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Your search keyword '"Wilsgaard, Tom"' showing total 2 results
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2 results on '"Wilsgaard, Tom"'

1. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Author

Gudbjartsson, Daniel F., Holm, Hilma, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Walters, G. Bragi, Thorgeirsson, Gudmundur, Gulcher, Jeffrey, Mathiesen, Ellisiv B., Njølstad, Inger, Nyrnes, Audhild, Wilsgaard, Tom, Hald, Erin M., Hveem, Kristian, Stoltenberg, Camilla, Kucera, Gayle, Stubblefield, Tanya, Carter, Shannon, Roden, Dan, Ng, Maggie C. Y., and Baum, Larry

Subjects
ATRIAL fibrillation, CEREBROVASCULAR disease, NUCLEOTIDE sequence, CHROMOSOMES, CLINICAL trials
Abstract

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 × 10−10). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples. [ABSTRACT FROM AUTHOR]

Published
2009
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2. Several common variants modulate heart rate, PR interval and QRS duration.

Author

Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, Stefansdottir H, Gudjonsson SA, Jonasdottir A, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Løchen ML, Kong A, Thorsteinsdottir U, and Stefansson K

Subjects
Aged, Arrhythmias, Cardiac complications, Arrhythmias, Cardiac genetics, Arrhythmias, Cardiac physiopathology, Atrial Fibrillation complications, Atrial Fibrillation genetics, Atrial Fibrillation physiopathology, Atrioventricular Block complications, Atrioventricular Block genetics, Atrioventricular Block physiopathology, Cardiac Myosins genetics, Female, Genetic Loci genetics, Genome-Wide Association Study, Humans, Iceland, Inheritance Patterns genetics, Male, Middle Aged, Myosin Heavy Chains genetics, Pacemaker, Artificial, Reproducibility of Results, Sick Sinus Syndrome complications, Sick Sinus Syndrome genetics, Sick Sinus Syndrome physiopathology, Electrocardiography, Genetic Variation, Heart Conduction System physiology, Heart Rate genetics
Abstract

Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21). We tested for association between these loci and subjects with selected arrhythmias in Icelandic and Norwegian case-control sample sets. We observed correlations between TBX5 and CAV1 and atrial fibrillation (P = 4.0 x 10(-5) and P = 0.00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval.

Published
2010
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