A recent study conducted by researchers at Zhejiang Chinese Medical University in Hangzhou, China, has identified a potential new drug target for antiviral therapy. The study focused on N-glycanase 1 (NGLY1), an enzyme involved in the degradation of misfolded glycoproteins. Through structure-based virtual analysis, the researchers screened 2960 natural compounds and identified three compounds, Poliumoside, Soyasaponin Bb, and Saikosaponin B2, that showed inhibitory activity against NGLY1. These compounds, found in traditional Chinese herbs, contain a disaccharide structure of glucose and rhamnose, which may bind to important active sites of NGLY1. The findings of this study could guide future drug development in the field of antiviral therapy. [Extracted from the article]