized by computer-generated method and data were collected regarding demography, clinical diagnosis, preoperative and postoperative workup, and peri-operative care including analgesia, pain scores, postoperative recovery, hospital stay, and complications. These patients were followed for 6 months postoperatively and the results were evaluated using SPSS software. Results: The study included 20 patients each in both the conventional and ERAS group with median ages of 11.5 years and 7.1 years, respectively. The data analysis showed that the ERAS group of patients had better outcomes in terms of hospital stay and drain removal time with significant statistical differences. Pain scores and complications are almost the same in both groups. Conclusion: Principles of ERAS can be safely applied in pediatric patients undergoing major surgery in the present era of emerging infections and also increasing patient burden without morbidity. [ABSTRACT FROM AUTHOR]

COALESCE, a collaborative network studying the impacts of carbonaceous aerosols, measured PM2.5 mass and its constituents at several regionally representative sites in India. This study reconciles the reconstructed mass (RCM) from PM2.5 chemical constituents with gravimetric PM2.5 mass measured during 2019 at three COALESCE sites (Bhopal, Mesra, and Mysuru). To evaluate the extent of mass closure, the spatiotemporal variability of organic matter/organic carbon (OM/OC), filter sampling artifacts of OC, nitrate, and aerosol liquid water (ALW) were assessed. The annual loss of total particulate OC from Teflon filters varied across Bhopal (0.46–1.35 μg m−3), Mesra (0.30–0.92 μg m−3), and Mysuru (0.16–0.68 μg m−3). Likewise, the range of nitrate volatilization was 0.7–2.7 μg m−3 at Bhopal, 0.5–2 μg m−3 at Mesra, and 1.3–2.2 μg m−3 at Mysuru. Also, the range of ALW mass was 2.6–6.8 μg m−3 at Bhopal, 3.2–9.5 μg m−3 at Mesra, and 0.8–3.8 μg m−3 at Mysuru. Seasonality was observed in the value of OM/OC with an increase during the pre‐monsoon season at all sites viz., Bhopal (2.20), Mesra (1.61), and Mysuru (2.02) compared to their annual averages, suggesting enhanced contribution of secondary organics to OC. The method developed for estimating RCM in this study resulted in better mass closure compared to using conventional RCM algorithms. Overall, this study provides a robust data validation strategy and India‐specific species coefficients for use in the RCM algorithm. The outcomes of this study can guide regional aerosol sampling, chemical analyses, and model–measurement reconciliation efforts. Plain Language Summary: This work investigates the relationships between surface PM2.5 and its chemical constituents across three locations in India through a mass closure investigation. The study enhances traditional mass reconstruction methodology by accounting for residual aerosol liquid water and volatilization losses of nitrates and organics, as well by using seasonal coefficients in the reconstruction algorithm. The seasonality of the volatilization losses and value of OM/OC provide insights on primary and secondary organic carbon across the sites. The application of seasonal coefficients improved the agreement between the RCM (reconstructed PM mass from chemical species) and PM2.5. Overall, this study provides a better understanding of the relationship between surface PM2.5 and its chemical constituents in India and will help guide sampling and chemical speciation efforts for aerosol mass apportionment. [ABSTRACT FROM AUTHOR]

Background Hereditary angio-oedema (HAE) is a rare autosomal dominant disorder characterized clinically by recurrent episodes of nonpruritic subcutaneous and/or submucosal oedema. Laryngeal oedema is the commonest cause of mortality in patients with HAE. Prior to the availability of first-line treatment options for the management of HAE, mortality was as high as 30%. Mortality has significantly declined in countries where first-line treatment options are available and patients can access these therapies. There is a paucity of literature on the outcomes of patients with HAE in developing countries where availability of and access to first-line treatment options are still a challenge. Objectives To report our experience on mortality in patients with HAE and to report factors associated with the death of these patients. Methods We carried out a record review of all patients diagnosed with HAE between January 1996 and August 2022. Families with HAE who had reported the death of at least one family member/relative from laryngeal oedema were studied in detail. Results Of the 65 families (170 patients) registered in the clinic, 16 families reported the death of at least one family member/relative from laryngeal oedema (total of 36 deaths). Of these 16 families, 14 reported that 1 or more family members had experienced at least 1 attack of laryngeal oedema. One patient died during follow-up when she was taking long-term prophylaxis with stanozolol and tranexamic acid, while the remaining 35 patients were not diagnosed with HAE at the time of their death. At the time of death of all 36 patients, at least 1 other family member had symptoms suggestive of HAE, but the diagnosis was not established for the family. Conclusions To our knowledge, this is the largest single-centre cohort of patients with HAE in India reporting mortality data and factors associated with death in these families. The delay in diagnosis is the most important reason for mortality. [ABSTRACT FROM AUTHOR]

