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Plants and herbal substances have an important place in veterinary phytotherapy and ethnoveterinary medicine applications. Some bioactive chemical compounds synthesized by plants have medical effects. However, the use of these plants and herbal materials can cause poisoning due to wrong identification, difficulty in adjusting its dosage, insufficiency of written records and scientific studies on their traditional use, poor hygienic conditions in preparation and variation in their chemical composition according to the region, where and the season when they are gathered, their used part, and their extraction method. In our study, it was aimed to determine the chemical compositions and to toxicologically evaluate the major compounds of T. spicata var. spicata L., Rosmarinus officinalis L., and Laurus nobilis L. grown in Hatay region and used in veterinary phytotherapy and ethnoveterinary medicine. Chemical compositions of plants contents obtained by solvent extraction method were determined by gas chromatography mass spectrophotometry (GC-MS) analysis. The major components of R. officinalis L. and L. nobilis L. were determined as 1,8-cineol (eucalyptol), in rates of 38.91%, and 33.70% respectively. The major component of T. spicata var. spicata L. was determined as carvacrol (48.82%). While these components have antimicrobial, anti-inflammatory and antioxidant effects, it has also been reported to cause undesirable and toxic effects such as organs damages (liver, kidney, pancreas and testes etc.), DNA thread breaks and respiratory problems. For this reason, it is thought that knowing the major components and their ratios of medicinal plants and materials used in animal health is important in terms of preventing potential toxic effects. [ABSTRACT FROM AUTHOR]