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Emerging evidence suggests residential surrounding green space is beneficial for human health. The association between green space and GDM showed inconsistent results, and potential effect modification of green space with air pollution is still unclear. This study aims to evaluate the association between green space and GDM, and further explore potential interaction and medication effects. Participants were recruited from a retrospective cohort study between 2015 and 2020 in Henan, China. Residential green space based on normalized difference vegetation index (NDVI) and air pollution exposure were estimated using spatial-statistical models. Multivariate logistic regression was applied to evaluate the association between per 0.1 unit increase in NDVI with 4 buffer sizes (250 m, 500 m, 1000 m, 2000 m) and GDM. We examined potential interaction of green space and air pollutants on GDM. Mediating effects of air pollution associated with green space exposure on GDM were also investigated by causal mediation analyses. A total of 46,665 eligible pregnant women were identified. There were 4092 (8.8 %) women diagnosed with GDM according to the IADPSG criteria. We found that per 0.1-unit increment in NDVI 250 m , NDVI 500 m , NDVI 1000 m and NDVI 2000 m in second trimester were associated with the decreased risk of GDM, with adjusted OR of 0.921(95 %CI: 0.890–0.953), 0.922 (95 %CI: 0.891–0.953), 0.921 (95 %CI: 0.892–0.952) and 0.921 (95 %CI: 0.892–0.951), respectively. We identified significant interactions between second trimester PM 2.5 and O 3 exposure and NDVI for GDM (P interaction < 0.001). The causal mediation analysis showed that PM 2.5 mediated approximately 2.5–5.5 % of the association between green space and GDM, while the estimated mediating effect of O 3 was approximately 30.1–38.5 %. In conclusion, our study indicates that residential green space was associated with a reduced risk of GDM, particularly second trimester. Green space may benefit to GDM partly mediated by a reduction in PM 2.5 and O 3. [Display omitted] • The association of residential green space with the risk of GDM were explored. • We found second trimester green space were associated with a reduced risk GDM. • Green space may benefit to GDM partly mediated by a reduction in PM 2.5 and O 3. [ABSTRACT FROM AUTHOR]