Adoption of "Industry 4.0" technologies in construction is rising in recent years due to intervention of government and non government bodies for combating environmental challenges. In order to understand various enablers that influence "adoption of Industry 4.0" – technologies, this study is conducted for assessing degree of enablers in Indian construction. A hybrid MCDM approach using – Fuzzy SWARA and Fuzzy COPRAS named as ARank-FSC is proposed. Fuzzy "SWARA" aids in obtaining relative weights of enablers while COPRAS helps in ranking and selecting most efficient amongst them. The proposed approach is applied on a case organization engaged in construction. Results indicate that profitability acts as top ranked enabler that would significantly affect "Industry 4.0" acceptance in Indian construction. Stakeholders coordination, Governmental regulations, strategic planning, building information modeling and risk taking behavior are also critical enablers that significantly affect acceptance of "Industry 4.0" technologies in construction industry of developing countries like India. The present study aims to analyze-the-rank of enablers-in "adoption-of-Industry-4.0". The proposed approach is put through a sensitivity analysis to determine its robustness. This research's conclusions and ramifications-will-be-useful-to-practitioners-and-researchers-in-understanding degree of enablers for implementation-of-Industry 4.0-in-construction-industries of developing countries like India. [ABSTRACT FROM AUTHOR]

Background: Seed processing workers are exposed to dust particles generated during the processing of seeds, which can have adverse effects on their respiratory health. Aim: to estimate the prevalence and patterns of respiratory morbidity among seed processing workers in Hooghly district, West Bengal, India, and to explore their use of respiratory personal protective equipment (PPE). Methods: A cross sectional observational study was conducted in 5 seed processing plants from December 2022 to February 2023. A sample size of 129 workers was selected using probability proportionate to population size to select seed processing plants and simple random sampling to select workers at selected plants. Data on sociodemographic characteristics, occupational profile, substance use patterns, respiratory PPE use, and respiratory symptoms were collected through structured interviews. Spirometry was performed with a hand held tabletop spirometer (RMS Helios 401) to assess respiratory function. Results: 52.7% of participants reported at least one chronic respiratory symptom, while 17.1% had evident respiratory morbidity based on spirometry results, with most having restrictive patterns (10.1%). Multivariable regression analysis revealed that factors associated with respiratory morbidity included increasing work years of exposure [1.10 (1.02 1.18)], irregular use of respiratory PPE [4.36 (1.22 15.57)], and primary or below education level [6.09 (1.38 26.98)]. Conclusion: The study highlights the high prevalence of respiratory symptoms and morbidity among seed processing workers. It emphasizes the importance of implementing effective respiratory protection measures and raising awareness about occupational lung diseases in this industry. Further research and interventions are needed to improve the respiratory health and well being of seed processing workers. [ABSTRACT FROM AUTHOR]

Mental retardation, characterized by impaired intellectual functioning and adaptive behaviour, often involves chromosome anomalies. While conventional karyotyping detects some anomalies, a significant portion remains undetected due to limitations in resolution. Array-based Comparative Genomic Hybridization (aCGH) provides higher resolution and is increasingly used for diagnosis. This study aims to assess CNVs in children with intellectual disabilities using aCGH. Fiftyfour children with intellectual disabilities were selected and blood samples were obtained. DNA was extracted and analyzed using aCGH. The study was conducted at Banaras Hindu University, India, following ethical guidelines. 54 samples, 38 showed abnormal karyotypes. The remaining 16 underwent aCGH, revealing CNVs across various chromosomes. CNVs impacted genes associated with neurodevelopmental disorders (e.g., FCGR3B, CFHR3, CFHR1), immune response (e.g., HLA-DRB6, HLA-DRB1, HLA-DQA1) and metabolic pathways (e.g., UGT2B17). Chromosomes 1, 9 and 21 exhibited multiple CNVs, suggesting their involvement in intellectual disability. In conclusion, this study underscores the genetic complexity of intellectual disability, highlighting the importance of CNV analysis for diagnosis and understanding disease pathogenesis. Further research and larger-scale studies are needed to elucidate the specific contributions of CNVs to intellectual disability and inform clinical management and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Dewatered sludges from twenty-two sewage treatment facilities were characterized to develop the quality control indices in India. This study used fertilizer index (FI) and clean index (CI) as a tool for categorizing sludge utilization into different classes (A, B, C and limited use classes LU-1, LU-2, LU-3) by their fertilizing potential, toxicity level, pathogen presence, and vector attraction reduction criteria. The findings revealed that total P (as P2O5), total N, and K (as K2O) in the sludge samples ranged from 0.9 to 5.7%, 1.2 to 3.8%, and 0.1 to 1.5%, respectively. Moreover, all sludges belong to Class C and lower category due to the presence of toxic metals and pathogens. The helminth eggs were found in the range of 25–1450 Numbers/4gTS in sludge samples. The highest number of helminth eggs of 1450/4 g of TS was found in the fecal sludge. The specific oxygen uptake rate (SOUR) values in the sludge samples varied from 0.3 to 4.9, with a median value of 1.3 and an RSD of 86% is way too high. It indicates that the sludge samples need further treatment to be less attractive as a food source for vectors and rodents. However, sludge samples have fertilizing potential and FI values ranges from 4.1 to 4.9, and CI value ranges from 2.5 to 5.0. It indicates that compost is best in quality and has high-fertilizer potential and low heavy-metal content, which is suitable for high-value crops such as organic farming. Further sludge treatment using typical composting, aerobic or anaerobic digestion, and solar or thermal drying could bring the sludges into the Class A and B categories. [ABSTRACT FROM AUTHOR]

