1. Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant-like action of riparin III obtained from Aniba riparia (Nees) Mez (Lauraceae) in mice.
- Author
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Melo CT, de Carvalho AM, Moura BA, Teixeira CP, Vasconcelos LF, Feitosa ML, de Oliveira GV, Barbosa-Filho JM, Chavez Gutierrez SJ, de França Fonteles MM, Vasconcelos SM, and de Sousa FC
- Subjects
- Administration, Oral, Adrenergic alpha-1 Receptor Agonists administration & dosage, Adrenergic alpha-1 Receptor Agonists therapeutic use, Adrenergic alpha-2 Receptor Agonists administration & dosage, Adrenergic alpha-2 Receptor Agonists therapeutic use, Animals, Antidepressive Agents administration & dosage, Behavior, Animal drug effects, Benzamides administration & dosage, Brain metabolism, Brazil, Depression metabolism, Dopamine Agonists administration & dosage, Dopamine Agonists therapeutic use, Ethnopharmacology, Fruit chemistry, Fruit growth & development, Guyana, Lauraceae chemistry, Lauraceae growth & development, Male, Mice, Neurons metabolism, Receptors, Dopamine D2 agonists, Receptors, Dopamine D2 metabolism, Serotonin Receptor Agonists administration & dosage, Serotonin Receptor Agonists therapeutic use, Tyramine administration & dosage, Tyramine therapeutic use, Antidepressive Agents therapeutic use, Benzamides therapeutic use, Brain drug effects, Depression drug therapy, Neurons drug effects, Tyramine analogs & derivatives
- Abstract
Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action of ripIII. Following intraperitoneal administration of ripIII at doses of 25 and 50 mg/kg, there were decreases in the immobility time in the FST and tail suspension test without accompanying changes in ambulation (data not shown). The pretreatment of mice with sulpiride (50 mg/kg, i.p.), prazosin (1 mg/kg, i.p.), yohimbine (1 mg/kg, i.p.), and p-chlorophenylalanine (PCPA, 100 mg/kg, i.p. for, four consecutive days) significantly prevented the anti-immobility effect of ripIII in the FST. On the other hand, the anti-immobility effect of ripIII (50 mg/kg, v.o.) was not altered by pretreatment of mice with SCH23390 (15 μg/kg, i.p.) Furthermore, ripIII potentiated the sleeping latency and sleeping time of the pentobarbital-induced sleeping time test and also potentiated apomorphine (16 mg/kg, i.p.)-induced hypothermia in mice. In conclusion, the present study provides evidence that the antidepressant-like effect of ripIII is dependent on its interaction with the serotonergic, noradrenergic (α₁- and α₂- receptors), and dopaminergic (dopamine D₂ receptors) systems., (© 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.)
- Published
- 2013
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