1. Association of Dietary Fatty Acid Intake with Serum Highdensity Lipoprotein Particle Concentration.
- Author
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Zaid, Maryam, Katsuyuki Miura, Akira Fujiyoshi, Akira Okayama, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saito, Nagako Okuda, Katsushi Yoshita, Choudhury, Sohel, Rodriguez, Beatriz, Masaki, Kamal, Willcox, Bradley, Naoko Miyagawa, Stamler, Jeremiah, and Hirotsugu Ueshima
- Subjects
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FATTY acids , *OMEGA-6 fatty acids , *LIPOPROTEINS , *NUCLEAR magnetic resonance , *REGRESSION analysis - Abstract
Background: Studies have found that HDL particle (HDL-P) concentration is inversely associated with risk of CVD, independent of HDL cholesterol (HDL-C). Dietary factors (such as fatty acid intake) have been found to affect levels of HDL-C and influence risk of CVD. However, little is known about the associations of dietary fatty acid with serum HDL-P levels. Hypothesis: We hypothesized that dietary fatty acid associations with HDL-P are independent of HDL-C in men. Methods: Data were from 463 male participants in the 1996-98 cross-sectional INTERLIPID Study, ages 40-59 years, randomly selected from five populations; four in Japan (n=386) and one in Hawaii (n=77). Fatty acid intake was estimated from the mean of four in-depth 24-hour dietary recalls (% kcal per day). Individuals were excluded due to missing data on HDL-P or HDL-C and use of lipid lowering medication. Serum HDL-P was measured using nuclear magnetic resonance and HDL-C was measured using standard methods. Multiple linear regression models were used to assess the association between dietary fatty acid and each of the lipid measures. Results: In men, HDL-P and HDL-C were moderately correlated (r = 0.52, p<0.001). In Model 1 (Table), adjusted for age, country, alcohol intake, BMI, diabetes, hypertension, smoking status, and physical activity, most dietary fatty acids were significantly (p<0.05) associated with HDL-P and HDL-C levels. In Model 2, further adjusted for HDL-C, almost all fatty acids maintained a significant association with HDL-P. In contrast, most associations of fatty acids and HDL-C ceased to be significant after adjustment for HDL-P. Total SFA and omega-3 PUFA remained associated with HDL-C. Conclusion: HDL-P was significantly associated with fatty acid intake, independent of HDL-C. Associations of dietary fatty acid intake and HDL-C level were weaker and generally not independent of HDL-P in men. [ABSTRACT FROM AUTHOR]
- Published
- 2014