Background Dedicator of cytokinesis protein 8 (DOCK8) deficiency is an autosomal recessive form of combined immunodeficiency. This rare disorder is characterized by an increased predisposition to allergy, autoimmunity and malignancies. Objectives To analyse clinical, immunological and molecular profiles of patients with DOCK8 deficiency. Methods Clinic records of all patients attending the primary immunodeficiency clinic from 2018 to 2021 were reviewed. Six patients from five families were found to have DOCK8 deficiency. Results Median age at diagnosis was 7.5 years (range 2–13), with a male/female ratio of 5 : 1. Among the six patients, recurrent eczematous skin lesions were the predominant cutaneous manifestation, present in five patients (83%). Warts and molluscum contagiosum were evident in two patients (33%) and one patient (16%), respectively. Two patients had recalcitrant prurigo nodularis lesions and two had epidermodysplasia verruciformis-like lesions. Food allergies and asthma were reported by one patient each. Of the six patients, recurrent sinopulmonary infections were detected in five (83%). Epstein–Barr virus-driven non-Hodgkin lymphoma with liver metastases was the only case of malignancy, in a 4-year-old boy. IgE was elevated in all patients. Lymphopenia and eosinophilia were observed in three patients (50%) and five patients (83.3%), respectively. Genetic analysis showed DOCK8 pathogenic variants in all patients: homozygous deletion mutations in two patients, compound heterozygous deletion mutations in one, and homozygous nonsense mutations in two. A novel pathogenic homozygous missense variant in the DOCK8 gene was identified in one patient. Conclusions DOCK8 deficiency should be considered as a possibility in any patient with early onset eczema, cutaneous viral infections and increased predisposition to allergy, autoimmunity and malignancy. [ABSTRACT FROM AUTHOR]

Objective Severe acute respiratory syndrome coronavirus 2 is a highly contagious respiratory viral infection that affects all individuals, although neonates are considered to be the most susceptible populations; therefore, this study was conducted to evaluate the clinical outcome and association between coronavirus disease 2019 (COVID-19)-positive mothers and newborns. Methods This cross-sectional study was conducted at a dedicated COVID-19 tertiary care hospital in India over a period of 1 year. The pregnant mothers infected with COVID-19 virus were enrolled with their newborn baby up to the age of 28 days. COVID-19 test was done by using a rapid antigen kit and further confirmed by reverse-transcription polymerase chain reaction. Results Prevalence of COVID-19-positive newborns born of COVID-19-positive mothers is reported at 8.4%. Female:male ratio was found to be 1:1.2. Raised D-dimer (88.9%) and C-reactive protein (88.9%) were the most common findings in COVID-19-positive newborns followed by leucopenia (33.3%). Among the COVID-19 newborns, Apgar score less than or equal to 7 and respiratory distress were found in 55.6 and 33.3%, respectively. Out of 9 COVID-19-positive newborns, two (22.2%) were expired, and out of 98 COVID-19-negative newborns, 4(4.1%) were expired. Conclusion This study revealed that severity of maternal symptoms is related to mortality of newborns. About 22.2% COVID-19-positive newborns expired, whereas 4.1% of COVID-19-negative newborns expired so risk of mortality increased among COVID-19-positive neonates as compared with negative ones. However, this study was conducted on a small sample size and further research with larger populations is needed to validate these findings. [ABSTRACT FROM AUTHOR]

Imaging spectroscopy offers great potential to characterize plant traits at fine resolution across broad regions and then assess controls on their variation across spatial resolutions. We applied permutational partial least‐squares regression to map seven key foliar chemical and morphological traits using NASA's Airborne Visible/Infrared Imaging Spectrometer‐Next Generation (AVIRIS‐NG) for six sites spanning a climatological gradient in the Western Ghats of India. We studied the variation of trait space at spatial resolutions from the plot level (4 m), community level (30 and 100 m) to the ecosystem level (1,000 m). We observed a consistent pattern of trait space across different resolutions, with one axis defined by foliar nitrogen and leaf mass per area (LMA) and another axis representing leaf structure and defense defined by fiber, lignin, and total phenolics. We also observed consistent directionality of environment‐trait correlations across resolutions with generally higher predictive capacity of our environment‐traits models at coarser resolutions. Among the seven traits, total phenolics, fiber, and lignin were strongly influenced by environmental factors (model R2 > 0.5 at 1,000 m). Calcium, sugars, and nitrogen were significantly affected by site conditions, incorporating site as a fixed effect largely improved model performance. LMA showed little dependence on environmental factors or site conditions, suggesting a stronger influence of species composition and site history on LMA variation. Our results show that reliable trait‐trait relationships can be identified in coarse resolution imagery, but that local scale trait‐trait relationships (resolutions finer than 30 m) are not sensitive to broad‐scale abiotic/biotic factors. Plain Language Summary: We combined field leaf measurements and airborne hyperspectral images to map seven key foliar functional traits across the Western Ghats in India. We analyzed the traits at different spatial resolutions, from plot‐level (4 m), community level (30 and 100 m) to ecosystem‐level (1,000 m). We found that the trait‐trait relationship remains the same at different resolutions, which shows that we can learn a lot about the trait relationships by using images that aren't very detailed. We also looked at how traits are linked to the environment. Traits like chemicals that help plants defend themselves, as well as physical defenses like fiber and lignin, were strongly influenced by broad climate conditions. We could predict these traits well at 1,000 and 100 m. Other traits like calcium, sugars, and nitrogen were more affected by where the plants were growing, and we could predict them well when we considered the specific location. However, leaf mass per area didn't seem to depend much on the environment or location, which means it's probably influenced more by species composition and site history. When we looked at traits on a finer scale (30 m), our predictions weren't as accurate, suggesting that other things might also be affecting traits at those levels. Key Points: We mapped seven key plant functional traits for six sites along the Western Ghats of India‐a diverse but under‐represented areaOur study showed that the trait‐trait relationship (or trait space) is well conserved during the spatial aggregation from 4 to 1,000 mMost traits could be predicted well at 1,000 m and moderately at 100 m by environmental parameters but not at local scales finer than 30 m [ABSTRACT FROM AUTHOR]

