1. Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience.
- Author
-
Lo CK, Yu CH, Ma CC, Ko KM, and Leung SC
- Subjects
- Adult, Aged, Brain Neoplasms diagnosis, Brain Neoplasms secondary, Diagnostic Imaging, Female, Hong Kong, Humans, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Lymphatic Metastasis, Male, Middle Aged, Neoplasms, Multiple Primary pathology, Retrospective Studies, Small Cell Lung Carcinoma diagnosis, Small Cell Lung Carcinoma pathology, Survival Rate, Treatment Outcome, Brain Neoplasms surgery, Lung Neoplasms surgery, Neoplasms, Multiple Primary surgery, Small Cell Lung Carcinoma surgery
- Abstract
Objective: To report the surgical experience in the management of patients with synchronous primary lung cancer and solitary brain metastasis., Design: Retrospective cohort study., Setting: Regional hospital, Hong Kong., Patients: Seventeen patients with synchronous primary lung cancer and solitary brain metastasis were treated by pulmonary resection and neurosurgical intervention between 1994 and 2007., Results: Median patient survival was 52 months (95% confidence interval, 9-95 months) and the 5-year survival was 27%. The univariate analysis yielded no significant prognostic factor. Four out of six patients who had lymph node metastases developed tumour recurrence., Conclusion: In view of encouraging survival results, aggressive therapy including pulmonary resection and neurosurgical intervention should be recommended for patients with synchronous presentation with primary lung cancer and solitary brain metastasis.
- Published
- 2010