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Despite considerable advances in developing new and more sophisticated impact evaluation methodologies and toolkits, policy research continues to suffer from persistent challenges in achieving the evaluation trifecta: identifying effects, isolating mechanisms, and influencing policy. For example, evaluation studies are routinely hampered by problems of establishing valid counterfactuals due to endogeneity and selection effects with respect to policy reform. Additionally, robust evaluation studies often must contend with heterogeneity in treatment, staggered timing, and variation in uptake. And finally, on practical grounds, researchers frequently struggle to involve policymakers and practitioners throughout the research process in order to engender the type of trust needed for policy influence. While it can be difficult to generalize about appropriate evaluation methodologies across contexts, prominent policy interventions like governance reforms for improving health services delivery nonetheless demand rigorous and comprehensive evaluation strategies that can produce valid results and engage policymakers. Drawing on illustrations from our research on health sector decentralization in Honduras, in this paper we present a quasi-experimental, multi-method, and participatory approach that addresses these persistent challenges to policy evaluation. [ABSTRACT FROM AUTHOR]