As the British expanded their dominions in India, political and administrative needs made it imperative for them to acquire more information about their subjects. Hence, systematic and meticulous surveys began to be commissioned by the East India Company as it assumed charge of educating the natives. These surveys were an integral part of what Bernard Cohn has called the "documentation project" whose ultimate object was to control and subjugate the colonial subjects. Therefore, a key purpose of instituting educational surveys was to dismiss indigenous education and justify its supersession by colonial education. In the process, much of the information acquired by the colonial state was simplified and digested into a monolithic narrative. This article shows that regardless of the imperatives that influenced it, the colonial survey sometimes revealed fascinating details about the nature of indigenous institutions that were often overlooked by the British Governors General. As a case study, this article examines a set of enquiries instituted by the governments of Madras, Bombay, and Bengal in 1822, 1824, and 1835 respectively. By re-examining the reports submitted by district collectors in response to these government enquiries, this article seeks to challenge colonial notions about indigenous education. One of the principal aims of this article is to refute the charge that indigenous schools did not impart any moral or useful instruction. In doing so, the article also aims to highlight the instruction that was imparted in indigenous schools.

Petrological and major-trace element mineral chemistry studies have been carried out on pyroxenites from the Pakkanadu alkaline-ultramafic complex from the southern India to understand their origin and nature of magma responsible for ultramafic magmatism in the area. Pyroxenites display cumulus texture and consist of clinopyroxenes (cpx) and amphiboles (amp) as dominant phases with a subordinate amount of apatite, biotite, ilmenite, magnetite, pyrite, sphene, and calcite. Mineral chemistry classifies cpx as augite and diopside, whereas amp falls under tremolite-actinolite and hornblende- actinolite fields. Cpx are alkaline to sub-alkaline in composition and Mg# -- Al2O3 compositions suggest their crystallization under high-pressure conditions. A negative correlation between Mg# and TiO2 in cpx suggests early crystallization of magnetite and pyrite; high Mg# (76-92) suggests its link with the Alaskan- type intrusions, which may be crystallized through fractionation-accumulation Processes. Tectonic discrimination diagrams for cpx argue for the magmatic emplacements underan arc-tholeiitic environment in a subduction zone setting. Amp mineral chemistry (high SiO2 and low TiO2) indicate as the products of hydrothermal alteration of clinopyroxenes. A Low Al/Si ratio in the cpx suggests their derivation from silica-oversaturated magma, whereas low-Ti contents reflect slow cooling rate of the magma. Positive Rb, Ba and U anomalies in the multi-element patterns of the cpx probably signifying varying degrees of hydrothermal alteration in the studied samples. However, consistent Nb-Ta depletion can also be attributed to an enriched mantle source of the magma from which pyroxenites were crystallized. Moreover, single-cpx geothermobarometry yielded a crystallization temperature of 905 to 911°C under moderate to high pressure of 3-9 kbar. [ABSTRACT FROM AUTHOR]

Background and Objectives: In India, it is estimated that there are 40 million people suffering from Hepatitis B virus (HBV). Quantification of the viral burden is an important laboratory tool in the management. However, widespread use of different HBV-DNA assays is still affected by the high cost and variable diagnostic precision. The present study was conducted to evaluate the diagnostic precision and co-relation of ALT levels with HBV-DNA by Truenat®-PCR. Materials and Methods: In this prospective cross-sectional study a total of 567 serums were collected from patients by rapid HBsAg, and processed for liver function tests (LFT). The viral HBV-DNA amplification detection was carried out through by Truenat®-PCR test. Results: Out of 567 samples, 452 samples were found to be positive by both rapid and Truenat®-PCR and 106 were negative for HBV-DNA followed by 9 invalid. High ALT level found in 73% of positive patients who had HBV-DNA level (>100000 copies/ml) which is significantly higher in 447 patients as compared to those have below Ā100000 copies/ml. Conclusion: Truenat®-PCR technique is a highly sensitive and can be performed with low resources for effective control of HBV infection. Evaluation of HBV-DNA levels and serum ALT levels showed a significant proportion of patient harbored ongoing viral replication and disease progression. [ABSTRACT FROM AUTHOR]

