1. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
- Author
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Olafsdóttir BR, Rye DB, Scammell TE, Matheson JK, Stefánsson K, and Gulcher JR
- Subjects
- Adult, Chromosome Mapping, Cross-Cultural Comparison, Exons, Female, Genetic Predisposition to Disease genetics, Genetic Testing, Genotype, Humans, Iceland, Introns, Male, Middle Aged, Narcolepsy diagnosis, Orexin Receptors, Orexins, Receptors, G-Protein-Coupled, Receptors, Neuropeptide genetics, United States, Carrier Proteins genetics, Intracellular Signaling Peptides and Proteins, Narcolepsy genetics, Neuropeptides genetics, Polymorphism, Genetic, Protein Precursors genetics
- Abstract
The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
- Published
- 2001
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