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Reasonable building height distribution in urban residential areas is conducive to smoother vertical airflow exchange and promotes sustainable development. This paper studies the influence of building layouts on vertical ventilation in high-rise residential areas in Harbin, China, and discusses typical building layout objectives. The ideal area of 220 × 220 m was determined using statistical analysis and specification requirements, and seven typical layouts were defined based on the distribution of building heights. The computation fluid dynamics (CFD) simulation was verified using wind tunnel testing to improve the accuracy of the Phoenics simulation software. Wind speed, wind pressure, and the Universal Thermal Climate Index (UTCI) in residential areas distributed at different heights were analyzed and evaluated. The results indicated that the Phoenics simulation parameter settings, verified via wind tunnel testing, could achieve reasonable simulation results and different height distribution modes had an impact on the changes in wind speed and wind pressure. The equal-height layout that conformed to the row spacing of the buildings and the layout of taller buildings on the east side could provide higher comfort, and did not require enclosed and downwind layouts. This research can inform the green and livable design of residential buildings and provide a new perspective for the construction of high-rise residential areas in cold cities. [ABSTRACT FROM AUTHOR]