We present the Monsoon Mission Coupled Forecast System version 2.0 (MMCFSv2) model, which substantially upgrades the present operational MMCFSv1 (version 1) at the India Meteorology Department. The latest 25 years (1998–2022) of retrospective seasonal coupled hindcast simulations of the Indian summer monsoon with April initial conditions from Coupled Forecast System Reanalysis are discussed. MMCFSv2 simulates the tropical wind, rainfall, and temperature structure reasonably well. MMCFSv2 captures surface winds well and reduces precipitation biases over land, except over India and North America. The dry bias over these regions remained like in MMCFSv1. MMCFSv2 captures significant features of the Indian monsoon, including the intensity and location of the maximum precipitation centers and the large-scale monsoon circulation. MMCFSv2 improves the phase skill (anomaly correlation coefficient) of the interannual variation of Indian summer monsoon rainfall (ISMR) by 17 % and enhances the amplitude skill (normalized root mean square error) by 20 %. MMCFSv2 shows improved teleconnections of ISMR with the equatorial Indian and Pacific oceans. This 25-year hindcast dataset will serve as the baseline for future sensitivity studies of MMCFSv2. [ABSTRACT FROM AUTHOR]

Entrepreneurship development is central to socio-economic growth in both developed and developing countries. In the case of India, it is a stated national policy to promote startups and kindle the entrepreneurial spirit among the youth. Else, there is a risk of the demographic dividend becoming a liability. Several states in India have made remarkable progress in this domain resulting in an established ecosystem for entrepreneurship development and support. Jammu and Kashmir, the northernmost region in the nation, also needs to emulate such successful models while leveraging government policies designed to support entrepreneurship. This exploratory study therefore examines the attitudes and perception of students in higher technical education towards entrepreneurship and choosing it as a career option. We conclude that government agencies, technical institutions, universities, schools, industry, and professional bodies need to come together with a viable action plan based around awareness, customized programs, deep engagement, handholding, mentoring and support for young students to see real outcomes on the ground. [ABSTRACT FROM AUTHOR]

Indian Higher Education is rapidly transforming with a national mission to improve quality and attain enhanced outcomes. Faculty is the bedrock of all institutional transformation initiatives. Faculty development has thus received significant attention from policy makers with several national initiatives in the offing. However, faculty support, engagement and true empowerment has not received the desired attention in a large majority of the institutions in the Indian Higher Education space. Apart from institutional commitment to building faculty engagement, an entire supporting ecosystem is required to create a culture of sustained performance leading to measurable outcomes. During the Covid-19 pandemic, online platforms for facilitating employee engagement gained traction across several industry verticals, a trend which has continued in the post-pandemic world. We present a case study on implementing an Enterprise Social Network (ESN) at an educational institution in India for building faculty engagement. Initial results establish the effectiveness of Enterprise Social Networks for facilitating information flow, communication, sharing success stories and recognition, besides effectively chronicling events, activities, and achievements. We recommend adoption of such platforms, subject to some caveats. [ABSTRACT FROM AUTHOR]

This study was carried out to evaluate the effectiveness of partial and full vaccination with ChAdOx1 nCoV-19 (COVISHIELD) to prevent the development of moderate or severe illness among COVID-positive cases. This prospective cohort study was conducted among Armed Forces personnel deployed in Northern India who were found COVID positive during the study period between January and June 2021. Information about the vaccination status, age and comorbidities was collected at the time of diagnosis. Classification of COVID cases as moderate or severe was performed as per criteria given by the Government of India. Individuals were considered partially vaccinated three weeks after one dose and fully vaccinated two weeks after the second dose. Risk ratio and vaccine effectiveness (VE) to prevent moderate or severe disease among COVID cases were calculated. A total of 2005 COVID-19 patients were included in our study. Partial vaccination and full vaccination with ChAdOx1 nCoV-19 offered 13% (95% credible interval (CI): −56.8%, 52.8%) and 66.6% (95% CI: 34.9%, 84.6%) protection against progression to moderate/severe illness among COVID-positive individuals. The risk of moderate-severe disease among COVID-positive cases occurring 4–11 weeks after the first dose was also lesser among those who had taken the second dose of vaccine than individuals who have been vaccinated with only one dose. Interval between the first and second doses of ChAdOx1 nCoV-19 vaccine should be reduced to 4–6 weeks, as partial vaccination offers lower protection against the development of moderate-severe illness after COVID infection. [ABSTRACT FROM AUTHOR]

To highlight the clinical presentations and management outcomes of rhino-orbital mucormycosis during first wave of COVID-19 pandemic in North India. A retrospective observational study. 15 patients with mucormycosis (orbital disease) who presented during short span of 3 months (October–December 2020) in a tertiary-care referral institution were analysed. At presentation, 13 of 15 patients had uncontrolled diabetes. Four had history of COVID-19 infection. All patients had advanced orbital disease with sinusitis; cavernous sinus involvement was in nine and intracranial spread in three patients. Liposomal amphotericin-B was started and prompt orbital exenteration with sinus surgery was performed in 12 patients. All 12 patients survived with an average follow-up of 4.8 months. In the present series, cases with orbital spread of mucormycosis were mostly found in non-COVID uncontrolled diabetics. Exenteration was done in 80% of cases with advanced orbital disease. Prevention and early detection of infection at the stage of sino-nasal involvement might help to prevent spread and/or halt the orbital disease. [ABSTRACT FROM AUTHOR]

