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We simulated the COVID-19 Omicron spread in Hong Kong, China, by building a novel three-dimensional agent-based model that incorporates its vertically expanded, hyperdense urban environment. The model examined the effectiveness of the 'zero-COVID' interventions (i.e., Compulsory Universal Testing (CUT) and citywide lockdown) that were for debate during the Omicron wave in Hong Kong. We found that such stringent interventions would be effective only with even faster and stricter implementation. Therefore, flexible long-term strategies should also be considered to contain and prevent future infectious diseases., Competing Interests: Conflicts of Interest The authors have no competing interest to declare., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)