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Background: Numerous studies have shown that vitamins reduce the risk of cancers, but the relationship between serum vitamin levels of vitamin D and B12 in breast cancer is still controversial. In this study, we evaluated serum levels of vitamin D and B12 in Haryana, India among patients with carcinoma breast and investigated their association with clinical and laboratory parameters. Aims and Objectives: The study aimed to estimate and correlate the serum vitamin D and vitamin B-12 levels in patient with diagnosed carcinoma breast and in control subjects. Materials and Method: The present study comprises 60 subjects of both pre and post menopause women whom 30 are healthy controls and 30 are clinically confirmed cases of Breast Cancer, with an age group ranging from 38 to 70 years. Serum Vitamin D and B12 were estimated by ELISA Method. Results: The levels of vitamin D in serum was significantly (P > 0.05) low in clinically diagnosed breast Cancer patients (9.96 ± 2.45ng/dl) as compared to age and gender-matched healthy control subjects (24.54 ± 6.22ng/dl) and Serum vitamin B12 was significantly (P > 0.05) high in clinically diagnosed breast Cancer patients (1163.83 ± 135.77ng/dl) as compared to healthy control subjects (645.43 ± 134.22ng/dl). Conclusion: Many studies have shown that vitamin deficiency can be the primary cause of breast cancer. The current cogitation proved that raised serum Vitamin D and B12 are linked with the pathogenesis of autoimmune abnormal masses in Breast. It seems that Vitamin B12 level was no significant High and vitamin D levels are significantly low in the cases of Breast cancer. [ABSTRACT FROM AUTHOR]