Background: SARS-CoV-2 infections caused mild-to-moderate illness. However, a sizable portion of infected people experience a rapid progression of hyper-inflammatory and hypoxic respiratory illness that necessitates an effective and safer remedy to combat COVID-19. Methods: A total of 150 COVID-19-positive patients with no to mild symptoms, between the age groups 19–65 years were enrolled in this randomized, open-labeled three-armed clinical trial. Among them, 136 patients completed the study with RT-PCR negative reports. The patients received herbal drugs orally (Group A (Adhatoda vasica; AV; 500 mg; n = 50); Group B (Tinospora cordifolia; TC; 500 mg; n = 43), and Group C (AV + TC; 250 mg each; n = 43)) for 14 days. Clinical symptoms, vital parameters, and viral clearance were taken as primary outcomes, and biochemical, hematological parameters, cytokines, and biomarkers were evaluated at three time points as secondary outcomes. Results: We found that the mean viral clearance time was 13.92 days (95% confidence interval [CI] 12.85–14.99) in Group A, 13.44 days (95% confidence interval [CI] 12.14–14.74) in Group B, and 11.86 days (95% confidence interval [CI] 10.62–13.11) days in Group C. Over a period of 14 days, the mean temperature in Groups A, and B significantly decreased linearly. In Group A, during the trial period, eosinophils, and PT/INR increased significantly, while monocytes, SGOT, globulin, serum ferritin, and HIF-1α, a marker of hypoxia reduced significantly. On the other hand, in Group B hsCRP decreased at mid-treatment. Eosinophil levels increased in Group C during the treatment, while MCP-3 levels were significantly reduced. Conclusions: All the patients of the three-armed interventions recovered from COVID-19 and none of them reported any adverse effects from the drugs. Group C patients (AV + TC) resulted in a quicker viral clearance as compared to the other two groups. We provide the first clinical report of AV herbal extract acting as a modifier of HIF-1α in COVID-19 patients along with a reduction in levels of ferritin, VEGF, and PT/INR as the markers of hypoxia, inflammation, and thrombosis highlighting the potential use in progression stages, whereas the TC group showed immunomodulatory effects. Trial registration Clinical Trials Database -India (ICMR-NIMS), CTRI/2020/09/028043. Registered 24th September 2020, https://www.ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=47443&EncHid=&modid=&compid=%27,%2747443det%27 [ABSTRACT FROM AUTHOR]

Objective: To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health facility. Methods: Patients suffering from SARS-CoV-2 infection during the second wave of the COVID-19 pandemic in India (January-June 2021) at a tertiary care teaching hospital and level 2 COVID care facility were included. Cases who suffered from SARSCoV-2 infection but did not develop pneumothorax were selected as matched controls. All details regarding demographics, clinical presentation, treatment, and outcome were recorded in a semistructured proforma. Results: Eleven patients with COVID-19 developed pneumothorax during the study period and 40 controls were included in the study. Five cases were smokers in comparison to only two in the control group. Type 2 diabetes mellitus was the most common comorbidity among both groups. Median change in C-reactive protein overall for cases and controls were around +14.0 and - 41.9 and was statistically significant. Conclusions: Inflammatory markers like C-reactive protein have significant correlations with the development of pneumothorax in COVID-19-infected patients. There is no sex predisposition to develop pneumothorax among patients with COVID-19. [ABSTRACT FROM AUTHOR]

Water scarcity has become a permanent feature in Himalayan cities. Despite the recurrent events of the water crisis in Himalayan cities, the relationship between urban space and water scarcity has not received sufficient attention in the urban studies literature in India. Water scarcity is rooted both in the water infrastructure inherited during the precolonial and colonial periods meant for the population of that time and the resulting racial exclusionary practices. In the context of countries like India, or what we collectively call Southern Urbanisation, whenever there is a water crisis, the water infrastructure built during the colonial period is blamed solely for the crisis without considering the historicity of the production of these infrastructures within the urban space. Colonialism is a significant factor in understanding urbanisation in the Indian context, it is still prominent, even more so in the context of mountain urbanisation in India, where many new urban centers like Shimla, Darjeeling, and Murry emerged as the new centers of colonial domination in the second half of the nineteenth century. The urban space of the region is both a socio-temporal space produced through colonialism and a geographically contingent place. Therefore water scarcity needs to be analysed by combining these two factors. In this paper, I will contextualise water scarcity in the context of Himalayan urbanisation where the production of urban space is intertwined with the case of Shimla. The case study of the spatial development of Shimla shows how the urban space in Himalaya and its relationship with water scarcity require a separate field of inquiry within urban studies in the global south. [ABSTRACT FROM AUTHOR]

The Met Office Global Coupled Model (GC) and the NCEP Climate Forecast System (CFSv2) are both widely used for predicting and simulating the Indian summer monsoon (ISM), and previous studies have demonstrated similarities in the biases in both systems at a range of time scales from weather forecasting to climate simulation. In this study, ISM biases are studied in seasonal forecasting setups of the two systems, in order to provide insight into how they develop across time scales. Similarities are found in the development of the biases between the two systems, with an initial reduction in precipitation followed by a recovery associated with an increasingly cyclonic wind field to the north-east of India. However, this occurs on longer time scales in CFSv2, with a much stronger recovery followed by a second reduction associated with sea surface temperature (SST) biases, so that the bias at longer lead times is of a similar magnitude to that in GC. In GC, the precipitation bias is almost fully developed within a lead time of just eight days, suggesting that carrying out simulations with short time integrations may be sufficient for obtaining substantial insight into the biases in much longer simulations. The relationship between the precipitation and SST biases in GC seems to be more complex than in CFSv2, and is different during the early part of the monsoon season from during the later part of the monsoon season. The relationship of the bias with large-scale drivers is also investigated, using the Boreal Summer IntraSeasonal Oscillation (BSISO) index as a measure of whether the large-scale dynamics favours increasing, active, decreasing or break monsoon conditions. Both models simulate decreasing conditions the best and increasing conditions the worst, in agreement with previous studies and extending these previous results to include CFSv2 and multiple BSISO cycles. [ABSTRACT FROM AUTHOR]

Most dynamical models under-predict Indian summer monsoon rainfall (ISMR) variability despite showing greater dependency on external forcings in comparison with observations. In this study, we first highlight the observed patterns of externally forced rainfall variability over the Indian Ocean during boreal summer and then investigate the mechanisms involved in reduced variability in May initialized reforecasts from a multi-model dataset. The principal component analysis reveals a quad-polar structure in the first two modes of rainfall variability. It is shown that the first mode is driven by ENSO and IOD, while the second mode is independent of ENSO and is mainly driven by IOD. The differential response of ISMR to the ENSO and IOD is related to the difference in the phase relationship of the pole nearest to the Indian landmass with the rest of the poles of the quad-polar EOFs. This difference is found to be associated with the distinct response of winds over India to the ENSO and IOD forcings despite having similar zonal and meridional structures of modes of rainfall variability over the oceanic regions. The models capture the mode-1 spatial structure and temporal variations reasonably well due to high ENSO skill and realistic simulation of ENSO-rainfall teleconnections patterns, except for the Indian monsoon. The reduced skill in capturing the mode-2 structure is found to be related to low skill in simulating atmospheric and oceanic indices of IOD variability. The analysis shows that the reduced rainfall variability in models is due to the subdued response of the atmosphere to the climate modes. In comparison with observations, ENSO-mediated changes on upper tropospheric velocity potential and the meridional thermal gradients are weaker in models. This results in reduced ENSO-forced inter-annual variations of monsoon circulation and Indian rainfall. Southeast equatorial Indian Ocean (SEEIO) emerges as a key area of model deficiency where southeasterlies associated with both ENSO and IOD are underrepresented in the models. By highlighting the pathways associated with reduced rainfall variability, such studies could help in identifying the teleconnections which need to be improved in climate models. [ABSTRACT FROM AUTHOR]

Objectives: Recent advancement in understanding neurological disorders has revealed the involvement of dysbiosis of the gut microbiota in the pathophysiology of Parkinson's disease (PD). We sequenced microbial DNA using fecal samples collected from PD cases and healthy controls (HCs) to evaluate the role of gut microbiota. Methods: Full-length bacterial 16S rRNA gene sequencing of fecal samples was performed using amplified polymerase chain reaction (PCR) products on the GridION Nanopore sequencer. Sequenced data were analyzed using web-based tools BugSeq and MicrobiomeAnalyst. Results: We found that certain bacterial families like Clostridia UCG 014, Cristensenellaceae, and Oscillospiraceae are higher in abundance, and Lachinospiracea, Coriobacteriaceae and genera associated with short-chain fatty acid production, Faecalibacterium, Fusicatenibacter, Roseburia and Blautia, are lower in abundance among PD cases when compared with the HC. Genus Akkermansia, Dialister, Bacteroides, and Lachnospiraceae NK4A136 group positively correlated with constipation in PD. Conclusion: Observations from this study support the other global research on the PD gut microbiome background and provide fresh insight into the gut microbial composition of PD patients from a south Indian population. We report a higher abundance of Clostridia UCG 014 group, previously not linked to PD. [ABSTRACT FROM AUTHOR]

During the summer monsoon season, the Indian region experiences prominent south-westerly winds that extend up to the Philippines. These south-westerly winds encounter the Western Ghats (WG) and Deccan Plateau (DP). Many studies have discussed the role of WG in modulating the monsoon flow, convection and rainfall over the Indian region. However, the orographic influence of south-west orography (DP and WG both) on large-scale monsoon circulation remains unexplored. An experimental global model simulation was conducted with removed DP and WG orography to investigate this. The results showed that modifying the orography can alter the wind flow across the Philippines, Western North Pacific, and Bay of Bengal, leading to mid-tropospheric heating changes due to the monsoon trough position over these regions. This change in the monsoon trough position results in the stationary Rossby wave. The stationary Rossby wave generated strengthened winds over the south Bay of Bengal (BoB), which merges with the Philippine anticyclone over the Western North Pacific. The dynamical and thermodynamical changes are observed near Western North Pacific. Consequently, there is an increase in rainfall over the Western North Pacific and a decrease in rainfall over India. This study also found that the change in the monsoon flow affects the low-pressure systems and tropical cyclones. This work highlights how the South-West Indian orography affects the monsoon flow and synoptic variability across India, the West North Pacific, and the Philippines anticyclone. Thus, understanding the monsoon flow over the orography will help understand the dynamics. [ABSTRACT FROM AUTHOR]

Chronic granulomatous disease (CGD) is a phagocytic defect characterized by recurrent bacterial and fungal infections. We report clinical profile of patients with CGD and mycobacterial infections in a cohort from North India. A review of clinical and laboratory records was carried out for patients with CGD registered at our center between 1990 and 2021. Of the 99 patients with CGD, 22 had mycobacterial infections—Mycobacterium tuberculosis and M. bovis-BCG in 11 each. Among the children with M. bovis-BCG infection, 6 had localized and 5 had disseminated BCG disease. Median age at onset of symptoms and diagnosis of BCG disease was 5 months and 15 months, respectively. While disseminated forms of BCG were noted only in CYBB defect, none of the patients with NCF1 defect developed complications due to BCG vaccine. A recurring radiological feature was left axillary lymph node calcification, which was present in around 50% of CGD patients with BCG infections. Of 11 patients with tuberculosis, pulmonary, pleuro-pulmonary, abdominal, and disseminated forms were present in 6, 1, 2, and 2, respectively. Median age at onset of symptoms and diagnosis of tuberculosis was 129 months and 130 months, respectively. Molecular defects were identified in CYBB (5), NCF1 (4), and CYBA (1). Incidence of tuberculosis and BCG-related complications in patients with CGD is higher than the normal population. Screening for CGD is warranted in any patient with adverse reactions to BCG vaccination, calcification of left axillary lymph node, and persistent, recurrent or disseminated forms of tuberculosis. [ABSTRACT FROM AUTHOR]

Operation Greens Programme of the Government of India focuses on post-harvest management of Tomato, Onion, and Potato (TOP) crops, value chain development, and value realization of farmers' produce, which helps in enhancing livelihood security. The study conducted during 2022-2023 focused on factors determining the value realization of TOP crops under operation greens. The data were collected using a semi-structured interview schedule, with 90 farmers for each crop i.e., Tomato, Onion, and Potato. The government policy initiatives under Operation Greens were the most important factor, which mutually affected the socio-psychological, market intelligence, and input supply for TOP cultivation. About 42 per cent of respondents perceived Government policy under operation greens as important for value realization and 37.40 per cent of respondents perceived support from grassroots level extension agencies as important. Improving government policies followed for Operation Greens would result in the overall betterment of farmers and the agricultural sector of India. [ABSTRACT FROM AUTHOR]

Day-to-day clinical management of patients with inborn errors of immunity, including chronic granulomatous disease (CGD), has been affected by the coronavirus disease-2019 (COVID-19) pandemic. There is a dearth of information on impact of this pandemic on clinical care of children with CGD and psychological profile of the caretakers. Among the 101 patients with CGD followed up in our center, 5 children developed infection/complications associated with COVID-19. Four of these children had a mild clinical course, while 1 child developed features of multisystem inflammatory syndrome in children (MISC) requiring intravenous glucocorticoids. Parents and caretakers of CGD patients (n = 21) and 21 healthy adults with similar ages and genders were also evaluated on the following scales and questionnaires: COVID-19 Fear Scale (FCV 19S), Impact of Event Scale (IES-R), Depression, Anxiety, and Stress Scale (DASS 21), Preventive COVID-19 Behavior Scale (PCV 19BS), and a "COVID-19 Psychological wellbeing questionnaire." Median age of the parents/caregivers was 41.76 years (range: 28–60 years). Male:female ratio was 2:1. In the study group, 71.4% had higher IES scores compared to 14.3% in controls. The caregivers had a high prevalence of stress, anxiety, avoidance behavior, and depression compared to controls (p < 0.001). Children with CGD have had predominantly mild infection with COVID-19; however, caregivers/parents of these children were at risk of developing psychological distress. The COVID-19 pandemic has brought to light the importance of patients' and caretakers' mental health which needs periodic assessment and appropriate interventions. [ABSTRACT FROM AUTHOR]

Background and Aims: A rapid surge in rhino-orbito-cerebral mucormycosis (ROCM) cases was reported during the second wave of COVID, especially in India, needing extensive surgical debridement along with medical management. The present study was planned to observe perioperative anesthesia challenges and outcomes of patients with ROCM during the second wave of the COVID-19 pandemic. The primary objective was to observe intraoperative anesthesia challenges and the secondary objectives were to observe postoperative challenges and outcomes of patients. Material and Methods: This was a single-centered, bidirectional (retrospective and prospective) observational study, conducted at a tertiary care center. We enrolled 218 adult patients scheduled for surgical debridement of ROCM under general anesthesia. Demographics, COVID status, comorbid illness, intraoperative challenges (difficult airway, hemodynamic instability, blood loss), and postoperative outcome (postoperative mechanical ventilation, and mortality rate) were noted. Results: The majority of the patients were males (71%) and had diabetes mellitus (54%). COVID-associated mucormycosis was seen in 67% and 41% of them received steroids. Post-induction hypotension was noted in 20.6% of patients, and 14.2% had intraoperative hypotension out of which 5.5% required vasopressor support. Difficult mask ventilation and difficult intubation were reported in 7.3% and 6.4% of patients, respectively. No significant difference was found among intraoperative challenges when COVID mucormycosis was compared to non-COVID mucormycosis. Postoperative mechanical ventilation and ICU care were required in 41.3%, whereas mortality was seen in 11.5% of patients. The mortality was significantly more (P = 0.041) in patients with COVID mucormycosis (13%) compared to that with non-COVID mucormycosis (4.2%). Cbonclusion: Diabetic male patients who received steroids during COVID illness are at the highest risk of developing ROCM. Difficult airway and hemodynamic instability, are significant perioperative challenges encountered by anesthesiologists. Postoperative ICU management is crucial for decreasing postoperative morbidity and mortality. [ABSTRACT FROM AUTHOR]